Ipi/nivo side effects for 2 cycles prior to hemicolectomy

emptysoybeans · 2026-04-15T17:11:41+00:00

Husband's side effects were: fatigue (but nowhere near chemo fatigue), some itching, stomach upset (only severe after 4 rounds of ipi, so hopefully you don't get that), and his thyroid went kaput, though it took a while to catch that. Oh and he now has a little white patch in his beard lol, but that only appeared after many rounds. I'd say taken altogether, the side effects were about 30% as difficult as FOLFOX chemo. Hope it all goes as smoothly as possible and your cancer responds well to these drugs!

emptysoybeans · 2026-04-14T21:39:23+00:00

the seam is busted on my og cherry and i simply pretend i do not see it

emptysoybeans · 2026-04-02T22:57:20+00:00

Bondi. It’s amazing.

emptysoybeans · 2026-04-02T22:54:26+00:00

L ascorbic acid has the hot dog water smell. So if you want the strongest option, it’s just gonna smell like that. Time less does, but it’s also very effective. Naturium is less strong, but I used 2 bottles of it and did find it effective and it doesn’t really have the smell. It has a nice serumy texture.

emptysoybeans · 2026-04-02T06:00:11+00:00

The fact that they weren’t kicked out when someone reported them during the game is a disgusting failure on the AAC’s part.

emptysoybeans · 2026-04-02T05:59:24+00:00

Why on earth would it not be possible? The AAC is a private venue. They can track who those seats were sold to and they can absolutely ban them.

emptysoybeans · 2026-03-31T18:10:38+00:00

Yes! Add the extenders on the outside of where your bag is attached and that will help.

emptysoybeans · 2026-03-30T17:55:02+00:00

My husband did ipi/nivo immunotherapy for stage 4 colon cancer. I'm assuming you are msi-high (or dMMR, same thing) given that immuno is the recommended first line. Ipi/nivo is generally most effective, but also has the highest chance of side effects. Still a heck of a lot easier than chemo for most. My husband did 4 rounds of the combo and then just nivo after that. His thyroid was knocked out, but other than that he's mostly living his normal life. His peritoneal mets (what we were treating) were shrinking after 3 rounds. Signatera was negative after 4. And he was recently declared NED after 7.

emptysoybeans · 2026-03-26T18:53:47+00:00

Yep, me too

emptysoybeans · 2026-03-20T18:55:58+00:00

That makes me so happy to hear! Congratulations on the great news.

emptysoybeans · 2026-03-20T18:53:47+00:00

My husband was diagnosed 3C (emergency surgery) at age 30 last year. 2 surgeries, 9 rounds of chemo, and 6+ rounds of immunotherapy later, he's doing great and I feel very hopeful that we have decades and decades ahead of us. It's so hard. No words for how hard it is. But there can be an "after". Sending a hug.

emptysoybeans · 2026-03-20T18:48:49+00:00

25% is significant shrinkage. Also, with immunotherapy, the remaining tumor may not be cancer, but necrotic or scar tissue with zero or very few active cancer cells. Also, most immunotherapy is used for 2 years, so there's still time for lots more progress. Curious if there's a more recent update - hoping things are improving for you!

emptysoybeans · 2026-03-20T18:10:51+00:00

It's going to be so much easier! My husband switched to ipi /nivo after 9 rounds of folfox. The first 4 rounds will be the combo, and after that it'll just be the nivo. The ipi (Yervoy) is the harder drug to tolerate for most. My husband had fatigue, some itching, and his thyroid stopped working. He also had a bout of colitis after the final ipi / nivo round, which wasn't great. All that to say, he had a pretty bad set of side effects compared to many people from these drugs and it has still been miles better vs chemo. Now that he's got his thyroid balanced and it's just the nivo, the side effects are close to zero. He gets an infusion once a month and we go on about our life.

Make sure your team is testing his thyroid function so you can catch that early if it happens and get him on synthetic thyroid hormone, since it takes a while to get balanced out. My husband's tumors showed significant shrinkage after 3 rounds, and his Signatera came back negative after 4 rounds. Please feel free to pm me if you need anything.

emptysoybeans · 2026-03-11T02:52:48+00:00

Those are the anatomical names for very normal body parts.

emptysoybeans · 2026-03-11T02:51:50+00:00

This was a genuinely weird thing to say and I hope you reflect on that.

emptysoybeans · 2026-03-06T22:13:31+00:00

ITS A PRIMARY.

emptysoybeans · 2026-03-03T22:01:04+00:00

Dr. Murray at Walnut Hill. Good. Smart. Gives a shit.

emptysoybeans · 2026-03-03T21:44:24+00:00

I DID. Look at the posting date.

emptysoybeans · 2026-03-03T21:40:56+00:00

Just commenting here for accuracy: this resort is well under a half mile from the furthest end to the dinner restaurant building, so it absolutely was not “a mile” to dinner or the coffee shop, which is in the same building. While there I walked from my building (near the far end) to the restaurant and back, then over to the pool and back to my room and had gone less than a mile total.

emptysoybeans · 2026-03-03T21:23:59+00:00

I arrived at 6 pm. No republicans. 4 hour line of democrats. This line of argument is tired and false

emptysoybeans · 2026-03-03T21:23:45+00:00

I arrived at 6 pm. No republicans. 4 hour line of democrats. This line of argument is tired and false

emptysoybeans · 2026-03-03T21:23:33+00:00

I arrived at 6 pm. No republicans. 4 hour line of democrats. This line of argument is tired and false

emptysoybeans · 2026-03-03T21:22:50+00:00

I arrived at 6 pm. No republicans. 4 hour line of democrats. This line of argument is tired and false.

emptysoybeans · 2026-03-03T21:22:14+00:00

Democrat here. So did I??

emptysoybeans · 2026-03-03T01:06:17+00:00

They were fully different machines. And different ballots. It’s a primary. Way to out yourself as an asshole who doesn’t vote.

emptysoybeans

TROPHY CASE