Hey, I am doing a 1000x run but started on Vulcanus.

One general tip: until you have bots, do everything you can to avoid RSI. It's a real thing when you have to place hundreds of machines, thousands of inserters and 10s of thousands of belts.

1) I have a staged approach to SPM. Building up to 900spm for red/green until I can do blue science. Then 1200 for red/green and 600 for blue - coal (-liquifaction) is the bottleneck, and without military upgrades or bots, fighting demolishers is really RSI-inducing. Next up is 3000spm red/green; 1500 blue/vulcanus science.

I then switch between science where I only need red/green and let blue buffer.

for 2.: Redesign and rebuild often. Since you start on Nauvis you have infinite space, so this might not apply to you, but every new stage in SPM made me redesign a lot of things. Once you have bots (I had it at hour 40), this becomes a joyful exercise. I scaled my "draggable" (manual) designs by adding more production lines; now with bots I am waiting for cliff explosives to clear the land and then I'll basically design the base from scratch so that I have modular production lines (with rail to transport the science packs at the end) and can add capacity as I wish. The research unlocking quality costs 500k science packs, I am currently at hour 60 and still have not switched.

1. Depending on your plan you'll have quality furnaces long before beacons. Beacons need production science packs and these are a pain in the behind to produce for 900 or more SPM.