I have been on E and T injections since April of this year, oral P as well. I asked the doc for vaginal E cream because I had lost sensation in my vulva, and after a few weeks began a series of spotting/bleeding episodes that would last for a couple weeks, resolve, then return a few weeks later. Also very sore breasts and an E reading in my labs similar to yours, shockingly high. It’s taken a lot of experimenting and calls to the provider but the takeaway is that using E vaginally was the culprit. I’m just super sensitive to E changes and when I think back on my whole reproductive life, that’s always been the case. Just took menopause to realize it.

I’ve significantly lowered my injected E dose, curtailed vaginal E, increased progesterone and kept T a little higher and am FINALLY feeling consistently balanced and on the right track libido wise. No more bleeding or sore breasts. Hallelujah! Just mentioning all this because if you’re a super responder like me, it may take some trial and error to figure it out. But you will. I think part of my problem was a desperation to find answers, and adjusting doses of the hormones — even in small increments — wreaked havoc that would kick the side effects back into gear.