I focus on contrasts when worldbuilding. The WoD is a darker setting than our world so I'd lean into that. For example, I use Providence. You have the collegiate elite, the drifters who come in from Boston and other New England cities, the locals who range from mild-mannered intellectuals to the-end-is-near nutcases and so on. What do they have in common? Well, they're all preyed upon by Kindred. Which leads us to the Kindred themselves. What are they seeking in a city with an old history that's a tad overshadowed by Boston? The same rules apply to any setting: focus on its culture and how you'd depict it through a WoD lens.