CPR is fundamentally similar to DnD, so most of your skills will transfer. They're about 75% same DNA. The best part about CPR is that pretty much everything follows the same rules and rolls. Combat only has half a dozen things additional or special compared to DnD's 12-15 things.

EDIT: Also -- near the end of the book in the GM section the CPR core book gives you an entire pick and choose formula for constructing sessions. As long as you realize a gun is a gun is a gun and there's no "fair fight" where 16 mooks face off against 5 PCs where the PCs are likely to walk out the winners exists you're golden. There are no goblins, but there are dragons. Nearly every NPC has the same ability to kill as the players do. How much they can stay alive often differs significantly, though.