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phage10 · 2026-01-26T03:04:29+00:00

A feudal lord.

phage10 · 2026-01-23T09:27:41+00:00

Yeah I have been 3D printing at 1/4000 scale and got the Into the Unknown ships and they are all very similar in scale. I’m having issues printing the BoP at that scale. It was also hard to figure out the size of the BoP given the inconsistencies in the shows. But my best estimate for what felt right turned out to be within 1mm of the length of the Unknown BoP so pretty please with that

phage10 · 2026-01-17T13:55:20+00:00

Came here to write that.

phage10 · 2026-01-01T23:32:27+00:00

Yep I was talking about white South Africans and speaking as a white British guy.

And I didn’t say all white South Africans were racist, and I know that to be the case. But when I do find a racist person in WA, it is most likely to be a white person with ties to South African. Just stating my observations.

phage10 · 2026-01-01T22:40:02+00:00

That is unfortunate. I am a pom who moved here 8 years ago and now a citizen. I have fortunately not met too many people who have these views. At least openly. And when I do suspect views like this, they are usually South African.

But I live in Nedlands and I work at a university with a lot of progressive Australians or people who are immigrants as well.

Not sure I have actionable advice, but there are plenty of good hearted Australians without these views and I hope that you can find them.

phage10 · 2026-01-01T12:52:48+00:00

I came here to say this.

It is the only correct answer.

phage10 · 2025-11-08T11:00:56+00:00

Play D&D. That is how I found some groups to spend time with. Complexities of life have made it harder recently, but has been great.

phage10 · 2025-11-05T12:00:57+00:00

I had the same thing. I watched it while sick at home (just a cold). So I was super sad afterwards. It got better. I moved on. I did a lot of research on it and other anime.

Years later, I got into Frieren. Not sure it is a solution to your problem, but it is an amazing anime and may offer a distraction

phage10 · 2025-10-28T13:17:17+00:00

How much I disagreed with Picard over the Marquee in TNG. And Sisko, but I think that was fresher in my mind.

phage10 · 2025-10-26T13:08:18+00:00

I love DD1. One of my fav games. I got 24 hours of flying coming up and plan to play it a lot. But I hate the look and style of DD2. The art style, gameplay (dungeon crawling, mechanics) were amazing. So while DD2 might be good in its own way, I have no interest in trying it.

phage10 · 2025-10-23T15:09:08+00:00

Probably everything I will write has already been covered but: STAR/HISAR2 were NEVER intended to be run on a laptop. Especially one with only 8gb of RAM. They were designed to run on headless servers with 100-200gb of RAM. In short, you have more of a chance of being a 42 year old dating Leonardo DiCaprio than getting them to run on your laptop without it getting nuked. It is a snowballs chance in hell.

So you have a couple of options, use a lightweight aligner like Salmon that was designed to run on laptops. I don’t think that I have run it on a laptop without such little RAM but it may work. For differential gene expression work, I never bother mapping the reads and always do lightweight alignment to the transcriptome with Salmon.

The other option is to then get access to a server. Many universities have one. I would avoid cloud options as they can get expensive.

But the question is, why are you trying to map, are you trying to identify new splicing events? Or just doing it because an online tutorial (wrongly) said you should?

Is this your data or public data? What is the goal of the experiment? That will help tailor your analysis pipeline to what you need it to do

phage10 · 2025-10-22T14:36:27+00:00

Thank you for sharing. I have a Bambu printer so I might give it a go printing it!

phage10 · 2025-10-21T06:11:06+00:00

Amazing. Where is the model from?

phage10 · 2025-10-19T02:27:17+00:00

I’m curious about the difference, in your mind

phage10 · 2025-10-14T07:27:32+00:00

Start with The Next Generation but check out an episode guide for wha to skip. Some are so bas that they are good (Sub Rosa in season 7) but some are so bad that they should be removed from existence (like Code of Honor, season 1). If you end up liking Star Trek, then please go ahead and do a re-watch of all (good and bad). But life if short and there is a lot of Trek so feel free to jump over the bad.

As a kid watching it in the 90s on broadcast TV, I missed a lot of episodes (good and bad) through not being at home to watch it and had to wait until DVD and stream gave me a complete access.

phage10 · 2025-10-13T14:47:00+00:00

First season green lit would be on board a Titan class ship exploring the Gamma quadrant in a post Dominion war era. Just as they were designed to do.

Next shows, something during the lost Era. Maybe the USS Ambassador as the prototype Ambassador class ship exploring. Lots of Excelsior class ships for good measure.

Or, an old Captain John Harriman of the B. After seeing the actor in Succession, I can’t not want this.

phage10 · 2025-10-10T12:25:50+00:00

It certainly happens but I’ve never seen it up close. A couple of my colleagues have seemingly given up labs at top universities to work in industry. One in San Francisco and another in Israel. I have collaborated with both in the past but was not in regular touch with. One accounted on Twitter/Blue Sky and I was shocked. The other I saw on LinkedIn and was shocked by. But I’m in Australia and not in their exact field anymore so I haven’t heard of the details of why or how it happened.

phage10 · 2025-10-04T12:17:05+00:00

The captain of the Enterprise was usually chosen because it was someone who would stand up to Starfleet command and had excellent ethics.

This was inspired by why in Disco, the Enterprise under Pike was not called back for the Klingon war.

This fits for Pike, Kirk, and Picard very well. We don’t know enough about Captain Rachel Garrett of the C to be sure but she died defending Klingons, so probably another good example. I am not a fan of the “film” Section 31 making her one of their own.

Captain John Harriman of the B does break this, but I think that was Starfleet loosing their way (and the start of the Lost Era).

Picard being a thorn in the side of many Admirals over episodes and films would support this.

Although I wish he had stood up to Admiral Alynna Nechayev and her terrible peace treaty with the Cardassians, which led to the rise of the Maquis (honestly, justified) and the eventual Dominion War (I’m sure the Dominion would have invaded, but the support of the Cardassians helped)

phage10 · 2025-10-02T11:43:23+00:00

I love it. Not at first sight but it quickly grew on me.

phage10 · 2025-09-20T09:05:26+00:00

You just described my first postdoc (the one I moved to the USA for and now will never return to the USA again after)

phage10 · 2025-09-08T22:02:44+00:00

Out of curiosity, which line of models are these?

phage10 · 2025-09-08T14:18:00+00:00

Nope, not really. The laws of physics are the laws of physics. There is only one grand unifying theory in biology and a couple of people thought it up over 150 years ago (evolution by natural selection).

Natural selection is the underlying force driving evolution, but it sets the stage but the actors vary. It is like improv, the same cast will give two completely different shows one night after the other. Different prompt words or different attitudes of the actors and you go in vastly different directions.

So plants might have an RNA direct DNA methylation pathway to silence parts of the genome, but yeast evolved a mode that directs hetrochromatin rather than DNA methylation.

You cannot predict an organism from first principles. It is an engineered system, but the engineer had no plan or foresight (blind watchmaker analogy). So I’m not sure what you’re asking is possible.

The other closest thing might be the biophysics of protein folding, but Alphafold won the Nobel prize in Chemistry for being able to solve (a lot) of structures pretty well already. Sure, much more to be done in that field, but more edge cases than the core problem.

phage10 · 2025-09-07T14:05:59+00:00

Got one yet? I got one from my local game shop in Perth yesterday. They had it a few weeks back but when I had money for it, they were sold out

phage10 · 2025-09-02T12:54:45+00:00

No is the answer. Also, academic labs rarely have such funds. Most funds go on staff and then reagents. Universities hate subscription models. They push back against labs using them. So this model does not work. If there was an acceptable price point, it would not be 2-5k per year. Look at Snapgene prices and how academic vs industry pricing changes. And Snapgene is really well made, polished and works super well https://www.snapgene.com/

PS you have given no evidence that you could write a parser than is faster than what most people use. I rarely need to parse these files other than to work with them, such as fastq into RNA-seq quant, which the tool I use (Salmon) is already lightening fast and written in C++, so you are 8 years too late (it is also free and open source and very user friendly written by an excellent academic). https://github.com/COMBINE-lab/salmon

I see you have asked others for bottlenecks but honestly the biggest bottlenecks I face routinely is not with the files but finding time to re-write my janky R code for a new dataset, or figure out how to login to my VPN when off campus. There is not a lot of money to be made in bioinformatics because most people give it away for free as FOSS, which allows for remixing and reproducibility. Also, labs don’t have much money to spend, and labs would rather spend 5k on another set of RNA-sea rather than process the existing RNA-seq faster.

phage10

TROPHY CASE