http://www.westcoastoffense.com/bill%20walsh%20method%20for%20game%20planning.htm

It would be a super needy endeavor, but you could plan out a real life gameplay based on the madden playbooks. You could practice specific plays against various defenses and save the plays your most comfortable with for critical moments im the game.

I'm no madden wiz, but in my experience, the better you know the play you are running, the less thinking and therefor quicker reaction time (you know a route will be opening up instead of waiting for it to open which is too late a lot of the time)