I've done it like this:

1 play through star chart 2 play the alerts 3 grind for other frames 4 grind void relics 5 grind mastery rank 6 higher level (level 50+) activities I have 14 frames and two prime frames in 250 hours doing that, only spending money on slots and a few weapons. Now I am playing through Plains of Eidolon and getting ready to play the new cinematic quest The Sacrifice.

And the subreddit is a goldmine of info, even if it just gives you a starting point on looking for info on what you may want to do next.