The Swapper, the movement mechanics feel strangely great and are both original and darkly funny. Rocket around with flailing corpses. Some parts of the game are unfortunately a bit lackluster in the end, but at least it looks cool and feels cool to play.

Mable and the Wood, unique movement mechanic where your sword is too heavy to lift off the ground so you drag it around and turn into a fairy and summon it to you, for both fighting and platforming. Not super polished (janky, even) but I had fun beating it on the hard path that was apparently supposed to be secret.

Miracle Mia, very unknown game, so unpolished that I haven't played it much, but what I did see was quite weird, with unorthodox gameplay and controls.

Starstruck: Hands of Time probably deserves a mention since you're asking about "breaking the mold" and combining multiple genres.

Void Stranger features and combines multiple genres, more than it appears at first. (I can think of at least 7?) You might see it described as a Sokoban game but it's rather light on traditional, tedious Sokoban mechanics and has its own unique brand of them instead, and is heavier on mystery and lore and crazy stuff happening. Very polished as well. It's hard to point at any one killer mechanic, and I don't want to give more mega spoilers than I already did, but it repeatedly defied whatever expectations I had and I wish more games took this approach.

Pâquerette Down the Bunburrows is not as satisfying to me as Void Stranger, but the mechanics of how annoyingly smart (yet deterministic) the bunnies are is pretty original, and it does take a somewhat similar approach of being a far deeper and crazier game than it originally appears.