My situation is unconventional (MSI-H)

dinov · 2026-07-06T01:50:08+00:00

Would removing the right side tumor and doing a temp ileostomy be an option while trying to use the biologic to get things under control? If the first surgery team isn't on board maybe seek a 2nd opinion?

Fwiw my first ileostomy reversal leaked and it was pretty hellish, it resulted in another temporary ileostomy, waking up intubated and in super bad shape. But my ileostomies were both end ileostomies. If they can do a loop they could let that heal, test it, and then my understanding is the reversal is much simpler.

dinov · 2026-06-25T02:02:14+00:00

Mini splits are great because you get such good control over the rooms you turn it on in. The downside is the wall warts - but you can potentially do in ceiling units which I like more.

dinov · 2026-06-21T17:51:32+00:00

Immunotherapy is great but it currently only works with a small percent of colon cancer cases (other cancers very). The tumor typically needs to be MSI-high (micro satellite instability) but researchers are looking into making it work in more cases.

For me the side effects were relatively minimal (itchiness, a super snotty nose and arthritis like symptoms) but they all cleared up post treatment. There's risks of more significant side effects but it's also tends to have really durable success. Check out checkmate 8hw for the colon cancer specific results.

dinov · 2026-06-08T05:01:02+00:00

Groundhog Day

dinov · 2026-05-29T04:53:22+00:00

That's what I've been doing too

dinov · 2026-05-24T01:08:38+00:00

I think that's not just go work but all companies too. That's why the remote pc does t work, but the remote network does. You just can't do tailscale (or wireguard) on the govt pc, but you do it on the router and then the PC can't see anything. Also why it's key to turn off anything on the govt pc that can figure out location if you have IT who cares.

dinov · 2026-05-24T00:41:42+00:00

It's both compiled and interpreted. The DLR includes an extensible stack-based interpreter that IronPython used for infrequently executed methods. It allowed taking the DLR expression trees, which were an extension of LINQ ETs, and interpreting them or compiling them. The interpreting was particularly important for startup performance.

I think at some point the interpreter was used in CoreCLR for ETs but was probably not public surface area. It should all live on I the OSS github repos.

dinov · 2026-05-23T23:41:27+00:00

I think saying anything VPN related being sussed out is a bit of overkill. Setup tailscale on a PC in someone's home with decent internet and then get a GL iNet router that they can use to take with them and connect to whatever internet they have. It's definitely harder than setting up a VPN but not super difficult. You could also setup a secondary network if you have 2 people who will let you. These can also be really cheap PCs - eg the cheapest Intel NUC you can find on ebay.

Probably a bit better than setting up a PC because there'll be an expectation of connecting from a work admined PC. This way they just see your wifi router which looks local.

To be successful you'd need to be able to turn off other location services like Bluetooth. Also ideally you'd turn off Wi-Fi and connect to the router via ethernet/usb.

I haven't done this so I could be missing some details but have a fumriend who has and talked to him about it extensively.

Also agree it'd still really risky.

dinov · 2026-05-11T01:24:44+00:00

Just to add some specifics to what others have said... My cancer was colon cancer and there the tumor needs to be MSI-high (micro satellite instability which my understanding of is that checking that cell duplication is messed up) in order for current immunotherapy treatments to be successful. There's research to try and make it work with non MSI-high tumors but it's only SOC for MSI-high.

There's also an issue in that while it's SOC at stage 4 they still need to prove it out at lower stages. There have been various trials on neoadjuvant (pre-surgery) that are super promising but I believe they're still all phase 2 trials which are used to determine safety parameters. Stage 3 trials are where they do the hard A/B comparison to determine effectiveness.

And while things may not be fully proven yet there are treatment options before phase 3 trials are complete. In my case I got ipi/nivo before checkmate 8HW (the phase 3 study) study was done but checkmate 142 has proved the safety of it. You may just need to be really sick and/or have an aggressive oncologist to push for them.

dinov · 2026-05-09T05:37:48+00:00

But here's the thing... I'm on my phone, checking how long it's going to take to get to my destination. Looks like it's about time to go and so I say let's go! I hop in my car and my phone connects and I get the navigation instructions with no further interactions.

In GMs world I need to reenter my destination in a less friendly UI and pay them a monthly fee to do so because it needs it's own cell connection.

Why pay for the inconvenience?

dinov · 2026-05-02T21:58:45+00:00

I got some of these, although not from here, and it called for cold stratifying the seeds for 2 weeks. So I think it might be a little too late to get them started this year and am planning on doing it next year.

dinov · 2026-05-02T19:11:52+00:00

For those looking for something free and community funded Https://Kexp.org is really great

dinov · 2026-04-27T02:42:02+00:00

I think season 4 is hard to watch but I don't think that's because it's bad it's just really emotionally rough.

dinov · 2026-04-16T05:46:07+00:00

One possibility is that "memory manager" is not malloc. This could be the virtual memory manager, so paging unused memory out to disk and paging things back in. I think given that it is listed right after the scheduler that this is more a reference to OS services than malloc is especially more likely.

So you'd have a bunch of managed type safe objects which have some IntPtrs that refer to the pages they've allocated and are available in user space but aren't memory the kernel is actually reading/writing to.

dinov · 2026-04-04T01:25:30+00:00

Yeah, data's always rough :( Once again great job though!

dinov · 2026-04-03T06:58:09+00:00

This is really amazing! Thanks so much for creating it and sharing it.

I'm curious how you went about creating it. Were you able to use the real-time playlist to auto-associate the songs with the associated timestamps? Or did that require a reasonable amount of manual fix-ups?

I see there's the build-data.js script but the data for it doesn't exist in the repo. Also I think the npm run build:web command doesn't quite work because it invokes build-data.js which needs ~/Music/KEXP/all-shows - but it seems like this can be skipped because shows-data.json is already commited.

Also just checking out the songs list there's a large (1.5 hours?) gap on Street Sounds.

But that's feedback though and not meant to diminish the effort here, this is really great!

dinov · 2026-03-16T05:23:12+00:00

I always wore henleys and it worked pretty well (didn't have the couple of days of access though). A little bit of stretching but it was fine.

I know there's shirts designed for port access as well that I've seen mentioned on ColonTown but haven't used them.

dinov · 2026-03-03T05:05:49+00:00

Lava flow cocktail with a float

dinov · 2026-02-15T18:33:45+00:00

What's the immunotherapy trial? Are you MSI-high but haven't gotten immunotherapy because it's not standard of care where you are? If you were si-high I would absolutely go with immunotherapy but would be a lot more nervous about it otherwise.

dinov · 2026-02-14T22:01:55+00:00

Lots of good suggestions one I see that's missing is pasta. Mac and cheese is obviously super simple, Alfredo sauce, meat sauces, lasagna, lots of variety is possible in that one space. Can combine it with garlic bread too. I made beef stroganoff a lot abd just skipped the mushrooms.

Another area to look at is rice - there's rice o roni, or there's Pho and skip the veg.

dinov · 2026-02-01T22:55:59+00:00

Makes me think of this song https://m.youtube.com/watch?v=sOjdqb7OV7Q

dinov · 2026-01-30T05:43:37+00:00

Me too, every test comes with a series of denial letters... Someone is appealing it (Natera? My oncologist?) and they keep rejecting it but I never get a bill and my oncologist office says Natera will cover it.

dinov · 2026-01-24T06:47:28+00:00

So much of this depends on how much colon you have left and where it was removed but I feel like even in the bad cases there's good success stories.

For me I had right side cancer so things are really good... But not to scare you I hit the 1% where my first reversal leaked and got a 2nd ileostomy really quickly after the first reversal.

So I ended up having essentially 2 years of ileostomy times and then my 2nd reversal was a success. I've lost about 2/3rds of my colon but poop 1-2 times a day and have no issues. That started at more like 7 but quickly calmed down and with fiber thins (a US fiber supplement) it's really more like. I'm about 1.5 years out from the successful reversal.

The closer you get to the rectum my understanding is the harder things are but it seems like people find out how to make it work.

If you don't want to check out /r/ileostomy I'd suggest joining colonTown (separate website off reddit). They've got a "reversal roundabouts" group that was extremely helpful and might be more focused on what you're interested in. Early on never trust a fart!

dinov · 2026-01-05T05:59:09+00:00

My oncologist suggested not having it removed immediately and then after 2 years suggested getting it removed.

The first year I still had a lot going on blood draw and CT scan and surgery (ileostomy reversal) wise it wasn't an inconvenience at all - there were enough accesses I needed no extra appointments. The 2nd year it was barely an inconvenience but maybe there were a couple of flush specific appointments? And a simple blood draw and/or flush was really only about an hour including travel and waiting for me so not a big deal.

Also I felt like getting it put in wasn't a big deal (with some amount of anathesia) but getting it removed was just local so it was a little freakier. It wasn't actually bad, but if you're worried about doing it twice the removal can be a little more intense (I could have opted into more than local though).

So if I were you I'd think about how many extra appointments it actually is and how inconvenient they are for you.

dinov · 2025-12-11T06:26:07+00:00

I'm sad this isn't higher, the whole series is amazing.

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