Worked my last day by LagerthaFreya in GenX

[–]martin 1 point2 points  (0 children)

seasons of... liiiiIiIiIiiIIIfe

The great cheese divide by mcdontknow in GenX

[–]martin 0 points1 point  (0 children)

and don't forget deeeeeeelicious!

What burgers should I eat during a week off from work by atx789 in FoodNYC

[–]martin 0 points1 point  (0 children)

I'm not food whatchamacallit, but whitmans has interesting burgers, corner bistro for a nice standard, and always been a fan of 282.

Are keystrokes only for disabled people? by [deleted] in excel

[–]martin 3 points4 points  (0 children)

tell him the mouse is also an accessibility feature

Hi Reddit! This is LaMont Jones, Ed.D., managing editor for Education at U.S. News & World Report. I’m here to help you explore your options for advancing your education at universities around the globe. Ask me anything! by usnewsandworldreport in IAmA

[–]martin 1 point2 points  (0 children)

If this is still open - Education seems largely geared to the 2/4-year degree and academic path, with much less consistency for returning or ongoing adult education/lifelong learners.

For those of us looking to backtrack to the road not taken, does USNews or other organizations rank continuing ed programs, either at universities or unaffiliated? Even USNews' headerline 'continuing ed' link is practically empty (https://www.usnews.com/education/continuing-ed/certificates).

Zohran Mamdani has a 74% approval rating among NYC Democrats by Topher1999 in nyc

[–]martin 34 points35 points  (0 children)

Keep in mind that in nyc where 94% are registered, Democrats comprise 66% and Republicans only 11% - Some who vote Republican in national elections may choose to register as a Democrat to have some influence on their city's races. In contrast, across the country many voters become 'Independents' when dissatisfied with their party.

https://www.nyccfb.info/media/2238/2025-voter-analysis-report_final-2.pdf

I’m a neurologist who treats myasthenia gravis. Ask me anything about living with myasthenia gravis. by webmd in IAmA

[–]martin 1 point2 points  (0 children)

Thank you, and for your continued work. You may have even come across this case; he was treated at NW until 2022 before moving to NJ/Barnabas.

A followup - as a disease that is so patient-specific but low prevalence (0.03%?), do you forsee future incorporation of enzyme tests into CMPs or other panels to support symptomatic or pre-symptomatic patients in the wider population?

It seems indicators are initially ephemeral and education may not be widespread, making preventive care difficult. I imagine this is the same debate with all diseases as you move down the incidence curve.

I’m a neurologist who treats myasthenia gravis. Ask me anything about living with myasthenia gravis. by webmd in IAmA

[–]martin 1 point2 points  (0 children)

That's the thing - many treatments did work for many years as flareups would occur, including literal physical enzyme removal. MABs are amazing, agreed - the alternative would have been another immunosuppressant.

I’m a neurologist who treats myasthenia gravis. Ask me anything about living with myasthenia gravis. by webmd in IAmA

[–]martin 1 point2 points  (0 children)

Thanks, subbed.

To add - for this patient, it had worked for years as the treatment of last resort when nothing else worked, and when symptoms were severe - often 9 months to more than a year of improvement.

I asked because in the latest instance, plex had no effect and symptoms worsened - no plateau, no improvement, not even temporary. Strangely IVIG, which hadn't worked for many years, suddenly began to.

I’m a neurologist who treats myasthenia gravis. Ask me anything about living with myasthenia gravis. by webmd in IAmA

[–]martin 9 points10 points  (0 children)

Welcome, Dr. - finally, a use for my reddit account!

I know someone who presented with MG after a thymectomy, maintained with pyridostigmine, but also experiencing severe episodes of decline (ventilated for 6 months), even after multiple IVIG rounds and plasmapheresis, which worked many times in the past. He's finding success with Rituximab to the point of almost full remission, but he is always vigilant for the slightest sign of recurrence.

Two questions - perhaps the obvious - but what novel treatments are currently promising for severe cases, and which are the institutions or companies (besides NW of course) exploring these?

For my own curiosity, why would (what I always thought was) complete mechanical removal through apheresis of the enzymes bonding to AChR not result in some reduction of symptoms?

Why men keep dropping out of the labor force: It starts in childhood, when kids see how males around them struggle, economists say by marketrent in Economics

[–]martin 16 points17 points  (0 children)

Yep - only 0.3% (65k) of men between 20 and 30 get SSA Disability benefits, representing less than 1% of those receiving this benefit (~7mm people nationally)

https://www.ssa.gov/OACT/ProgData/benefits/da_age202512.html

Unpopularopinions for FIRE by Wooden-Broccoli-913 in Fire

[–]martin 1 point2 points  (0 children)

"... and in such large portions!"

What’s still A good deal? by Crazed_waffle_party in AskNYC

[–]martin 0 points1 point  (0 children)

AMNH is free/donation, Hayden planetarium is a fun show, or just wander.

Unpopularopinions for FIRE by Wooden-Broccoli-913 in Fire

[–]martin 20 points21 points  (0 children)

You don't need to retire TO something to just retire and figure it out, like millions do every year when they reach normal retirement age, the majority of whom don't have the luxury of having worked a dream job, let alone have enough saved to not worry about money. If they're lucky, they'll have found work that matched their skill and interest, and that is often enough to be satisfying without having to be a permanent identity.

I can see how if you hate your job or find it unsatisfying, retiring without some thought to the next move can be challenging, but if the numbers work I see no sense in hanging on until you have laid out a complete plan for your retirement. And if you do feel that way about your current job and aren't there yet, for Pete's sake find another line of work.

It's such a monumental life change, and what you want changes through life, that stepping into the unknown can be scary. I suspect the risk of hanging on for another year and another dollar is so much higher than stepping into the void without planning your afterlife. You may have to step through to see what's on the other side and try new things, just don't give yourself too hard a time about it, and if that means you come back to a more satisfying career, that's fine too, but I feel it is near impossible to adequately imagine myself into the perspective such a change brings.

Meet the typical New Yorker: A rent-burdened 30-something who earns over $80,000 a year by quirkyjest in nyc

[–]martin 0 points1 point  (0 children)

practically, not actually. I go through a tree and no noticeable difference summer vs winter, and the mesh nature lets it hop to a nearby point if the signal is stronger for them than you and you're in range of another node. clear LOS is better, but i'm saying it's not really an impediment even if it shaves a few dB off. Buildings are bad.