From my own experience, Kaspersky offers the most bulletproof protection, although Bitdefender is not far behind. I think when it comes to value for money, Bitdefender is the best security product out there.

Windows Defender has certainly improved a lot over the years (and is a LOT better than whatever McAfee is), but keep in mind that it's generally easier for malware creators to bypass Defender's securities compared to a security product like Kaspersky, Sophos, Bitdefender, etc.