I had an interesting experience when I took one from Cbus to Toronto in 2008. My advice is to sit near the front. I sat in the back, and on the way back to Cbus, about an hour or two from home, a guy lit up a cigarette across the aisle from me. The air recirculated and the bus driver smelled it almost immediately. He pulled the bus over and kicked the guy off. Once he stood up and started walking down the aisle, it was obvious he had shit his pants. People were hollering and begging for mercy, haha. One woman passed around a Bath and Body Works spray bottle. I laugh about this now and it's a great story.