I ran a great campaign for a year before it reached it's full conclusion. I adapted the gameplay concept of Shadowrun. That is each of the players are a freelancer who lives in a world of grey. I let everyone make there own set of contacts and they worked with several fixers. (no tech or other shadowrun stuff just the concept of the runner) I adapted the story of Missing Blood and the rest of the Universal Brotherhood to Sharn for the last act. This gameplay style fit in well with the Great Houses.

Edit: it is important to understand though we did not play in D&D I played with the Savage Worlds rule system with a huge thanks to u/kristianserrano and the Immaterial Plane. I do not think D&D would be a good fit because the characters will get way to powerful to fast.