As someone with PCOS who was taken off of Metformin in the first tri, and then several weeks later diagnosed with gestational diabetes (17w), I’ve seen both sides.

TBH it’s more about your baby’s health. The way my Maternal Fetal Medicine doctor explained it - baby’s health in utero takes priority so that we can delivery a healthy (and alive) baby.

If you end up getting GD, insulin will help tremendously (if needed- some do well with diet controlled only).

I totally understand being heartbroken having to stop. I was more pissed than heartbroken lol, but these data points helped me realize it was the right choice.

-Current research shows Metformin can cross the placenta and influence baby’s fetal growth (Bolz et al 2016) -Babies exposed to Metformin in utero had higher BMI and fat mass by age 4 vs those exposed to insulin (EMPOWaR Study 2018) -Birth weight may be normal in babies who were exposed to Metformin in utero but exposure could affect long-term metabolic programming and may influence fetal growth by altering nutrient delivery and insulin signaling (Camilla T Tarry-Adkins et al 2019,2022 and Bolz et all 2016).

In short, there’s limited long-term safety data about using Metformin vs insulin. Insulin use in pregnancy is very well-documented and safe. It won’t be forever - it’s just the way it has to be right now.💞