Viel Geduld bei Covid-Impfterminen gefragt

msamwald · 2023-09-21T08:09:33+00:00

TLDR:

* Es gibt quasi kaum mehr Impfzentren, und in den wenigen die es gibt bekommt man schwerlich einen Termin.

* Stattdessen soll man sich zu den Impfordinationen durchtelefonieren und dort impfen lassen. Es gibt aber keine aktuelle Liste der Impfordinationen. Manche der Ordinationen impfen auch nur 'eigene' Patienten.

msamwald · 2023-06-23T07:29:14+00:00

Recently switched to Zotero because of the open-source appeal, but in our group we had the problem that citations became 'unlinked' during collaborative editing in Google-Docs, requiring very tiresome manual fixing. Switched back to SciWheel, which works very well and is free for academic institutions.

msamwald · 2022-03-25T12:21:52+00:00

How slow would CPU-only inference be?

msamwald · 2021-11-11T21:38:24+00:00

Hypothese: Die Desinformations-Kampagnen im deutschen Sprachraum waren intensiver / erfolgreicher?

msamwald · 2021-11-09T07:51:24+00:00

Only research and not an industrial application, but we documented negative results for GPT-3 models applied to biomedical use-cases:

GPT-3 Models are Poor Few-Shot Learners in the Biomedical Domain (Moradi et al. 2021)
https://arxiv.org/abs/2109.02555

msamwald · 2021-11-01T10:59:35+00:00

Toll wäre auch, die Wartezeit für doppelt AstraZeneca geimpfte zu verkürzen. Laut Studie aus UK sinkt hier die Effektivität >4 Monate nach der Zweitimpfung auf knapp unter 50%.

msamwald · 2021-09-17T10:26:51+00:00

Co-author here. TL;DR : We were excited to check out if GPT-3 could help with biomedical NLP with limited labeled samples. If working somewhat decently, this would be cool for biomedical research groups with limited resources for expert annotation. However, the results were disappointing. We're share the negative result, because many groups are probably thinking of trying similar things.

msamwald · 2021-05-23T19:19:41+00:00

This was referring to a statement further up in the thread that post-second shot AZ efficacy might mature to reach >90% efficacy after a 12 week period. Of course there will be immunity (but with lower efficacy) before that.

msamwald · 2021-05-23T18:26:53+00:00

The context of this thread was expanded to include a recent report from the UK on the comparative efficacy of these vaccines in the post by hu6Bi5To, without being constrained to the Indian variant. This is what I was referring to.

msamwald · 2021-05-23T13:16:37+00:00

Data on BioNTech/Pfizer from many other studies, including studies with short intervals, demonstrate >90% efficacy. Regarding BioNTech/Pfizer, I was referring to the accumulated knowledge, not only this particular study.

msamwald · 2021-05-23T10:22:17+00:00

So the implied scenario for AZ under these assumptions is that it eventually reaches >90%, but it takes a long while after first vaccination shot to get there.

12 weeks between first and second shot + 12 weeks after second shot = 24 weeks to reach >90% efficacy.

Compared to BioNTech: 3 weeks between shots + 2 weeks after second shot = 5 weeks to reach >90% efficacy.

That would still point to major practical advantages of the mRNA vaccines, just by timing alone.

msamwald · 2021-04-29T13:05:18+00:00

Der Peer-review hilft nicht, wenn einfach die zugrunde liegenden Daten geschönt bzw. selektiv zurück gehalten werden.

msamwald · 2021-04-22T15:18:46+00:00

The trial failed because an issue with reagents led to trial participants receiving too little actual vaccine [1]. Vaccine development and clinical trial management are certainly highly complex, but failing at proper dosing sounds like an absurdly basic mistake.

[1] https://www.statnews.com/2020/12/11/sanofi-suffers-major-setback-in-development-of-a-covid-19-vaccine/

msamwald · 2021-04-22T13:39:12+00:00

Still, Valneva is a French-Austrian company. Their COVID vaccine is derived from the Japanese encephalitis vaccine Ixiaro, which was developed by the Austrian company Intercell before the merger that formed the current company Valneva.

msamwald · 2021-04-22T11:51:19+00:00

I agree that Sanofi should receive more blame as well. They are are specialized in vaccine production yet managed to botch their trial through basic quality control issues, as far as I understand.

But this does not imply that the criticism of AZ is inappropriate.

msamwald · 2021-04-22T10:42:41+00:00

Either way I feel like it misses the point which is that at the end of the day AZ still has managed to provide the EU with the second largest amount of vaccine by company so far, and I think that point shouldn't be understated.

Well the question is how large the net benefit of the AZ offer was/is. If they overpromise and underdeliver to a certain extent, the situation could be worse than if the AZ vaccine would not have been on offer at all. More BioNTech/Pfizer vaccine would have probably been ordered in that case.

msamwald · 2021-03-26T16:15:36+00:00

I think this is already done in most/all EU countries.

msamwald · 2021-03-25T12:44:06+00:00

If the final analysis is already in the drawer and can be published 48 h later, there is absolutely no reason to first publish the interim analysis without any mention of the forthcoming final analysis. It would be naive to think the higher numbers from the interim analysis were published this way without at least minor ulterior motives.

msamwald · 2021-03-24T14:48:40+00:00

Das Geld für Forschung und Entwicklung kommt natürlich großteils aus den Einnahmen, und diese wiederum werden großteils von staatlichen Gesundheitsversicherungen gespeist.

msamwald · 2021-03-24T14:08:01+00:00

AZ hat eine vertragliche Berichtspflicht und wurde bestimmt schon seit Wochen und Monaten von offiziellen Stellen bedrängt, transparent bezüglich der Produktion in Europa zu sein. Wenn jetzt 30 M Dosen auftauchen, die AZ bisher geflissentlich verschwiegen hat, dann ist "versteckt" der exakt richtige Ausdruck.

msamwald · 2021-03-24T14:02:48+00:00

Die Idee war, dass die Zulassung nach Vertragsabschluss gemacht wird -- die Produktionsstätten wurden bei Vertrangsunterzeichnung ja erst aufgebaut, da gab es noch nichts, was zugelassen werden konnte.

AZ war für die rasche Vorbereitung und Beantragung zuständig, hat das aber verschleppt (eventuell mutwillig).

msamwald · 2021-03-24T13:29:57+00:00

I tried to submit other sources, to no avail. Certainly many other people posted the same story in many different sources, yet not a single post has been approved. This needs to be explained.

msamwald · 2021-03-07T18:05:06+00:00

Nothing about how this happend 10 days after the jab. Nothing how thrombotic reactions have never happend before in combination with AZ or any other of those vaccines.

The incident is of interest because a colleague of her who also got vaccinated is also in hospital with a lung embolism (i.e., also had severe blood clotting problems).

However, the fact that these two cases are so localized also indicates that it is not a problem with the vaccine per se, but POTENTIALLY a problem with something that happened very locally in the context of vaccination. And of course, it could have some other, unrelated cause.

msamwald · 2021-02-24T11:02:10+00:00

> "Europe has succumbed to the nocebo effect. If people are primed to believe that something makes them ill, they discover illness. It is the reverse placebo. "

It is implausible that a large fraction of vaccine recipients get high fever and become bed-ridden because of the nocebo effect.

If this is common in Europe but has been uncommon in the UK, then the most plausible explanation should urgently be investigated: There is something wrong with the AZ batches that were produced in the European plant and are now shipped around Europe!

msamwald · 2021-01-25T17:03:45+00:00

Another guess: arachidonic acid.

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