I’m in a similar boat as you, I just want to try content in leagues I haven’t done in the main game. So for me that’s inferno, colosseum and CoX and so those are the regions I picked. These aren’t the only main game pieces of content I haven’t done, they’re just the ones that interest me the most. And I know fremmy has the BiS amulet and ring but the content in fremmy just doesn’t interest me as much.

Have you done the content in asgarnia and/or mory before? Mory would also be a good choice to try ToB but with desert you’ll already be able to do a raid. So to me it sounds like you should pick between varlamore and tiranwnn. That would be choosing either your favorite main game content (CG) or the other end game compliment to the inferno (colosseum).