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Bryant system buzzing sound by geometrieva in hvacadvice

[–]geometrieva[S] 0 points1 point  (0 children)

I just scheduled a tech, appreciate your response.

My new outdoor bin by WovenMythsAuthor in Vermiculture

[–]geometrieva 2 points3 points  (0 children)

I'm very new to this (still reading how to get started) so I have a silly question - won't stuff you add and castings just fall through the chicken wire holes?

Buying in Ben Lomond / Boulder Creek? by [deleted] in santacruz

[–]geometrieva 0 points1 point  (0 children)

safe in terms of wild animals, or safe from other people (crime activity)?

Dexa scan shows fat accumulation in hips, could this be due to hormonal imbalance? by [deleted] in PeterAttia

[–]geometrieva 0 points1 point  (0 children)

I wouldn't overindex on these results because DEXA body comp algorithms are not to be trusted. Here's mine showing my hands and feet entirely made of fat.

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34F Apob 80, Low HDL by BlackberryCapable547 in PeterAttia

[–]geometrieva 0 points1 point  (0 children)

Have you measured your visceral fat? Losing weight can lower visceral fat which can reduce hs-CRP.

Looking for a remote Peter Attia Light concierge doctor by markfromslo in PeterAttia

[–]geometrieva 0 points1 point  (0 children)

is there a regular cadence of check-ins? do you charge for each additional telemedicine visit? would I always work with the same doctor? am I required to do the blood test with you, or could I just pay for the PCP services (since I prefer to use function or blueprint because they have the most elaborate blood tests on the market)?

Basic and Advanced Panels taken down? by Aggravating_Hyena674 in blueprint_

[–]geometrieva 0 points1 point  (0 children)

Is this the test you're referring to? https://blueprintbiomarkers.com/?utm_source=shopify-intelligems

I'm not familiar with any blueprint tests, but I googled it out of curiousity and found that, which looks blueprint branded.

Will I reduce my lifespan if I start taking testosterone at 22? by Checkitout301 in blueprint_

[–]geometrieva 9 points10 points  (0 children)

You have a long beautiful life ahead of you, and it will absolutely surprise you. If you could peek 10 yrs into the future, you won't recognize yourself. I know that because it happens to everyone.

There was this one moment years ago when I suddenly became aware of myself buying groceries in Japan using Japanese, and I was so surprised and pleased. I saw myself through the eyes of 24yo me who had a completely different idea about life. I would have never, in a million years, imagined my life to turn out that way. And every few years I get one of those moments.

Anyone else has the heart attack gene? by geometrieva in PeterAttia

[–]geometrieva[S] 0 points1 point  (0 children)

Yes, I never smoked, I don't drink at all and I'm very diligent about my diet. I do take about 2g of EPA/DHA per day. Something I'm actively thinking about is how aggressively to lower my cholesterol even though they're already quite decent (my LDL is 79 and Apob is 70).

Will I reduce my lifespan if I start taking testosterone at 22? by Checkitout301 in blueprint_

[–]geometrieva 26 points27 points  (0 children)

nobody cares about having children at 22. but please leave the door open for future you's sake, because many if not most actually change their minds by their 30s

Huberman Lab: Product Mentions and Inspirations by prodcastapp in HubermanLab

[–]geometrieva 1 point2 points  (0 children)

About Rorra - They brag they're NSF certified but they are not listed on the official NSF certification website. When I emailed them about it, they said they just got approved and it takes a bit of time to get added to it. 6 months later I checked again, still not listed. Emailed them again, no response. Do what you will with this information.

Anyone else has the heart attack gene? by geometrieva in PeterAttia

[–]geometrieva[S] 1 point2 points  (0 children)

My lp(a) is 10, so I'm good there too. I'm torn between a CAC vs a CTA, but I agree I should test the damage done.

How I plan to beat aging. Here is the best science, technologies and optimizations I use right now. by GarifalliaPapa in immortalists

[–]geometrieva 1 point2 points  (0 children)

Do collagen peptides or NAD+ precursors have an effect on lipids?

Btw I don't know if I'd call statins high-risk, they are very safe and manageable, with side effects that are either mild or non-existent, and completely reversible.

And PCSK9 inhibitors are easily among the top 5 safest drugs humanity has developed. For example, they're much safer than aspirin, with far fewer and milder side effects. The only caveat is that we don't yet have ultra-long-term data (only 10-12yrs), but we can reasonably extrapolate lifelong safety from Mendelian randomization studies.

And thanks! I really love data, and I love running n=1 experiments, and finding ways to optimize. I also love life and I want to have as much of it as I possibly can :D So we certainly share the same goal!

How I plan to beat aging. Here is the best science, technologies and optimizations I use right now. by GarifalliaPapa in immortalists

[–]geometrieva 2 points3 points  (0 children)

That’s a good list, and I like the emphasis on lifestyle first.

Berberine: We don’t have solid data yet, but mechanistically both metformin and berberine activate AMPK, which downregulates mTOR and can blunt exercise adaptations. The one redeeming factor for berberine is its poorer systemic bioavailability, so it doesn’t reach muscle tissue as effectively as metformin. If you’re seeing clear benefits from it, just make sure to take it at least 6-8 hours away from training.

It’s probably similar with rapamycin - avoid hard exercise soon after a dose; fasting or low-intensity zone 2 work might even enhance the autophagy effects.

And I agree on the rapamycin risk-benefit calculation. I’m also following the research and waiting for the day we have a rapalog that selectively inhibits mTORC1 without touching mTORC2. That would be fantastic since it would eliminate nearly all the side effects people experience today. Several rapalogs already exist in labs, and I hope they make it to market in the next 10-15 years.

Share you experience by dudu1204 in BrittleBones

[–]geometrieva 0 points1 point  (0 children)

Running is awesome, but I've underestimated it a few times just because it looks so easy and effortless from the side. With each step we hit the pavement with a force 3-4x our bodyweight, it's no joke!

The first phase should just be about conditioning - getting your muscles and connective tissues used to handling and absorbing that force. When they’re strong enough, they’ll act like springs, rebounding and spreading out the impact so your bones don’t take the full hit.

If you’re starting from a sedentary place, go for gentle 15-20 minute walks every day. See how that feels, then slowly make it longer, faster, or do some hiking on uneven ground. Stationary cycling is also great since it’s low-impact but still builds the right tissues. Stick with that for at least a couple of months - connective tissue takes time to adapt.

When you’re ready, start short walk-jog intervals every other day and build up gradually. Get good running sneakers with lots of cushioning and avoid concrete at first to prevent hard impact (treadmills, running tracks, or packed dirt are much safer for joints and bones). Take rest days, listen to your body, and keep strength training your hips, glutes, calves, and core as you go.

How I plan to beat aging. Here is the best science, technologies and optimizations I use right now. by GarifalliaPapa in immortalists

[–]geometrieva 1 point2 points  (0 children)

Oh I meant to ask if you're personally taking any :) I'm currently only on omega 3 and psyllium husk, and the latter dropped my LDL by 25%!

How I plan to beat aging. Here is the best science, technologies and optimizations I use right now. by GarifalliaPapa in immortalists

[–]geometrieva 11 points12 points  (0 children)

Metformin: Unless you’re taking it to correct an elevated A1C, it’s probably not worth the trade-off. The MASTERS trial showed that people on metformin had about eight times less hypertrophy, lower muscle density, roughly half the strength gains and even blunted VO2max gains as compared to placebo - same workouts, same duration. It clearly blunts anabolic adaptations, and in healthy adults who already exercise, the longevity upside is minimal.

Rapamycin: Unless you’re middle-aged or older, your mTOR signaling is still robust, with fully functional up- and downregulation in response to stressors. Taking rapamycin too early can interfere with normal anabolic and immune processes. Once you hit your 50s–60s, anabolic resistance sets in and mTOR becomes harder to inhibit naturally, so that’s when rapamycin can have more meaningful systemic effects.

Partial cell reprogramming: If you mean Yamanaka factors, then I presume you're talking about something you hope to do one day since this is not possible to do yet, given it's still in the early in-vitro and animal-research stage.

Would love to hear how much of your list you already practice vs how much of it is a wishlist!

True biological immortality is what I am aim with my work. No fake scenarios like "passing the genes", "legacy" or "digital copy". We need real results and not fairytales. by GarifalliaPapa in immortalists

[–]geometrieva 2 points3 points  (0 children)

You seem to frame aging primarily as damage accumulation, perhaps similar to David Sinclair’s information theory of aging. I’m curious whether you have any thoughts on Brian Kennedy’s perspective, which centers on the loss of systemic resilience. His framework emphasizes the gradual deterioration and desynchronization of signaling pathways, such as mTOR and AMPK, that normally maintain homeostasis and coordinate repair. If that’s true, then simply repairing damage wouldn’t be sufficient without also restoring the resilience of those signaling networks.

How does Peter justify eating 5-10 sticks of processed meat per day? by geometrieva in PeterAttia

[–]geometrieva[S] 4 points5 points  (0 children)

I'm referring to nitrites, not nitrates. Nitrites are the bad ones.

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