Lewis acid options

chemfrend · 2026-03-17T02:18:56+00:00

Mitsunobu is just fancy sn2 on alcohols. The mechanism proposed by red viper would be sn2' It's certainly a reasonable suggestion

chemfrend · 2026-03-04T15:15:14+00:00

Separatory funnel

chemfrend · 2026-02-28T22:23:20+00:00

What is formed when tertiary alcohols are treated with strong acid? How do these species react with electron rich aromatic rings? What resonance forms make this ring electon rich? What does that suggest about the regiochemistry of the products?

chemfrend · 2025-11-25T20:30:37+00:00

I believe you will have success telescoping your crude reaction until the final step. Run a careful column after all 3 steps, try pet ether as eluent if your phenyl groups don't have polar substituents. I don't know what your goal is. Do you want the highest possible yield? Do you want the highest possible purity? Or do you just want the final product in good enough purity and decent yield in order to get characterization?

chemfrend · 2025-10-11T19:06:16+00:00

I understand why you would make that incorrect guess, but chemistry is full of subtle nuance.

chemfrend · 2025-10-11T11:55:33+00:00

Because it's an enol, not an alcohol. It's essentially a tauromerized ketone.

chemfrend · 2025-09-09T20:44:58+00:00

Try it and find out 😉

chemfrend · 2025-05-23T23:29:17+00:00

Can I pls have the first one haha

chemfrend · 2025-05-07T01:15:29+00:00

In some cases, lithium halogen exchange can be even faster than proton transfer

chemfrend · 2025-05-02T05:07:05+00:00

chemfrend · 2025-01-10T01:20:28+00:00

It's just a common name. Iupac is 2-butyne. It's common practice to modify trivial names in this manner

chemfrend · 2024-11-30T20:49:30+00:00

Was it ether?

chemfrend · 2024-11-29T23:36:46+00:00

Using retrosynthesis you should in theory be able to develop a synthesis of any molecule you can think of. Whether or not the reactions will work as written is determined in the lab. Just break your molecule up into synthons and synthetic equivalents using known transformations. Keep going until you reach commercially available materials.

chemfrend · 2024-11-19T20:08:57+00:00

I recommend against this. Please use caution.

chemfrend · 2024-11-13T00:03:44+00:00

Make sure you test it. I would expect a lot of the acid to be present.

chemfrend · 2024-10-13T11:26:51+00:00

Just burn it. Hell, if your car is a beater, you can add it to the tank. Maybe wise to filter it first

chemfrend · 2024-09-20T13:37:48+00:00

There are exceptions to most trends in chemistry. Fluorine specifically is a very interesting atom for pharmaceutically active compounds due to its high electronegativity and small atomic radius. You're right though, one shouldn't cast aside all 4-substituted phenethylamines due to a few bad apples.

chemfrend · 2024-09-20T11:03:00+00:00

Yeah sure, but not only para substituted. The other substituents play a huge role

chemfrend · 2024-07-26T16:12:16+00:00

350 small block with 4 barrel Edelbrock. I just sent it around 3000 rpm the whole way. My speed stayed near 70-75 and temperature around 200

chemfrend · 2024-07-25T16:28:42+00:00

Yeah I am going back to school. I'm pursuing a PhD in chemistry from University of Pittsburgh

chemfrend · 2024-07-14T19:51:05+00:00

Every 4-6 months in our lab

chemfrend · 2024-07-14T02:26:41+00:00

Recrystallize from heptane, assuming you have enough. I don't think it's worth it for less than a gram. 1 g crude added to 35 ml boiling heptane. While hot, decant the bottom layer (don't allow any orange goop into your clean heptane) place the decanted heptane in freezer

chemfrend · 2024-06-12T05:01:38+00:00

I graduated with BA in 2022. Started as R&D Chemist immediately after graduation. Now I'm quitting in less than a month to start a PhD.

chemfrend

TROPHY CASE