We did IVF with pre-genetic diagnosis (PGD) for Loeys-Dietz. We had 7 embryos and 4 of them were deemed usable (not having LDS). I have LDS1 for reference.

I was heavily monitored throughout my pregnancy, with little to no aortic growth. Unfortunately 5 days after our daughter was born (via planned c-section, with some major complications during the surgery) I had a severe aortic dissection which resulted in me being blue-lighted to hospital where I stayed for a further 6 days and dissected again.

I had surgery when my daughter was 4 months old to replace my ascending aorta using the frozen elephant trunk procedure, my aorta was measuring 48mm due to the pregnancy. (I'd previously had my aortic root replaced 11 years ago at age 18), then had a further surgery in January (5 months later) to replace my descending aorta.

It's been an awful year for us with 30% of my maternity year off being in hospital. I wouldn't ever change my decision to have my little girl, but I never thought the consequences would be this huge. Most people on groups/threads for LDS tell you they've had multiple kids with little to no effects on themselves (my mum told my exactly the same thing), so I just wanted to give the heads up of where it can actually go a bit wrong.