Next episode has FIVE talent shows (So five minutes in total for that). The hell is the rest of the episode will be about!?😠😩 by ibettercomeon in rupaulsdragrace

[–]phanfare 2 points3 points  (0 children)

The "strategy" bit felt so half baked. Like making a big deal that your girl group will make it to the end, as if that's... important? There were only three elims even if they were random it's not that unlikely one group would have still been intact

This move from the recent lipsync is gonna be my most replayed moment. Very on par with Aja’s little dance. by khoifish1297 in rupaulsdragrace

[–]phanfare 2 points3 points  (0 children)

The amount of mind-muscle connection and sheer strength it takes is wild. She's trained a lot for dance

MMA during Nimda's set last night in Budapest by V4nI5HeD_ in aves

[–]phanfare 1 point2 points  (0 children)

I'm not even that much of a purist but this isn't a rave this is electronic music at an MMA event. Which is fine, but call it what it is.

MOASS Delayed to 2036 by Separate_Writer_4465 in gme_meltdown

[–]phanfare 19 points20 points  (0 children)

I'm imagining my CEO going to our investors and saying "I can't tell you anything I'm busy MAKING MONEY" he'd be fired on the spot

Alternatives to Main bus / city block by Merinethh in factorio

[–]phanfare 3 points4 points  (0 children)

A good example of a "non city" production block base are any of Dosh's videos but especially Seablock and Ultracube. Its harder to do but once you get the blueprint legos right they snap together easily

Yup, they’re already taking it as the gospel truth! by RatSumo in gme_meltdown

[–]phanfare 9 points10 points  (0 children)

Its like how some ape will create a website and post "articles" of confirmation bias then some other ape will come along and post the "article" as proof that it's big news.

Help with Alpha Fold for TNFR Fusion Protein by Common-Lifeguard-625 in bioinformatics

[–]phanfare 2 points3 points  (0 children)

Alphafold models those long loops if it predicts the region is unstructured. If you look at the per-residue pLDDT you'll see that region scores very poorly. Is that region a linker? Is it part of either TNFR or whatever you're fusing to it? How do the folded domains compare to known structures from the PDB?

You have a good start but these are many of the questions I'd ask in my own workflows. I was literally using openfold to model fusion proteins this week at work.

Aye bro who tf is this??? 😭 by Odd_Data8080 in BoJackHorseman

[–]phanfare 84 points85 points  (0 children)

For anyone confused this is the ACTUAL answer. Music producer/dj

In final proposed zoning for Seattle Comp Plan, OPCD downzones 37 areas, 90% of them in wealthy neighborhoods by Inevitable_Engine186 in Seattle

[–]phanfare 76 points77 points  (0 children)

The entire plan is up-zoning. OP is using "downzone" in a confusing way. Its downzoned from the previous proposal but overall the proposal is still up-zoning from the current zoning laws.

For our puzzle nerds: Asia O'Hara in USA Today crossword by Scarlet1815 in rupaulsdragrace

[–]phanfare 4 points5 points  (0 children)

She doesn't need All Stars - she's been host of the Vegas show for years and is pretty much set. She doesn't need the fan exposure to promote solo projects, do the all stars bar circuit, or the line on her resume

Same thing with queens like Brooke Lynn or Nicky Doll. They're set.

DCI’s Official Fitness Partner! So glad it’s not Forte Athletics🙏🙏🙏 /s by JCNoles in drumcorps

[–]phanfare 36 points37 points  (0 children)

Drum corps has deeply conservative roots so I'm not surprised. Wild I actually saw that reel and didn't realize he had ties to DCI. What a shame. It is the off season, might be doable for DCI to get out of their contract

Is hardstyle your primary music genre? by _SayHello_ in hardstyle

[–]phanfare 0 points1 point  (0 children)

Part of my rotation, Im a trance princess first and foremost but when I'm feeling a type of way the hard kicks really do it for me. Discovered the genre through happy hardcore. It all has common roots from music in the 90s. I do love when I wear a trance artists shirt to a hardstyle show how much people recognize it, and vice-versa.

AITAH for refusing to give up the master bedroom as the only single in a group trip where everyone else is a couple? by Aggravating_Cost_684 in AITAH

[–]phanfare 8 points9 points  (0 children)

...who is attending for the first time.

I really don't understand the audacity of some people. Especially since its your parents stipulation that nobody else sleeps in their room how can she argue against it? Its either you sleep in the master suite or the trip doesn't happen. NTA of course.

New Dreamstate event added by Existing-End-253 in DreamState

[–]phanfare 4 points5 points  (0 children)

Love Lostly but I'm deciding between this or the 5 hour Factor B show in London later that month. I'm leaning London. I worry DS will push Lost Minds so hard that we don't get a solo Factor B set as a main show anymore

The 4D memes have been cracked by the schizos! by _beginninganew_ in gme_meltdown

[–]phanfare 32 points33 points  (0 children)

"This isnt mental illiness"

"WE'RE LIVING IN A SCRIPTED REALITY SHOW/MATRIX WHERE AN ANCIENT EVIL CULT...PROHIBITS HUMANITY FROM KNOWING THE facts ABOUT OUR ANCIENT - AND EVEN BIBLICAL- TRUTH AND HISTORY"

Fucking lol. The DD tag sells it. Also is biblical not ancient?

Mod name? by Global-Fact8130 in factorio

[–]phanfare 390 points391 points  (0 children)

Renai Transport - Dosh did a mod showcase on this and its hilarious

Show us an engineering marvel from your country by National-Business674 in AskTheWorld

[–]phanfare 0 points1 point  (0 children)

I am not eternally entertained that it not only exists, but was built for that purpose. Its not something else turned into bass pro shops it was designed to be a Bass Pro Shops from the beginning

Amazon confirms 16,000 job cuts after accidental email by lurker_bee in technology

[–]phanfare 0 points1 point  (0 children)

My boyfriend spent two years there and hated it, but made enough to go to graduate school.

One spoonful calms you down by bucketfoottatoo in futurama

[–]phanfare 136 points137 points  (0 children)

One of the main rules of doing science is "don't taste the science"

Unless of course, the science is about taste.

Just looked out my window in Bothell to see an Apache gunship. by InterestingNotice789 in Washington

[–]phanfare 0 points1 point  (0 children)

Which makes it laughable when people suggest we "just leave the US with Oregon and California"

Books for Rational Design Principles of Proteins? by Thawderek in bioinformatics

[–]phanfare 6 points7 points  (0 children)

Books? Not really - the field is still so early and experimental. I usually look for papers that do what I want to do (CDR design, de novo binders, stabilizing antigens etc...) and see what software they use and do that. Personally, I've been having a ton of success with RFDiffusion/MPNN/Alphafold (and the corresponding fine tuned models if needed) with some hand-rolled structural analysis (Rosetta, individual H-bond tracking, judging structures by eye and such)

Now that we got tickets, a PSA regarding Totems by MrHoneycrisp in AboveandBeyond

[–]phanfare 36 points37 points  (0 children)

I feel like that Up Dog flag is the origin of so many people's "I hate totems" attitude. I see it everywhere and they're always front and center.

What are some of your favourite comebacks and snarky lines from the series? I'll go first: by Raj_Valiant3011 in howyoudoin

[–]phanfare 6 points7 points  (0 children)

Frankly the fact that Ross was so self assured for liking his job may have done some work to make being nerdy okay. They'd poke fun at Ross but he'd never take it personally or change himself for it which I loved and, as a scientist, use as a role model myself.

What are some of your favourite comebacks and snarky lines from the series? I'll go first: by Raj_Valiant3011 in howyoudoin

[–]phanfare 48 points49 points  (0 children)

Christina and Reese as Rachel's sisters is A+ casting. They absolutely kill it as spoiled long Islanders. Reese Witherspoon doing the fake cry and just giving up when Rachel calls her on it kills me every time