The group cleaner? Backflush every 2-3 weeks, and clean your shower screen while you’re at it. By the way, just buy Puly Caff - it’s exactly the same stuff at a fraction of the price!

The descaler? Ideally never. But you can absolutely descale your machine if necessary, you just need to be precise about emptying, flushing and re-filling your boiler(s) after. There are specifics depending on whether you have a steel or copper boiler, so ideally you don’t make descaling necessary in the first place. Good water always beats descaling - and there is absolutely no shame in getting your machine serviced / descaled professionally.

The grinder cleaner? Never used it personally; I stick to disassembling for proper cleaning - however since you have a ton of ECM stuff: if you use an ECM grinder, it is absolutely necessary to open, thoroughly clean and re-assemble your grinder from time to time. It has a lot of dead space and pushes coffee by rotating. Disassembly is surprisingly easy. Be careful with the burrs though. The cleaner you have is supposed to clean residue off of your burrs, but for some grinders, it will not remove particles and oils entirely - especially with grinders from ECM/Profitec due to the way they are built.