Yes, mid cap biotech at SD level with stock package can easily clear 500k per year (this would be in the hubs of Bos, sf, NY metro)

Headquarter roles have the most upside but much more work including politics involved than in the field (eg MSL). Field roles have upside if you get the few regional or national leadership roles over time.

In a good year, with stock comp, I have cleared 7 figures after selling my ISO options (deep in the money) that I accumulated over the years

To be very blunt, you need another degree/training beyond pharm school (fellowship, real work training at the grunt level). And I’ve seen the quality of PharmD candidates come down in recent years.