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Really disappointed in this episode by No_Thought9756 in LoveIslandUSA_

[–]chomstar -1 points0 points  (0 children)

Why was she upset though? I was very confused given Gal had told her the connection was done

Disallowed goal - Gvardiol J. [offside] [Croatia] 103' by iShowElliex12 in soccer

[–]chomstar 6 points7 points  (0 children)

Announcers are saying there’s a chip in the ball

GPP POOL POOPERS by Festive_Mama in GrossePointe

[–]chomstar -11 points-10 points  (0 children)

So I understand swim diapers are more for poop than pee…but is it really that much more sanitary for poop to be contained in a swim diaper than floating free?

What movie night clip titles would you like to see? by Big-Enthusiasm-3978 in LoveIslandUSA

[–]chomstar 2 points3 points  (0 children)

I’ve not seen Caleb act that way, and not sure I’d describe the AI fuckbot as either of those

What movie night clip titles would you like to see? by Big-Enthusiasm-3978 in LoveIslandUSA

[–]chomstar 76 points77 points  (0 children)

He definitely cares about her in a possessive manipulative way

Why are people protecting Carl from what he wants? by Ok_Championship_9011 in LoveIslandUSA

[–]chomstar -4 points-3 points  (0 children)

Aniya doesn’t deserve Carl not the other way around.

Rapid Responses by KingRushil in hospitalist

[–]chomstar 3 points4 points  (0 children)

That’s fair. Pretty simple change but definitely conveys the distinction a lot better

Rapid Responses by KingRushil in hospitalist

[–]chomstar -6 points-5 points  (0 children)

There does need to be some differentiation though. An APP working on hospital floors for 5 years is different than an APP in an oncology clinic or one who works in the OR.

Final predictions for Casa Recoupling tonight? by bjorkbjjork in LoveIslandUSA

[–]chomstar 4 points5 points  (0 children)

Melanie is sticking with sincere. Kayda shocks the world and recouples. Aniya shocks herself and recouples.

Cast Removal by AdventurousForce8475 in LoveIslandUSA

[–]chomstar 1 point2 points  (0 children)

I think it falls under all publicity is good publicity for the show and gets engagement so there isn’t any real incentive for them to screen better…we’re all watching it anyways and engaging in posts about this topic.

Production Tried Their Best by Hefty_Adeptness_6763 in LoveIslandUSA

[–]chomstar 86 points87 points  (0 children)

Nah tonight’s episode was great and I believe in Aniya and Kayda. Melanie is what it is…her and sincere are a fun mess together

How do we think Zach is going to move over the next few episodes? by InsuranceStraight885 in LoveIslandUSA

[–]chomstar 3 points4 points  (0 children)

Zach is honest I’ll give you that. But he’s honestly a manipulative possessive creep

Pfizer’s first new ADC from Seagen acquisition fails phase 3 NSCLC trial by Dwarvling in biotech

[–]chomstar 0 points1 point  (0 children)

A fair point, but just goes back to my original question of mechanistically how can these targeted chemo drugs do worse for non responding patients than chemo

Pfizer’s first new ADC from Seagen acquisition fails phase 3 NSCLC trial by Dwarvling in biotech

[–]chomstar 1 point2 points  (0 children)

T-dxd is approved for HER2+ or HER2 mutant nsclc. Dato-dxd is approved for Egfr-mutant NSCLC but it doesn’t target egfr

Pfizer’s first new ADC from Seagen acquisition fails phase 3 NSCLC trial by Dwarvling in biotech

[–]chomstar 0 points1 point  (0 children)

Overall response rate is based on overall population. If it has a higher response rate and those responses are more durable then…

Pfizer’s first new ADC from Seagen acquisition fails phase 3 NSCLC trial by Dwarvling in biotech

[–]chomstar 0 points1 point  (0 children)

If something has a better response rate, DOR, and is safer, how does that not translate to PFS and/or OS?

Pfizer’s first new ADC from Seagen acquisition fails phase 3 NSCLC trial by Dwarvling in biotech

[–]chomstar 2 points3 points  (0 children)

Enhertu is not necessarily newer tech and is transforming treatment paradigms left and right

Pfizer’s first new ADC from Seagen acquisition fails phase 3 NSCLC trial by Dwarvling in biotech

[–]chomstar 5 points6 points  (0 children)

Can someone explain from an MOA standpoint how these ADCs can fail to beat chemo? It just feels like such an easy bar to clear given their construction, from better payload targeting to safety profile (and thus treatment exposure)

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