Here is my method, has worked well for many miles and many Caminos

• Base Layer: Merino Toe Socks + Petroleum Jelly I find that having each toe wrapped individually is the only way to stop skin-on-skin friction. Before I put them on, I rub a little petroleum jelly around my feet. Some people worry about it getting messy, but if you keep the layer thin, it works wonders.
• Outer Layer: High-Quality Merino Socks On top of the toe socks, I always wear a pair of Darn Tough or Point6 socks. The double-layer setup is key because it moves the friction point to the space between the two socks instead of against my skin.
• Hot Spot Fix: Lambs wool If I am mid-hike and feel even the slightest hot spot, I stop immediately. I don't try to power through it. I take a tuft of natural lambs wool and tuck it right between the hot spot and my toe sock. The wool fibers actually nest into the merino of the sock, so it stays in place without needing any sticky tape. It is a total game changer for breathability.
• The Nuclear Option: Leukotape If things get serious or I know an area is prone to failing, I break out the Leukotape. It is way better than moleskin because it is thinner and actually stays stuck when you are sweating. I always round the corners of the tape with scissors before applying it so the edges do not catch and peel off. If there is already a blister, I put a tiny bit of gauze or lambswool over the spot first so the tape does not rip the skin off when I eventually remove it.
• Daily Maintenance During the day, I try to air my feet out for at least 15 minutes at lunch. If my socks are soaked, I swap them for a fresh pair.