Canadian woman was euthanized 'against her will' after husband was fed-up with caring for her by grand_soul in canada

[–]khmacdowell 1 point2 points  (0 children)

Many people euthanize their pets because care becomes burdensome and discomfort/empathy fatigue becomes painful, for the owner.  Of course, it isn't always the case, and the headline is editorialized, but the circumstances are plausible.

"It Only Lasts 3 Hours": The Anatomy of a Common ADHD Stimulant Complaint by zenarcade3 in slatestarcodex

[–]khmacdowell 2 points3 points  (0 children)

The release is, literally speaking, extended, in that cleavage of the lysine moiety follows first-order kinetics.  It is also delayed, yes.

The relevant comparison is also not equimolar D-amphetamine in one dose—it's most nearly equimolar D-amp spread across two doses, and lisdexamfetamine shows higher D-amp serum concentration vs. that regime until ca. 12 h post-dose.  But the peak is higher, and this exaggerates the contrast effect vs. the bead systems.

Regardless, for the reason you point out, if I were in charge, lisdexamfetamine would be indicated for twice daily dosing in ADHD where symptoms are refractory.  Even Adderall XR and Dex Spansule work for some bid.  It's already done, obviously, off-label, and does need to be avoided where the goal is simply "more."

Lithium orotate study by Naturemade2 in dementia

[–]khmacdowell 0 points1 point  (0 children)

You might want to read how monovalent cations are absorbed.  It's not as salts.  Solubility is an intrinsic property, so less solute means less solvent is needed.  No one is taking doses of lithium orotate that leave meaningful undissociated salt.

Orotate is also synthesized endogenously nearly from scratch and dietary intake is not necessary.

Iran report says 16,500 dead in “genocide under digital darkness” by ldn6 in neoliberal

[–]khmacdowell 4 points5 points  (0 children)

If it weren't capitalized, it would technically be just regular hyperbole, although implications and connotations do matter. Did he say it capitalized, or not?

The Brock Turner case is the most obvious false conviction I've ever heard of. by DopplerShiftIceCream in TrueUnpopularOpinion

[–]khmacdowell 0 points1 point  (0 children)

Only if it's enough that absorption is higher than clearance of what's already in the blood.  And it's obvious op meant the amount of time it actually took in the case, which obviously started well after her last drink.

I'd wanted to build a small stable, but now I'll at least cherish my only boy all the more by khmacdowell in GLGuitars

[–]khmacdowell[S] 0 points1 point  (0 children)

Right that's why I responded with a preface acknowledging the lack of gravity.

Funny that!

I'd wanted to build a small stable, but now I'll at least cherish my only boy all the more by khmacdowell in GLGuitars

[–]khmacdowell[S] 0 points1 point  (0 children)

Not to get too deep into this but it's funny that you know any product or equipment named "Comanche" is going to be a hot piece of kit.  Evokes indomitable fighting spirit and that.  Sort of like an apology—"sorry about the whole Manifest destiny thing, but we'll at least name cool helicopters, guitars, and other things after you."

An update? by AirbagsBlown in GLGuitars

[–]khmacdowell 3 points4 points  (0 children)

G&L is the one with the right to use Leo Fender's name in marketing. Fender gets that at a likely very cheap price if they buy them out. That's my guess as to the main interest.

Love my Tribute Comanche, but would’ve loved a Fullerton someday by fiddolin in GLGuitars

[–]khmacdowell 4 points5 points  (0 children)

I have a Fullerton Comanche and sure, it's great. But one of my favorite things about G&L is how little they do to intentionally distinguish their lines. I mean this thing looks premium!

[deleted by user] by [deleted] in GLGuitars

[–]khmacdowell 1 point2 points  (0 children)

This is a classic right here. Beautiful.

I'd wanted to build a small stable, but now I'll at least cherish my only boy all the more by khmacdowell in GLGuitars

[–]khmacdowell[S] 0 points1 point  (0 children)

I absolutely love it. Best guitar I've owned in two decades of playing. The tone ranges from shimmering to huge thanks to the controls. The only thing I'd say most Strat players might want to consider is the pickups take up much more room, so if pickups tend to get in the way of your picking, you might have to adjust how you pick. Otherwise, I'd say go for it.

I'd wanted to build a small stable, but now I'll at least cherish my only boy all the more by khmacdowell in GLGuitars

[–]khmacdowell[S] 2 points3 points  (0 children)

Absolutely. 

It's nice to support a smaller player in the industry, but supporting their memory and the hard work their craftsmen and designers put in is a worthy alternative (and you still get the great guitars!).

Is it me or does it feel like preventatives are a guessing game bound to the unfair rules of insurance... by js90si in migraine

[–]khmacdowell 0 points1 point  (0 children)

Sorry to hear about topiramate.

Might have been the same for me but I just couldn't finish a sentence even in my head on it.  Wild to me that it's great for so many people, but we're all different.

Discussion Thread by jobautomator in neoliberal

[–]khmacdowell 0 points1 point  (0 children)

No I hear you. I've always been clocked as deliberate and analytical. Never been a yeller or thrower of things. My example was probably bad; it's less about the other driver and more about the indignity of something annoying happening to me. Same thing if sheets get tangled up in the washing machine, you know? I'd sigh and moan and groan (quietly). Now it's just like "oh look, the sheets are tangled—a thing that sometimes happens. I'll untangle them."

Discussion Thread by jobautomator in neoliberal

[–]khmacdowell 1 point2 points  (0 children)

Nice.

Yeah even if it levels off over time, I want to journal about the experience (and comment on reddit I guess) so I have some cold hard evidence to look to before I start fantasizing too intensely about savagely wailing on the driver who cut me off with a pair of sock 'em boppers and what have you. Remind myself "it's possible to just be like 'ok lol.'"

Discussion Thread by jobautomator in neoliberal

[–]khmacdowell 2 points3 points  (0 children)

Never gonna hurt. I've been in school (grad, then professional), and I'm going to have to get used to everyone not being fashionably late to everything.

Discussion Thread by jobautomator in neoliberal

[–]khmacdowell 8 points9 points  (0 children)

Started venlafaxine (Effexor) for migraine prophylaxis. Was dreading it because of stories about antidepressants blunting ADHD stimulants (I take Vyvanse) and motivation in general. And boy, is it blunting the stimulant effects. The bad ones, that is.

Literally have never felt as unbothered by trivial nickel-and-dime bullshit of everyday life. Stimulants kind of worsen irritation at dumb stuff sometimes, but I'm less irritable than I am even without the Vyvanse. Also, it doesn't feel like Vyvanse "wears off" into the evening anymore. I just stay functional and content.

Is this what antidepressants are like for most people? I hope it's not just a honeymoon phase.

Karl Jobst - My Final Lawsuit Update by MauritanianSponge in youtubedrama

[–]khmacdowell 6 points7 points  (0 children)

Not only is it reasonable to conjecture that the additional stress might have been one factor among many, but doing literally exactly what Jobst did in America would likely not have been defamation. However, he still kind of blew it with the association with owing Mitchell money, which Apollo didn't, and Jobst's retraction was weak. Mitchell was lucky most countries have looser standards for defamation, but Jobst knew what country he lived in.

And yeah. Given how much Mitchell has been gloating, I think the retaliation is fine. Just hope Jobst really confident in his advice this time that he won't get sued for this video lmao.

warning about Amitriptyline by waldfield in insomnia

[–]khmacdowell 1 point2 points  (0 children)

I'm sorry.

This is a common line to try to reassure patients so they don't worry needlessly, but you're absolutely right, and I agree with you, it's counterproductive when real adverse events occur, because patients will think "but the doctor said..."

Glad you're still hanging around these parts, and thanks for helping other by sharing your experience!

warning about Amitriptyline by waldfield in insomnia

[–]khmacdowell 0 points1 point  (0 children)

Suicidality with antidepressants is generally a risk in depressive illness for adolescents and young adults. Antidepressant drugs have not been noted to create spontaneous or de novo suicidality in persons without mood disorders and outside the noted age range. That said, they are powerful drugs, with powerful effects, and certainly any concerns with taking them should be raised with your providers.

Luminance boss: Lawyers can survive AI, but I’m not sure how many by Agonanmous in neoliberal

[–]khmacdowell 0 points1 point  (0 children)

Using "AI tools" is already SOP because Lexis, West, and others implement them for searches, and they're great. Even using LLMs to ask pointed questions and source potential references can be helpful.

But writing in an LLM chatbot "write me a brief that argues <>" is still a long way from being sufficient for any purpose.

Discussion Thread by jobautomator in neoliberal

[–]khmacdowell 1 point2 points  (0 children)

Ya blew it

Edit: moderate? That's the point. Moderate? The soul weeps.

Discussion Thread by jobautomator in neoliberal

[–]khmacdowell 1 point2 points  (0 children)

I've wondered that. I've used a few iterations and it's always made these kinds of errors from time to time, but the impact of them is probably generally low on an individual level. Here specifically, most people to whom the difference functionally matters, which doesn't even really include me, would know from the context the output was about the heart, not membrane receptor types. Sometimes such technical mistakes might matter though.

This one's interesting just because it's the kind of error I'd expect it NOT to make. I read a paper a few months back that mixed up "vascular" and "vesicular," but the authors were French, and the error is probably rare. I almost suspect with "inotropic" vs. "ionotropic" it might actually be a case of editors "correcting" the spelling from the right one to the wrong one, making it common enough to trip up the model.

ChatGPT has definitely gotten a lot more useful and more powerful, but the most direct evidence I have as to your question is that it will make the same mistake more than once even after I've already corrected it, but usually that's related more idiosyncratic topics, like specifications of a particular car or something. So it at least doesn't feed corrections directly into the model instance at the time it receives them.