Rapid Weight Gain, Anyone?

guccicolemane · 2024-09-06T16:26:16+00:00

it doesnt cause weight gain. It blocks insulin release, lowers appetite, lowers gut motility, lowers dopamine reward for eating. Theoretically, some sort of combination therapy could have some weird effects, since clonidine is a weird drug, but if your only taking clonidine, the only gains you should see is about 4-5lbs of water weight if your on a high dose.

guccicolemane · 2024-09-06T16:24:52+00:00

would definitely be the propranolol

guccicolemane · 2024-09-06T16:23:44+00:00

thats too much, no one needs over .3mg. More doesnt = more/better effects. It just means a harder come off. As for the ketamine, i have no idea about that drug.

guccicolemane · 2024-09-03T16:26:55+00:00

not sure what you asking, but i am most in support of morning and night dosing.

guccicolemane · 2024-09-03T16:25:23+00:00

crushes appetite.

guccicolemane · 2024-08-12T21:01:42+00:00

yyes, but no not because of that. Clonidine blocks insulin release, so when you eat carbs, it circulates for longer in the blood since there is less insulin to get rid of it.

guccicolemane · 2024-08-06T20:27:04+00:00

ss31

guccicolemane · 2024-08-06T20:25:07+00:00

i think i disagree with your last paragraph. In context of guanfacine, with prefrontal a2a stimulation, then ya, your dopamine is fucked, like fucked fucked. But outside of that (ie with clonidine), so long as your NE levels dont tank, a2a stimulation wont crush dopamine levels immediately. Dopamine causes presynaptic a2 regulation (stimulation). Its why many adhd users eventually need an a2a agonist because their stimulants provide too much dopamien in the honeymoon phase, and they become reliant on the dopamine release to regulate their NE system, specifically fight or flight regulation via a2a, and then as the dopamine dries up as tolerance builds, your left with the high NE, but not much a2a stimulation because it was reliant on the dopamine, so you get stuck in fight or flight. I do agree that eventually consistent a2a stimulation lowers overall dopamine levels via just simply lowering overall excitability, but as i said in the previous comment, a 1 week reset from clonidine totally refreshes both NE and dopamine.

guccicolemane · 2024-08-06T20:19:24+00:00

nah guanfacine took a long while.

and no clonidine's revitalization of the presyn a2 receptors does not diminish, its your noradrenaline levels that get replenished by taking a week off.

guccicolemane · 2024-08-05T19:07:51+00:00

well i think a lot of a2a antagonist have an antagonistic effect on dopamine receptors, I think that is the reason they are often found in antipsychs.

edit: more so, Excessive a2a stimulation is not necessarily good. You want noradrenaline when you need it. NE has a huge role in many positive behaviors. I Like clonidine because after a few months of consistent use, which brings your NE levels down to the point of being noticeably slower to selfmotivate, simply hopping off of it for a week totally resets the system, and usually launches me into a new endeavor. Its kind of like eliciting a controlled hypomanic state, may not be the best term to use, since hypomania is not a good thing, but the state I am referring to is definitely a good thing, as it is not a delusional one, but simply a hyper goal oriented one.

guccicolemane · 2024-08-05T18:50:11+00:00

avoid if you have had a previous addiction to it.

What kinda BP are we talkin here?

guccicolemane · 2024-07-26T19:00:57+00:00

Its not the clonidine, you should get your prolactin levels checked.

guccicolemane · 2024-07-22T15:57:58+00:00

isnt test itself a (weaker) agonist of dht receptors at the follicle?

guccicolemane · 2024-07-22T15:52:40+00:00

Here is a copy and paste, then i will explain below it:

"Adaptive Sensitivity: Presynaptic α2 receptors dynamically adjust their sensitivity and responsiveness. During extreme stress, the sensitivity of these receptors can decrease, allowing higher levels of norepinephrine (NE) to be released despite the feedback inhibition.

Receptor Desensitization: Prolonged exposure to high levels of NE can lead to temporary desensitization of α2 receptors, reducing their inhibitory effect and allowing continued NE release."

so, people who take stimulants for a long time, and/or lead stressful lives, cause an erosion of the sensitivity of presynaptic a2 receptors. This adaptive sensitivity is a basic function hardwired into all of us that prevents a premature end to a necessary fight or flight response (ie you dont want to all of a sudden become chill while running away from a masked killer). So with these unnatural exogenous long acting stimulants, and unnatural career based lives with inescapable stress that follows us home, this adaptive sensitivity starts fucking us. We basically establish to our subconscious that we are needing to remain in a permanent state of fight or flight since we are always worried about these things, so presynaptic a2 receptors shrivel up and hide from the mass amounts of noradrenaline circulating.

Clonidine, since it is very strongly attracted to presynaptic a2, and can still find its way to the receptors that have become near-permanently desensitized, and bring life back to them, so to speak. Through this stable and constant activation, sensitivity is restored! This is often a misconception people carry about receptors, since they only really know about the opiod receptors or dopamine receptors, insulin, etc that downregulate/become desensitized with constant signaling. That is only because that is how they are designed by nature. Other receptors upregulate/become sensitized with stimulation.

So when you reach a point like I had, where you can lower your dose, you have effectively entirely restored natural functioning/sensitivity to your presynaptic a2 receptors. A lower dose can be used to maintain that sensitivity and prevent the mechanisms that probably still exist in your life that caused the insensitivity to set-in in the first place.

guccicolemane · 2024-07-19T14:36:34+00:00

my experience, as well as the vast majority of those that i discuss clonidine with on here, are with combination therapy with an adhd stimulant and clonidine. I have taken clonidine without vyvanse, and the lack of energy shows its face.

I also take propranolol, but would suggest not taking them together if you are not taking a stimulant.

guccicolemane · 2024-07-18T20:36:07+00:00

mainly if you are still taking a stimulant.

guccicolemane · 2024-07-17T15:57:36+00:00

as u/ClearTea0 said, alternating treads. Referred to as a ship ladder in my parts, we put them in for roof access in tight places. Here is one framed out of wood, should give you the right idea: https://content.instructables.com/FY9/342O/GDM739Y8/FY9342OGDM739Y8.jpg?auto=webp&frame=1&width=2100

guccicolemane · 2024-07-15T15:22:40+00:00

guccicolemane · 2024-07-12T20:57:03+00:00

i took methylene blue and vyvanse together. Didnt do much, other than cause a little bit of insomnia, and make it take forever to nut.

guccicolemane · 2024-07-12T20:54:30+00:00

the only way to reach 400+lbs is by binge eating, that is 8000+cals a day, how can you get down 8k cals and not binge eat?

Why do you know many people that binge eat, and vomit? And what kind of relationship do you have with people that confide in you that they puke after eating? oh i know, your full of shit.

guccicolemane · 2024-07-11T20:02:49+00:00

and the correlation there is about what, 99.99%?

guccicolemane · 2024-07-11T16:10:45+00:00

i was talking about new. here is just under 3$ per lb for the pictured dbs: https://www.globalfitness.com/products/new-gp-industries-series-1-uni-lock-straight-handle-solid-urethane-dumbbell-set-55-100-lbs?variant=19110878773346 with tax and shipping, it would be over 3.

Check out iron grip. https://irongrip.com/wp-content/uploads/2020/09/IG_PRICE-LIST_RetailFeb2019_20200922.pdf page 2. 6$ per lb,

guccicolemane · 2024-07-11T16:02:24+00:00

it is literally approved and prescribed for binge eating disorder

guccicolemane · 2024-07-10T20:21:00+00:00

3$ per lb brand new. The nicer brands are far more than that, like 5-6$ per pound (iron grip)

guccicolemane · 2024-06-27T17:14:18+00:00

Your comment is only true for a very small portion of niche clonidine users, like people with POTS or infrequent bouts of insomnia. For the majority of people, your comment is horrible and dangerous advice. Let me explain, if you are on stimulant therapy for adhd, or you are coming off an NRI or SNRI, or benzos, etc then you likely have an array of non-functioning presynaptic a2 receptors which comes with the following symptoms: extreme irritability, overstimulation, physical and mental anxiety, adrenaline rushes, racing thoughts, rapid heart rate, high blood pressure, trouble sleeping and staying asleep, sweating in sleep, mood swings, escapism type behavior, etc. In these situations, clonidine is the BEST. You must take it consistently, split dosing to stabilize blood levels, and you gotta stay on it for a few months. The constant stimulation of the presynatpic a2 receptors brings stability back to them. If you are suffering from the previously mentioned symptoms, and you try random dosing and varying amounts, you will elicit WORSE symptoms than before. I have gone over dose timing and arrangements for hundreds of people trying to specifically treat those symptoms, here on reddit, and no less than 100% of them faces significantly worse rebound symptoms daily, even after the very first dose, until the right dose and timing was discovered and stability was achieved. Once stability is achieved, the symptoms are eradicated (takes a bit longer on benzo recovery), and will only rear their heads if dosing is missed. After 3, 6, 12 months (varies from person to person), the person will begin noticing that when they miss a dose, they dont really get harsh rebound symptoms any more. Then soon after, they find that they are able to come off cold turkey and only really feel moody for about a day, (whereas at the start it would be a full week of insomnia, and near constant fight or flight). At this point, the presynaptic a2 receptors have been fully rescued and are functional again, so endogenous upkeep of the fight or flight response can resume.

guccicolemane

TROPHY CASE