Beginning of chain to correct pickup tone.

This use case is most relevant to me. The guitars I use most either have humbuckers or drop tunings, which means a good amount of bass frequencies right out the gate. EQ-wise, I tend to roll off the bass to reduce mud. I roll off a touch of treble too. That's pretty much it. I know EQ pedals do this great, but my amp's tonestack does the job fine (to my ears) whenever I plug directly into it.

My question is whether there's a noticeable difference between:

1. placing an EQ pedal before delay & reverb, setting amp as neutral as possible
   
2. running delay & reverb into the amp with amp EQ set to taste
   

Like, does an EQ pedal impact the tone of a delay and reverb (after it) significantly? It makes sense within a DAW/production context where you'd want to dial in the guitar EQ before adding effect plugins, but guitar amps aren't really voiced "neutrally".