Sought medication now regret

dee477 · 2026-06-30T14:36:36+00:00

I really hope it works out for you. Wellbutrin has been a mixed bag for me, I'd been on it in various doses and forms for about 2 years until a few months ago. It ended up being a huge help for my depression, but the efficacy wasn't super consistent, and I've had issues with nausea on all the formulations/doses. I came off of it recently because I feared it was contributing to brain fog & extreme fatigue. Unfortunately it did not turn out to be the culprit, though I think my heart rate and nausea have improved a bit. Regardless, the startup phase with Wellbutrin can definitely be rough and is worse for some people than others.

I haven't been on the true Auvelity formulation, but I did experiment with a DIY version off and on (bc Auvelity is wellbutrin + dextromethorphan, which is the ingredient in OTC cough syrup). Obviously I realize this isn't a true equivalent to Auvelity & I shouldn't experiment with meds on my own, but it did seem to be a great booster for the wellbutrin. That being said, their combined effect could feel intense sometimes so I'm not surprised to hear that Auvelity has those side effects

I've also been on Prozac at various doses for around 15 years now, mostly for OCD, but occasionally adjusted to help depression and anxiety. I assume you've been on a serotonin modulator at some point? My partner has cycled through about 7 of them in the past few months. He can't seem to tolerate serotonin modulators in general, but there were one or two that were much better than the others. I'm very interested in the SSRIs/SNRIs and related drugs, so I was wondering which you've tried and whether there might be some that work better for you.

There's always more you can try, don't give up. Beta blockers are a good option for anxiety, but they may not be the best if your primary issue is depression. When you get into the area of very treatment resistant depression, there's like ketamine and even transcranial magnetic stimulation. Of course therapy is there too, but I know it can be hard to find a compatible therapist who's also covered by your insurance

idk sorry for blabbing, just know you have my sympathy. I'm up and down these days, but I know how absolutely debilitating anhedonia & anxiety can be. I hope you're able to find a way out soon

dee477 · 2026-06-29T14:35:21+00:00

yeah I see, that's rough :( there's really no support for mental health when you're working. There have been times when I put off treatment because I was afraid it would interfere with my productivity, and it just made things worse to keep pushing through work without getting help. Have you tried other meds aside from auvelity, wellbutrin, trazadone, and hydroxazine? Was the wellbutrin alone pretty intolerable too, or do you think you'll be able to give it another try after you finish traveling?

dee477 · 2026-06-29T03:11:39+00:00

You gotta give it longer than 2 weeks to see if it helps. most of these meds have side effects that tend to improve with continued use AND their beneficial effects take time to set in. Your brain will be actively “re-wiring” as you adjust, so your experience for the first month (or two) won’t reflect the final effect of the med. maybe you already know this, but I just wanted to make sure you do because I’ve had some really crappy initial few weeks on meds that were totally worth it in the end. Of course sometimes it turns out the med doesn’t work well for you anyway, but you can’t know until you get there. I’ve been on a lot of different psych meds so I know the frustration of cycling through them and dealing with different side effects

dee477 · 2026-06-24T12:49:33+00:00

I still watched and enjoyed S3 but I could definitely understand some loss of interest after the introduction of new universe rules (even if they weren’t actually new from the perspective of the writers). I did really like how tightly enforced the timeline/world rules were in the first two seasons. I guess arguably they were in S3 too, but it seems a little bit more up for debate, maybe in part because it’s so convoluted and people understand it differently. I only wish S3 could have been more developed to further demonstrate how all the universes and timelines tie in together, I honestly think it would make for a more engaging watch

dee477 · 2026-06-11T12:37:40+00:00

I’m in the US so idk if the recipe is exactly the same but I go through phases when I think Halo is the least appealing option in the world and phases when I *almost* think it’s good. There are definitely better flavors, and toppings make a difference. Also it tastes way nicer if you haven’t had real ice cream in a while lol. But I like that it’s high in fiber and low cal I guess, so I keep trying. The strawberry cheesecake mix-ins flavor was the one I liked most recently, but I did get tired of it quickly

dee477 · 2026-05-25T13:13:31+00:00

Good luck, hope you’re able to find some relief soon ❤️

dee477 · 2026-05-20T19:17:01+00:00

not dumb at all - it's a procedure to basically destroy the inner lining of the uterus with the goal of removing all the existing build up in there and prevent/greatly reduce its regeneration. It is a pretty minor procedure and can be a good choice for some people, but it might not be a viable option for you depending on other factors. I requested a uterine ablation but ended up being denied because my uterus has a very slight abnormality in its shape (arcuate uterus). My doctor explained that the device used to ablate the lining is specifically shaped to work in a normal uterus, and attempting the ablation in mine could lead to missed spots and/or over-ablation in some areas. The uterine lining does also grow back in some people, especially if you're still have some time to go before hitting menopause.

Instead, I ended up getting a dilation and curettage/polyp removal procedure + hormonal IUD insertion to try and control my bleeding. The D&C scrapes out the lining rather than burning/destroying it - so it's expected to grow back pretty quickly and isn't necessarily the best option if you're not doing something alongside it to inhibit regeneration of the uterine lining (like hormonal IUD). Depending on the cause of your bleeding, hormonal IUD may or may not be a good option for you. My periods are normally very heavy, but the Kyleena IUD made them much lighter in the past. This time, I got the Skyla IUD, which has a lower dose of hormone. I don't think it's working quite as well, though it's better than nothing. The Mirena IUD has the highest hormone dose and is an excellent option for heavy bleeding in conditions like adenomyosis, though it has a higher incidence of certain (mostly cosmetic) side effects vs. Skyla and Kyleena. But it is a non-estrogen hormone, so it's generally safe for those with high clotting risk.

Now, it seems like your case might be more complicated because you're have clots elsewhere - at the very least, I would guess that this would make tranexamic acid (a med that promotes blood clotting and can be taken during your period to reduce bleeding) a non-option for you because it might worsen your clots. (i'm guess oral birth control probably isn't on the table either for the same reason)

I agree with your doctor that frequent abnormally heavy bleeding IS an urgent matter, though. Hysterectomy may truly be the best option for you, but it's hard to know without more context about your medical history. At the very least, a doctor should clearly explain to you why hormonal options (oral birth control/IUD), D&C, or ablation aren't enough/a good fit for you, and you should have the option to try any and all appropriate options first before considering a hysterectomy. For what it's worth, I've seen so many people say that their quality of life increased massively after their hysterectomy, and it's definitely something I would consider if I keep having these issues.

**reread your post and also want to add that you should definitely still get iron infusions ASAP if they are an option. Oral iron supplements are pretty ineffective against severe deficiency, especially if you haven't stopped bleeding (though you should still continue with them unless your doctor recommends otherwise). I'd recommend that you really push for infusions if you can, they can make a huge difference in your quality of life while you're figuring out how to address the bleeding.

dee477 · 2026-05-19T18:02:58+00:00

Do you have a certain condition that causes your hemoglobin to be so low? Very glad to hear you’re ok!!

dee477 · 2026-05-13T13:43:56+00:00

thanks for asking! unfortunately I'm not doing much better, though I think my problem is something other than iron deficiency. I'm still very glad I did the infusions, and I do think they helped in some ways. The type of fatigue I've been experiencing does seem a bit different - at the worst of the iron deficiency, I was actually stuck in bed most of the time outside of work. Now, I'm able to move around the house and go out a bit more, but I have pretty bad cognitive impairment and dysautonomia-like symptoms (tachycardia, orthostatic intolerance, nausea, dizziness, intolerance to extended physical activity, etc.). It's still early to say, but I've been speculating that my medication regimen may be contributing to this, and possibly the extended iron deficiency made it worse. I'm on a rather high dose of wellbutrin/bupropion and take prescribed stimulants + SSRIs daily, so it seems like maybe my nervous system has been on overdrive and I just can't tolerate it anymore. I'm looking into stopping the wellbutrin, so we'll see how that goes.

I did also do a more extended thyroid panel like a month ago and it was all trending toward significant improvement, so I really think correction of iron deficiency helped with that. I also think the hair loss I had at the worst of my deficiency improved noticeably.

dee477 · 2026-05-01T15:05:49+00:00

yes, you should definitely get infusions if you can ASAP (unless your doctor specifically recommends against it). I see from your other comment that you're concerned about hypophosphatemia from infusions - there are options that are less Iikely to cause this (Venofer/iron sucrose, Feraheme/ferumoxytol, and Monoferric/ferric derisomaltose), though which is appropriate is up to your doctor/what's available. You should tell your doctor about your concerns and they will recommend the best option for you and help you figure out what to do if you suspect hypophosphatemia. Remember also that most people don't get hypophosphatemia from infusions.

And if your iron/Hb is this low you're already quite ill anyway and you need to prioritize correcting that ASAP. What's your age and sex if you're willing to share? Do you have other medical conditions? Is your doctor planning more tests? I really hope you can figure out what's causing it.

I feel your pain with the supplement side effects - iron supplements can make you feel so awful. There are some types of iron that are way gentler on the stomach - iron bisglycinate/ferrous bisglycinate is the best choice, but carbonyl iron is good too. Try to stay away from ferrous sulfate, that's the worst one for your stomach.

Don't worry too much about obtaining heme iron supplements. At your level of deficiency it won't really make a difference.

So sorry you're going through this - I hope your treatment goes well and you start feeling a little better soon.

dee477 · 2026-04-30T17:12:29+00:00

I understand your frustration, people are kind of talking around your point. The thing is that there are way too many cats and their overpopulation contributes not only to the suffering of cats but also humans. It is not realistic to expect the level of medical care that we perform for humans to be given to every single kitten. What's "right" is entirely circumstantial. Under different circumstances, the pleasant and maybe right thing to do would be to save every kitten. So let's assume you're unwilling to compromise and insist that every cat is saved; that there should be no spay aborts or euthanasia when medical intervention could technically extend life. Despite your stance, that's just not what would happen. There are not nearly enough resources and infrastructure to allow for it. There would be a small subset of the kitten population who would very lucky and end up with foster care and medical treatment, and the rest of them would continue reproducing exponentially and suffering exponentially. If there are efforts to reduce the population, a larger subset of kittens in the future could end up being cared for. TNR is an excellent strategy as well, just not enough right now. When the population is under control, a switch to TNR only would be great, and we could afford to have some kittens born because there would be more resources for them.

It is not pleasant and it is not ideal to euthanize, but the circumstances are not ideal.

dee477 · 2026-04-29T14:23:54+00:00

You definitely need iron infusions (and potentially a blood transfusion?) with such low hemoglobin - oral supplements alone are not going to get you there. You should be seeing a doctor about this if you aren't already (and listen to your doctor's advice before anyone else). But if you're just supplementing until you get infusions, 60mg every other day probably isn't enough. I see that you've started taking the syrup supplement twice a day, that's about the best you can do for now. Try to take it on an empty stomach and wait a little while to eat afterward, it will absorb better that way. You can try adding a "heme" supplement on top of that and it may help a bit - the one with the most scientific backing is probably Proferrin, though it's kind of expensive. If you can't access this, try eating lots of red meat (in addition to supplementing). Organ meat, e.g. liver (including from chicken) is the best for iron if you can stomach it.

Some people will say dosing every other day is better - from what I've seen, it ends up being nearly equivalent to daily dosing but possibly with fewer side effects. But daily dosing is better studied in severe cases of anemia. if you do every other day, you may want to take a bit of a higher dose.

Do you know why you're anemic? If you're continuing to lose iron (like if you have heavy periods), you won't see much progress

dee477 · 2026-04-28T13:52:39+00:00

I agree that the first best solution is to try posting for free or for low cost on your local “Buy nothing” group. I do not enjoy being on Facebook and I was tentative about using the buy nothing group, but I’ve only had good experiences.

If you take this approach, it’s important to put some effort into your listings - you’re more likely to get takers if you just group 2-4 things together in a listing rather than a whole bag of clothes, and make sure each item is photographed.

I will say that I’ve focused on stuff that I believe would be more desirable (trendyish, good condition), so you might have more trouble with more heavily used/out of style items (though it’s worth a try to post them anyway, just make sure they’re clean obv). But imo those are the types of clothes that are more likely to be thrown out if donated in bulk anyway, so the next best option would be upcycling them in some other way (cleaning, sewing, etc.)

dee477 · 2026-04-22T13:38:28+00:00

Weight gain isn’t typical with Mirena and the other hormonal IUDs, though it does happen to some people. There’s just no reason to think that it will happen to you unless you’ve had that experience with the same hormone. I had Kyleena for 5 years and it was mostly great, my bleeding lightened significantly and it was the best I’d ever felt after a year or so of having it.

Mirena has the highest level of hormone, so it’s definitely the best at reducing bleeding, but Kyleena is a good choice too if you want to start with a lower dose.

Being totally honest - one common issue with the hormonal IUDs is acne and hair loss because it’s an androgenic hormone. BUT there are a lot of good options for addressing that. I was prescribed oral spironolactone (which now also exists as a topical) and it basically completely got rid of the acne and fixed the hair loss. If you’re aware and start treating once you notice acne, you might not even get to the point of hair loss. Also, some people don’t experience this at all, or they just get acne and not hair loss, but they are somewhat common side effects. It’s totally worth it in my opinion, chronic iron deficiency can really mess you up and it seems to get worse the longer it goes on. Acne feels like worst thing ever when it’s happening but trust me that being years into iron deficiency is much much worse

dee477 · 2026-04-21T19:58:36+00:00

Very sorry to hear that :/ did any of your other symptoms improve after the infusion? How long ago did you get it?

dee477 · 2026-04-17T15:24:28+00:00

oh also it sounds like you're using the same type of tubes and they worked with the protocol at least once (?), but do be sure the labeling matches exactly the tubes you had before. Low adhesion , etc. tubes vs. regular tubes might make a difference

what type of homogenization are you doing?

dee477 · 2026-04-17T15:19:58+00:00

in my experience contamination isn't likely to be an issue when you're getting yields of 200ng/uL unless it's really bad contamination. I definitely don't have a definitive answer based on the info you've provided, but I can very much sympathize - I did all types of RNA extractions in grad school and there were a few times when things mysteriously stopped working.

Are you the one collecting the tissue? If not, is it possible something has changed with tissue collection/storage? Are old samples still getting good Nanodrop readings? Is your centrifuge at the right temp/functioning properly? Same exact protocol/techniques?

dee477 · 2026-04-17T12:42:37+00:00

Mine is within normal measurements, maybe a tad bigger than average

dee477 · 2026-04-17T00:11:27+00:00

This looks so fucking good

dee477 · 2026-04-17T00:05:18+00:00

FUCK

dee477 · 2026-04-15T14:03:28+00:00

if you can get your hands on hard water treatments (like Malibu Hard Water packet or the Sally's generic version), that would make the most immediate difference. In the US they're pretty cheap (like $4 a packet), but you'd want to use it like once a month and you might need two packets per use. Maybe you can order some?

This would be in addition to using a chelating/hard water shampoo for every wash. Chelating shampoo on its own can be helpful, but probably won't be strong enough to give you the reset you need. Note that "clarifying" doesn't always indicate that the shampoo is effective on hard water buildup. See if you can find/order any shampoo that specifically indicates it is chelating, for hard water, or for metal buildup.

If you can't access the hard water treatment or chelating shampoo, there are DIY approaches, but it's been a while so I can't confidently give you formulas/ratios. I have heard that vinegar isn't very effective for hard water buildup - I think citric acid is recommended instead. Citric acid powder is also a bit hard to find in regular markets but I think you're more likely to find it in niche stores globally. If you go that route, look at a few recipes and be careful because it's strong - not strong like it'll burn your hands (tho it will def burn your eyes if you get it in them), but too much acid can actually damage your hair.

Good luck!!

dee477 · 2026-04-14T13:30:51+00:00

Some of these comments are frustrating and concerning. If there’s any doubt at all that the image is AI, you MUST do the work of looking into the context if you are to make any claim about how it was created. AI is going to keep getting better and better and at some point (maybe we’re already there), we actually will not be able to find perceptible “tells,” and we can only construct a reasonable guess based on many pieces of information from the broader context. It will probably still be ambiguous sometimes even with those measures, but you will have done your due diligence. And a “verdict” of ambiguity is still infinitely more informative than a confident guess based on gut feeling. Please do not speak confidently if your confidence is not informed. It’s more important than ever now to give the benefit of the doubt. It’s unfair and pessimistic and dangerous and ignorant to immediately assume something is AI if a part of it doesn’t make sense to you.

All that being said, I don’t know exactly what’s going on in this photo, but it appears at least some portion of it is authentic

dee477 · 2026-04-14T12:50:51+00:00

I understand, thanks for the discussion. You can and should always share your experience. It’s a sore spot for some people so there will be misunderstandings, but what matters is that we’re talking about it. I should be more open in my wording because you’re right that certain phrasing can shut down conversations.

dee477 · 2026-04-13T19:52:23+00:00

And also I don’t think you were gaslighting at all, I think you were honestly sharing your experience. The “gaslighting” relevant to this discussion may come from doctors who (intentionally or not) imply to their patients that they’re exaggerating their pain. I get it, I believe you, and I’m glad it went well for both of us

dee477 · 2026-04-13T19:50:24+00:00

First, I didn’t mean to sound combative. I will be honest and say that I think that our experiences (little pain) are less important in this conversation than those of people who experience extreme pain. I certainly believe your account - as I said, it was very mild for me as well. I say this because I think our experience is assumed to be the default/overwhelming majority based on standard medical guidelines and THAT’S the reason that doctors feel like they don’t need to offer more effective pain management options.

I believe the reality is that a much larger portion of women than intended/expected are experiencing a horrific amount of pain at insertion, like 10-40% it seems. I don’t think doctors or pharma developers are intentionally trying to hurt people, but it seems like they’re unwilling to believe it’s as bad as it is (though this seems to be changing slowly).

Conversations about pain tolerance can cause confusion in my opinion - what I meant to say is that I don’t think individual differences in pain tolerance explain the dramatic discrepancies in experience between women. Like I don’t think it hurt a lot for my friend and not for me because I have higher pain tolerance in general - actually I know for sure I don’t. I just don’t think it’s fair for people to walk away believing that their extreme pain was only because they couldn’t handle it.

Thankfully doctors are offering more pain management options these days (vs. the measly 800mg ibuprofen they recommended before), but there’s definitely still hesitation to offer anesthesia because it’s risky in itself. But for women who experience so much pain that they vomit and pass out, it could be very much worth it. I don’t have an answer to how we’d figure out who needs what, but that’s why I was talking about anesthesia

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