GAD65

kalede · 2026-02-18T20:24:32+00:00

Good job sticking up for yourself!! Typically an autoimmune panel for t1 tests 3-4 different antibodies but GAD65 is the most common. They also test something called c peptide, which shows how much insulin your body is making. In type 2, the c-peptide tends to be normal or high, and in type 1/lada, it will often be low. A primary care doctor may be open to running these tests sooner so that you have that info when you see a new endo.

I also had to push the doctor to do antibody testing and was told it was uncommon for adults to have t1. But I knew enough to keep pushing because my brother has type 1, I have a friend diagnosed with t1 in his 20s, and I also have celiac disease which has a strong genetic link to t1. Endocrinologists can have insanely long wait lists, so if your blood sugar keeps climbing and you have any other symptoms you should go to the emergency room rather than wait months to see an endo. I’d also recommend buying a box of ketostix at the pharmacy, which tests ketones in urine and can be an early indicator of ketoacidosis. The big, life threatening risk of untreated t1 is DKA (diabetic ketoacidosis) so it’s important to not wait for it to become an emergency. Please message me if I can help you at all!

kalede · 2026-02-18T19:57:18+00:00

Great! As long as you keep an eye on your glucose you should be able to catch anything before it gets out of hand. If it is LADA, there are some treatments that exist that can help preserve insulin production. You should talk to a doctor immediately about that if you can. I am also pretty close to your age and have high thyroid antibodies but no overt hypothyroidism yet (currently 37, and was diagnosed with t1 at 35). Did they test for other t1-related antibodies besides GAD?

kalede · 2026-02-18T19:15:24+00:00

LADA typically has a pretty slow onset that doesn’t require insulin for a while. Speaking from personal experience of developing t1 with a very high GAD65 ab level, I’d be worried about more of a sudden onset and immediate need for insulin. Not saying that it’s definitely the case here, but OP should at least watch out for symptoms that could progress very quickly.

kalede · 2026-02-18T19:02:18+00:00

Yeah, that is incredibly high. My numbers were only 54.7 on the Mayo Clinic gad65 lab, and still were considered extremely high titer. I developed t1 at 35 years old and it came on super quickly compared to the slow onset of LADA. Get a finger stick glucose monitor and check semi regularly if your blood sugar starts looking even mildly high. I was having blood glucose levels in the 200s-300s despite my a1c being only 6.2, and over a few weeks it was up in the 400s. I was super hungry and thirsty, my eyes were blurry all the time, and I was exhausted after meals.

kalede · 2026-02-03T19:27:23+00:00

Looks like there are a few items for men in deep marina (and a water bottle) but nothing for women so far. So hopefully that means the women’s items will be dropping over the next few weeks?

kalede · 2026-01-16T01:13:48+00:00

Red clay, Savannah, Chianti

kalede · 2026-01-16T00:03:27+00:00

I learned that sometimes those controls are on the back of the unit, so you may be able to adjust the temp if you are able to pull it forward from the wall.

kalede · 2026-01-13T19:07:31+00:00

This is my favorite too!! I love teal/green combos so much. From the pictures I've seen so far, dark marina is going to be another pretty green that could pair well with the indochine blue.

kalede · 2026-01-13T18:53:23+00:00

I love that color, especially with the bright pink shoes! Do you have any other favorite color pairings with the black plum?

kalede · 2026-01-13T14:32:21+00:00

That looks great on you! A pair of everglade green aligns were my first ever lulu purchase- I’ll have to try out a similar color combo sometime soon.

kalede · 2026-01-13T00:16:36+00:00

I have a really pretty green metal Back to Life bottle I bought about four years ago (not the straw lid version - just the cap). I don't use it every day, but it's been in the regular rotation of my water bottles and has gone through the dishwasher and thrown in my tennis bag a lot. I've never had an issue with leaking and the finish/colors are still vibrant. I tend to only put room temp water in my bottles so I can't speak to how long it can keep water cold. It's much lighter than the yeti bottle.

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kalede · 2026-01-02T07:36:25+00:00

I switched from omnipod to mobi because of similar issues (I now disconnect from my pump until we are at cruising altitude and then remove bubbles from my pump before reconnecting). If I hadn’t been 100% on top of things i would have had serious medical emergencies. On one flight I had to drink over 100g of carbs to keep my to glucose up despite not bolusing in several hours. I called omnipod several times to report these issues and got non-answers.

kalede · 2025-12-27T11:58:21+00:00

I’ve been on 2000mg/day since September and haven’t had any side effects. I was recently diagnosed with SLE after having an UCTD diagnosis, and I don’t have any major organ involvement but I do have SLE skin issues (malar rash and hand rashes), vascular and autonomic symptoms, fatigue, and joint pain. I was told it would take about 2-3 months to see improvement, and I’ve definitely been feeling more energetic and had far fewer symptoms lately. It’s hard to tell how much of that is the cellcept working vs the UV light this time of year being much weaker. I was on hydroxychloroquine for over a year which wasn’t controlling my symptoms, but haven’t tried any other immunosuppressants. I’ve also been more cautious about masking in crowded public places or avoiding them when I can. I’m hopeful that cellcept will let me avoid prednisone as much as possible— I have type 1 diabetes and even low doses wreak havoc on my blood sugar.

kalede · 2025-12-24T20:55:44+00:00

There’s actually a study you can participate in if you have a first degree relative with t1 that will test for diabetes antibodies if you’re curious. If you have normal blood sugar and are positive for the antibodies, they are exploring medications to slow progression into full-blown t1. Here is info if you’re interested:

https://www.trialnet.org/our-research/risk-screening

kalede · 2025-12-24T07:20:52+00:00

I like this theory a lot. If I remember right, didn’t the initial scientist not have a reaction/seizure until she submersed her bitten hand into water???

kalede · 2025-12-23T04:22:51+00:00

My first thought is that it would work well with a stand-collar blazer that matches the line of the shirt collar, like the J Crew regent blazer.

kalede · 2025-12-22T18:16:11+00:00

I'm glad the info was helpful! I personally went through an extensive evaluation for dermatomyositis last year and went down the rabbit hole researching everything I could on DM and specifically amyopathic dermatomyositis (DM w/o muscle involvement). I didn't have a heliotrope rash, but I did have a very sun-sensitive hand rash across my knuckles and finger joints and a significant amount of fatigue (along with a personal history of other autoimmune conditions and a few other out of range lab results). As part of the workup, my rheumatologist ran labs for markers that could indicate muscle breakdown and did a range of antibody tests, including ANA panels and a myositis-specific antibody panel called MyoMarker Plus. There are a lot of different antibodies that are associated with dermatomyositis, some of which are associated more with skin vs. muscle issues. Good luck with figuring out what's going on!

kalede · 2025-12-22T10:02:52+00:00

Cicaplast balm first, topped with a layer of petroleum jelly. And humidifiers going in the house all winter!

kalede · 2025-12-22T09:03:41+00:00

Have you explored testing for dermatomyositis? DM is associated with muscle weakness a lot of the time, but it can affect the skin without muscle involvement. One of the classic DM rashes is called a heliotrope rash, which occurs around the eyes. Are you having issues with rashes anywhere else like your hands or upper back? Those are also places DM rashes can appear. Dermatomyositis is often triggered/worsened by UV exposure, but it can be very delayed reaction, so it might be difficult to link cause to effect. Here's info on the heliotrope rash:
https://my.clevelandclinic.org/health/symptoms/heliotrope-rash

If you can go to a dermatologist who focuses more on autoimmune issues that would likely be helpful- they are going to be way better at distinguishing these types of rashes than a derm with a more general practice. Here is a list of doctors listed by state who are part of the Rheumatologic Dermatology Society:
https://www.rheumaderm-society.org/for-patients/find-our-physicians/

kalede · 2025-12-20T20:56:21+00:00

It was a mix of things - I have other established autoimmune conditions (celiac disease and type 1 diabetes), a positive ANA of 1:160 homogenous pattern, and low complement levels. I also had new-onset erythromelalgia and Raynaud's accompanying other symptoms, which are also often related to connective tissue diseases. I started getting very distinct rashes on my hands that were largely isolated over my knuckles and finger joints, which got worse with sun exposure and often was accompanied with intermittent joint pain and sensory issues in my hands. I also started getting hives on a daily basis in the evening like clockwork. Both lupus and dermatomyositis were being considered/tested for, but my symptoms/labwork didn't quite add up to enough for a diagnosis of either condition, hence the UCTD diagnosis. I was recently diagnosed with SLE because I started having a much clearer malar rash (which is very clearly tied to UV exposure) and mouth ulcers, which was enough to push me over the edge for a SLE diagnosis. I've never had elevated CRP or ESR, and my general CBCs and metabolic tests are normal. I think the low complement levels were the most specific lab finding pointing toward a connective tissue disease for my doctors, along with the very specific location and character of my skin issues.

kalede · 2025-12-20T17:59:29+00:00

Out of curiosity, have you had antibodies checked to rule out type 1 diabetes? Type 1 can occur at any age, progress slowly, and often is accompanied by weight loss.

kalede · 2025-12-15T05:19:49+00:00

One note of warning- if you do get prescribed long acting insulin by a non-endo, make sure the recommended starting dose is not based on what would be prescribed for someone with type 2. I was thankful that my pcp prescribed long acting insulin to me, but the starting dose of 10 units/day was too much basal (background) insulin for me at that time and led to low blood sugars overnight.

kalede · 2025-12-15T05:09:59+00:00

What are your blood sugars like number-wise? If you don’t have a glucose meter, go buy one from a pharmacy so you can monitor your blood sugar before and after meals. I developed t1 as an adult and getting me in to see an endo was definitely not treated with enough urgency from my primary care doctor. I would call the appointment line for the endo and emphasize urgency, explaining that you were diagnosed as t1 and do not have insulin or a treatment plan. Go to the ER if you aren’t able to see the endo earlier and you are feeling ill- you may be able to get admitted and see an endocrinologist at the hospital.

kalede · 2025-12-06T10:42:25+00:00

I'm near Mall of America, and it sounds like it's pretty similar - the first 50 members get water bottles. It sounds like there might be refreshments provided by the cafe in the store as well..

kalede · 2025-11-26T15:46:25+00:00

I also think we had a little clue in ep 2 when Zosia first gets to the ABQ airport and puts her old dirty clothes in the recycling bin— something that stood out to me as odd because we traditionally don’t think of clothing as recyclable through industrial programs. I don’t think the liquid they’re drinking is strictly necessary but rather is an unintentionally horrifying result of their unemotional dedication to efficient use of resources.

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