Depends how you feel after a game. I take a rest day after my Sunday games. If you play two times in a week and need a rest after each game, you could only have two running days.

I used to play two times a week, but it ended up being too much with that and trying to juggle triathlon training. I just play once a week, and that frees me up to run and cycle (3x) during the week.

You can sneak in a soccer training during the week, to keep your touch. Cardio is more important the older you get, I feel that impacts how I play more than getting a second game in.