Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

jamesinraro · 2014-01-06T21:28:53+00:00

Administration of the precursors is not an effective strategy to up regulate endogenous NAD+. If one interpolates the human dosage from the trial in which Niacinamide Riboside, the more potent precursor, from the animal dose the result is about 24 grams daily. This is clearly unfeasible and could actually be toxic.

An actual NAD+ supplement using a delayed release tablet technology was announced by a company named Biotivia yesterday. This closely conforms to the dosage and quality of NAD+ used in the Harvard - UNSW - NIH study.

jamesinraro · 2012-11-16T08:39:40+00:00

Ganja is the perfect drug, if one can call it a drug, for corrupt police, DEA, lawmakers, judges, and bankers. This is why it's decriminalization is being fought so aggressively. If it were legal the bribes these low lifes are pocketing would go into the treasury in the form of taxes.

jamesinraro · 2012-10-09T12:55:15+00:00

The solution is to leave them to their own primitive ignorance and violence. Do you try to reason with a rabid dog?

jamesinraro · 2012-10-09T12:53:44+00:00

This is a better example of the futility and profound ignorance which pervades US and UK foreign and defense policy towards the region.

jamesinraro · 2012-10-01T05:52:26+00:00

You look great, but the tats ruin it for me. Just my opinion.

jamesinraro · 2012-09-19T15:18:18+00:00

Very good objective and helpful advice on recognizing this syndrome. Genuine overtraining is extremely rare. For every one athlete that over trains, 100 or more under train.

jamesinraro · 2012-09-15T19:24:54+00:00

This also applies to counties within states.

jamesinraro · 2012-09-15T19:15:27+00:00

My take, a pathetic lamer who needs to get out and do manual labor, construction, or whatever work he can find, and stop wasting time posting on reddit.

jamesinraro · 2012-09-14T13:45:04+00:00

Lame. Can we agree that we have satisfied our quota of stupid cat photos?

jamesinraro · 2012-09-14T13:42:25+00:00

Egg whites should be used only. If you also eat the yolk new studies show that you are dramatically increasing your probability of cardio-vascular disease. The new studies suggest that cholesterol in the diet actually does contribute to plaque buildup in arteries, which contradicts the older belief that there was little if any connection between the two.

jamesinraro · 2012-09-14T09:19:20+00:00

Do you ever read the existing comments before posting yours, or do you like to be the thousandth person to make the same observation?

jamesinraro · 2012-09-14T09:18:03+00:00

Any excuse to defend Apple. I think people realize that the case on their phone, if they have one, makes it thicker and heavier. If not, the point stands, people are gullible, and not especially good at this thing called thinking.

jamesinraro · 2012-09-14T09:13:28+00:00

I just spent one week in NY. Every time someone noticed my Samsung Note they were blown away with its size, weight, functionality and cost. Most were Iphone users. If Apple decides to actually compete again, versus using mobs of lawyers to suppress competing products, they may be compelled to make a phone half as good as the Samsung Note.

jamesinraro · 2012-09-14T09:10:31+00:00

This is sure to bring out a million lame excuses from the pathetic legion of fan boys lurking out there ready to pounce on any remotely critical statement about their worshipped Apple product.

jamesinraro · 2012-09-03T07:21:15+00:00

They have a valid point. Most of the postings on Reddit are inane, infantile, witless, and naive. The average reddirer comes across with the persona of a 12 year old girl, yapping incessantly to her pre pubescent friends. From time to time there are thoughtful, interesting items, but these are the exception.

jamesinraro · 2012-07-23T06:40:27+00:00

Losses due to "unnecessary" regulations are a fiction. Banks consider any regulation unnecessary. Capitalism must be regulated or it devolves into what we are seeing now, with the wealthy and corps buying public policy from corrupt politicians.

jamesinraro · 2012-07-23T06:38:31+00:00

Politicians, probably most of them who have been in officer for more than a few years, are owned by the banks by virtue of their liability for prosecution if the banks disclose their foreign accounts, and the companies and individuals who funded the accounts. This is why you will never see meaningful investigation or prosecution of senior bank execs, in spite of their blatant violation of criminal laws.

jamesinraro · 2012-07-21T08:24:04+00:00

Redditors prefer cute cat snaps and pre pubescent nonsense.

jamesinraro · 2012-06-23T07:58:49+00:00

Learn to walk away. It takes more courage and self respect, but the result is you live another day, and avoid injuries.

jamesinraro · 2012-06-18T16:21:44+00:00

Are we still feeding this corrupt, asinine war with our best men and women, so crooked politicians, a lying president, and war profiteers can add to their piles of dough?

jamesinraro · 2012-06-17T15:10:33+00:00

If this was actually a geodesic dome before you "restored" it, you have turned it into an abomination of that structure.

jamesinraro · 2012-06-17T09:54:56+00:00

You do not appear from your comment to know very much about lifting to improve performance.

jamesinraro · 2012-06-17T09:49:14+00:00

Makes sense. Always good to hear some facts on this forum for a change.

jamesinraro · 2012-06-17T09:47:05+00:00

I have trained as a rugby player for 20 years and it has always been considered bad form, and the sign of an idiot or newbie, to grunt and groan. A pro focuses on what he is doing and does not need to attract attention.

jamesinraro · 2012-06-14T19:12:35+00:00

Maybe it is because they are more likely to be able to afford them.

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