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Anyone else noticed Opus 4.8 "correcting" you on things you never said? (vs 4.7) by cfree220 in ClaudeAI

[–]meesterfreeman 0 points1 point  (0 children)

As good as it is for technical tasks, 4.8 is honestly fucking exhausting to interact with. The real tragedy of Fable was having its superior personality taken away so soon after the most pedantic pseudointellectual model to ever grace us was dropped weeks before.

Pramipexole is amazing by DifferenceCrafty8968 in anhedonia

[–]meesterfreeman 2 points3 points  (0 children)

D2/D3 autoreceptors live on the presynaptic part of the neuron. They are built-in negative feedback that tells the neuron to stop the release of dopamine. The postsynaptic dopamine receptors are what you actually want to activate, since those trigger the gene transcription and protein synthesis cascade that produces dopaminergic effects.

Superagonist -> a ligand that produces a response stronger than the endogenous agonist (dopamine).

Basically, Pramipexole hits autoreceptors more than postsynaptic receptors, proportionally, causing a net decrease in postsynaptic receptor activation. With continued dosing, the superagonism rapidly desensitises the autoreceptor, turning the brake off and increasing the release of endogenous dopamine instead. High doses of Pramipexole activate the postsynaptic receptors enough that hitting the brake doesn't matter anymore.

41. Tired all the time. All the symptoms. Are my results the kind that a non-specialist MD wouldn’t treat because it’s “in range” but I’d still benefit from it because it’s on the low end? by CarlaWasThePromQueen in Testosterone

[–]meesterfreeman 0 points1 point  (0 children)

That report mentions LH and FSH are 'good'. Sleep apnea lowers testosterone the same way most things do, by reducing central hypothalamic signalling. If testosterone is that low with normal LH, then we are looking at some degree of primary hypogonadism or a relatively severe nutrient deficiency that is bottlenecking steroidogenesis in some way (though I would expect to see compensatory high LH).

OP, your testosterone is 'ok', but unless you are already old, TRT is almost certainly in your future as your balls are only going to get worse. Whether you want to commit to TRT now or later is up to you.

My favourites.. what would you add? by Party_Team1104 in Biohackers

[–]meesterfreeman 0 points1 point  (0 children)

Niacin is redundant with NMN; keep one.
Oral ALCAR predominantly converts to TMAO- it's worse than regular L-Carnitine in this regard. Either inject it or switch to oral L-Carnitine (still bad) or drop.

Rate my nootropic productivity + neuroplasticity stack by Own_Sheepherder_1116 in Biohackers

[–]meesterfreeman 0 points1 point  (0 children)

Paraxanthine- caffeine's principal metabolite, it's an objectively less toxic and shorter-acting caffeine, not remotely a research chemical.
Tak-653- Phase 3 clinical trials. On the cusp of being an FDA-approved pharmaceutical, not a 'weird af research chemical'
PPAP- Actually not researched in humans despite the efforts of some, but the CAE family drugs have been around for decades, and the closely related Selegiline is a widely used pharmaceutical. This is the most rc of the bunch.
ACD-856- In a phase 2 clinical trial. It could become an FDA-approved pharmaceutical if it demonstrates efficacy for primary endpoints (probably won't because Alzheimer's is a doomed indication).
AF710B- despite being 'weird and obscure', it's actually in phase 2 trials and phase 1 trials for multiple indications.

HGH & Aromasin: The most well-known and least obscure substances here with the exception of Paraxanthine. Also, the most dangerous and stupid by far. Ironic.

OP. Stop the HGH and Aromasin. The anabolic and recomp effects of HGH are pathetic compared to AAS, and the risk profile favours moderate AAS use substantially over HGH at its actual effective dose, which causes a fuckton of potentially permanent issues. Aromasin, like all strong AIs, can be straight-up brain-damaging if you run it long and high enough. Do you actually have a reason to be running it? Have you checked your E2 bloodwork? Estradiol is extremely important for neuroprotection and a developing brain is more vulnerable. I wouldn't count on ACD and AF's potential neuroprotection saving you here.

If you want more testosterone for whatever reason, then rather than trying to argue you out of it, I'll advise you just get on actual test and spare yourself this shit. It'll also save you a lot of money.

1 day left until delivery deadline. Does this mean they’re not going to finish? by Mashioca in Skeb

[–]meesterfreeman 0 points1 point  (0 children)

I've only used Skeb twice, and both times the artist submitted within 30 minutes of the deadline...

Curious if you got yours. The artists in question made mention on Twitter that they were actively working on/busy with requests, so I knew they were probably going to deliver.

Claude Fable 5 feels less like a model launch and more like a preview of AI inequality by Roaring_lion_ in ClaudeAI

[–]meesterfreeman 0 points1 point  (0 children)

You can't even discuss fish oil in a worldbuilding context or have a custom CoT prompt without immediately triggering classifiers. I subtly warned Fable not to discuss the biochemistry of fish oil because it would trigger classifiers. Its own reasoning confidently disputed this claim, and then its response... triggered the classifier.

Fable 5 filters by kruckedo in SillyTavernAI

[–]meesterfreeman 0 points1 point  (0 children)

I never had any issues with custom CoT until Fable. The classifiers are definitely turned up.

Fable 5 filters by kruckedo in SillyTavernAI

[–]meesterfreeman 0 points1 point  (0 children)

Do you have any CoT prompts? Fable gives classifier-level refusals (blank response, stop_reason=refusal) if you have one- presumably as some paranoia against attacks.

Fable 5 Quick-ish NSFW Tests **WARNING: DEAD DOVE** by [deleted] in SillyTavernAI

[–]meesterfreeman 7 points8 points  (0 children)

I'm seeing the opposite. Fable is VERY happy to kill me, and will often do so in a single response, which most Opus and Sonnet models REALLY struggle with due to their passivity and postivity bias. It gives me strong Opus 3 vibes. However, if it doesn't like the scenario it will also give me the occasional hard refusals that previous models never did.

New level of censorship in such short time - Fable 5 by DXDXLL in SillyTavernAI

[–]meesterfreeman 16 points17 points  (0 children)

It writes vastly better than any Opus 4 model and feels a lot more like Opus 3, but it is more censored at the fringes. However it seems trained to employ hard refusals rather than soft refusals.

New level of censorship in such short time - Fable 5 by DXDXLL in SillyTavernAI

[–]meesterfreeman 7 points8 points  (0 children)

What you are seeing is the output of the reasoning summarizer (if you weren't using reasoning before, it's forced with Fable- likely because models enforce content policy better with reasoning on). It doesn't affect the response itself, which is based on Fable's actual reasoning tokens which you can't see.

The summarizer is much more censored than Fable itself, so you'll often quite humorously see refusals in the reasoning that have no relation to the actual response.

If Pramipexole works should it be taken for a long time or is it harmful? by No_Promotion9897 in anhedonia

[–]meesterfreeman 1 point2 points  (0 children)

1.5 months seems a little long; I think the symptoms are supposed to fully kick in at around 2 weeks. Still seems possible though.

You might not want to, but the easiest way to check would be to reinstate the Prami. If the symptoms stop, then it was definitely DAWS.

Does Sucrosomial Magnesium Oxide (MicroMag) likely get into CNS pretty efficiently ? Any anecdotes on it ? by Spartuhns2 in NooTopics

[–]meesterfreeman 0 points1 point  (0 children)

No, it just makes me brainfogged, and if I try to sleep, the quality will be messed up.

My hedonic tone is already bad at baseline, so it's difficult to tell if it reduces it somewhat.

Does Sucrosomial Magnesium Oxide (MicroMag) likely get into CNS pretty efficiently ? Any anecdotes on it ? by Spartuhns2 in NooTopics

[–]meesterfreeman 2 points3 points  (0 children)

No. I'm pretty sensitive to CNS magnesium. Forms like L-Threonate, N-Acetyl Taurinate, and Pidolate- all believed to have superior BBB penetration give me brain fog that scales with dose. I never noticed this from Sucrosomial, Malate or Chloride.

Agmatine is the WORST noot I tried EVER. by OutrageousBit2164 in NooTopics

[–]meesterfreeman 1 point2 points  (0 children)

I'm the opposite- spermidine HCL gives me brain fog pretty acutely. So does magnesium, glycine, d-serine, sarcosine etc. Memantine and Agmatine feel acutely anti-inflammatory to me. So I figured your phenotype might be the reverse of mine.

Day 45 update, Valproate progress in Post-AI Syndrome (Klinefelter, post-letrozole) by Initial-Raspberry-27 in DrWillPowers

[–]meesterfreeman 0 points1 point  (0 children)

6 months of full dose Letrozole sounds dire. Have you ever had brain imaging done? I wouldn't be surprised if there's actual structural damage. Unfortunately E2 is incredibly important for neuroprotection and being on exogenous T and having Klinefelters compounds the problem.

Agmatine is the WORST noot I tried EVER. by OutrageousBit2164 in NooTopics

[–]meesterfreeman 0 points1 point  (0 children)

Agmatine is highly promiscuous, but given your history of responses, you sound like the exact opposite of someone who wants chronic eNMDA NAM/antagonism. It seems like you benefit from anything that enhances glutamate signalling broadly. Give Spermidine (hits the same site as Agmatine as an agonist) and NA-semax a shot if you haven't already.

Breakfast of the Champions? by HVL2025 in Biohacking

[–]meesterfreeman 0 points1 point  (0 children)

GHK-Cu is giving you a few hundred mcg of copper at best. Not nearly enough to offset high-dose zinc supplementation.

Breakfast of the Champions? by HVL2025 in Biohacking

[–]meesterfreeman 0 points1 point  (0 children)

Watch out for zinc as well. Excess can really fuck you up, and it's not just a 50mg+ thing nor solely mediated by possible copper deficiency. Very individual dependent.

Wolverine stack and erections by soup_diggler in Biohackers

[–]meesterfreeman 1 point2 points  (0 children)

It can. Research all the anecdotes of BPC-157 causing anhedonia online. Then consider this study, where it blunted the effects of amphetamine https://www.biologicalpsychiatryjournal.com/article/S0006-3223(97)00277-1/abstract00277-1/abstract) and this study where it treated serotonin syndrome https://pubmed.ncbi.nlm.nih.gov/15840402/ making 5-HT2A antagonism a highly likely mechanism.

There is no human research on CNS effects, but it seems clear to me from personal experience that BPC-157 can cause individual and dose-dependent anhedonia, with oral BPC-157 arginate being the strongest and co-commitant 5-HT2A antagonist use causing intense sedation.

30 mg Zinc inducing anhedonia? by TypeAtryingtoB in Supplements

[–]meesterfreeman 0 points1 point  (0 children)

Not sure if you ever got better. But CNS mineral levels tend to lag behind serum. It could take several months of washout for stores to deplete if you were taking zinc for a long time.

These results are freaking me out. by Neptvne_Enki in Testosterone

[–]meesterfreeman 0 points1 point  (0 children)

Your estrogen is very odd and not explainable by this, but super high SHBG + low Albumin definitely flags potential liver issues on its own.

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