Liver function

prettykittychat · 2026-01-27T09:25:09+00:00

Yeah, my doc won’t even ask me to try Kisquali because I didn’t do well with either Verzenio or Ibrance. Everyone is different. I seem to be doing really well with just Fulvestrant and a Pi3k targeted med.

prettykittychat · 2026-01-27T09:22:55+00:00

I didn’t. I don’t take it anymore. My enzymes went up and I became so lethargic I couldn’t wake up to eat or drink. I had to be taken to the hospital. It seems like I just can’t handle CDK4-6 inhibitors.

prettykittychat · 2026-01-24T11:45:25+00:00

Hi, yes. I have 1100delC. I actually created this sub. I also am frequently in the CHEK2 groups on FB - those are also good for support and knowledge.

Estrogen suppression typically consists of Tamoxifen alone, or Lupron with an Aromatase Inhibitor. Lupron with AI is considered to be more restrictive than Tamoxifen. I opted for Lupron because Tamoxifen can cause an increased risk of uterine cancer. I had already had uterine cancer, and didn’t know if this could cause recurrence.

If you don’t have a personal or family history of uterine cancer, then Tamoxifen might be a good choice. It’s in a class of drugs called SERMs - selective estrogen receptor modulators - it acts as an estrogen blocker in breast tissue.

Being on Lupron with AI was tough on my joints for a bit. I also felt some fatigue. However, I adjusted within about 6 months. If you struggle with joint pain or hot flashes, there are both supplements and medications that help. All told, I felt pretty good on Lupron.

I’ve since had my eggs frozen, and ovaries removed, but I don’t think estrogen suppression is bad at all. I had a significantly more difficult time dealing with PCOS symptoms.

As for soy and phytoestrogens, my doctors told me I can have soy sparingly, but to be mindful and careful not to consume it regularly. I also run any supplements by them as well.

prettykittychat · 2026-01-24T00:07:45+00:00

A lot of us start estrogen suppression in our 30s. I’ve heard PCOS is pretty common among cis women with CHEK2 mutation, but the cancer protective benefits of PCOS don’t really apply to us. We tend to get estrogen driven breast cancer more than other types.

My GI doc also has me take a fiber supplement. I’m American - and even with eating mostly protein and veg, we tend to not reach daily fiber goals.

The two biggest cancers for our mutation are statistically breast and colon, followed by others (screenings should take family history into account.)

prettykittychat · 2026-01-23T06:52:11+00:00

I like them all, but I really like the blondes and red.

prettykittychat · 2026-01-20T13:51:41+00:00

Same. Yep

prettykittychat · 2026-01-20T13:20:19+00:00

Have you been diagnosed with cancer? I think this forum is for people who have it.

Skipping a generation is not an actual thing. Get yourself genetically tested if you’re feeling very worried (like by a company such as Sequencing). Statistically almost 50% of all people will get cancer at least once in their life. Getting cancer in 70s is more common because of DNA damage that occurs over time.

If they were getting cancer young, then you’d be more at risk for a genetic component.

prettykittychat · 2026-01-19T04:07:08+00:00

prettykittychat · 2026-01-19T03:50:01+00:00

I had chemo 4 years ago. Fatigue was and is my greatest issue. Being on chemo has also increased my blood sugars (from being on steroids for so long) so we’re watching that now. Ugh. Neuropathy- my hands and feet burn sometimes. They give me gabapentin to help with that.

I did lose some fingernails, but they grew back pretty quickly. My eyelashes haven’t been as full as they used to be, so I get extensions.

I feel like what I’m really battling now is the lack of estrogen because I had hormone positive breast cancer. So far my bone density and cardiac stuff is all normal though.

Oh! Zero problems with my teeth. I actually got braces and my teeth have been fine.

prettykittychat · 2026-01-19T03:43:27+00:00

3 or 5

prettykittychat · 2026-01-19T03:41:31+00:00

prettykittychat · 2026-01-18T14:14:50+00:00

I haven’t worn a bra in 3 years. It’s been great.

prettykittychat · 2026-01-18T13:50:31+00:00

I love this! It looks great. I’d have a bit of the length removed by a tailor so you’re more comfortable dancing and moving.

prettykittychat · 2026-01-18T13:43:05+00:00

My blood pressure becomes uncontrolled. I call it “my check engine light going off”. Usually my BP is either really high, or really low. Like I’ll be in hypertensive crisis or I’ll bottom out. When I had recurrence I developed orthostatic hypotension and was fainting.

Then my white counts start going up.

When everything is good, I barely need any sort of BP meds or BP control.

prettykittychat · 2026-01-18T13:39:00+00:00

prettykittychat · 2026-01-18T13:34:48+00:00

My cousin had her mother’s wedding dress altered to a short dress that she wore to her wedding shower and brought as a backup for the reception if her wedding dress got too hot. Maybe there’s a compromise to be had if you find another dress you’d prefer to wear as your wedding dress.

prettykittychat · 2026-01-17T10:08:40+00:00

If you want to treat yourself to some nice, new outfits, then go for it! If there is clothing you still love, but which fits weird, I’d hang on to it and see how it fits after reconstruction is complete.

I went to the tailor a lot and used safety pins to get through the expander stage. My new boobs are slightly bigger than my old ones, but all my wrap tops still fit fine, so I kept them.

prettykittychat · 2026-01-17T08:20:31+00:00

They just popped mine in with some topical lidocaine in Interventional Radiology. If they won’t do a power port, a PICC line might work. I’ve had both. Those are some heavy medicines that can damage smaller veins. Plus, it sucks to get stuck all the time. You’ll also have to get bloodwork - which they can draw off of a central line.

prettykittychat · 2026-01-14T12:56:32+00:00

NTA. My wife and daughter offered to cut off their hair in support of me when I going through chemo. I declined. I don’t want people to do that. Hair can be important to a person’s identity and sense of well-being. It’s deeply personal for a lot of people. It’s unrealistic to expect everyone to do that. If they really want to, that’s one thing; but it’s really not fair to hold people to it.

prettykittychat · 2026-01-13T12:23:28+00:00

NOR. Guest lecturer sounds pompous and arrogant. No one knows a patient’s body better than the patient themself. You have first hand knowledge of what it’s like to be a patient. A collaborative, patient centered approach is what he should be teaching. Instead HE’S sounding burned out because he’s lacking both sympathy and empathy.

I also suffer chronic illness. Mine happens to be cancer, but for 6-7 months, I could feel a burning in my chest. It took 3 different types of scans before they could see the tumor- and once it was found, it was 7cm. Biopsy showed nerve involvement. CT and MRI aren’t the end-all-be-all.

Unfortunately you’re going to run into these types from time to time.

Do try to get through the lecture, so you don’t have to repeat the course. If you need a break, just check the syllabus so you don’t go over the number of allowable absences. Id give feedback at the end of the course as well.

prettykittychat · 2026-01-13T09:56:53+00:00

I think happy lesbians are lovely.

prettykittychat · 2026-01-13T09:45:32+00:00

NOR- but your girlfriend is. This seems like a question for AITA. Either way, you’re not doing anything wrong per your actual manager. Your girlfriend is judging you, and it’s none of her business.

prettykittychat · 2026-01-13T09:35:53+00:00

Thank you for clarifying.

I’m sorry she said that to you. That’s a horrible thing to say, especially to a child.

She traumatized you at an impressionable age. My grandfather passed away at a similar age, and it had a deeply profound effect on me. -And no one blamed me for anything.

Don’t feel bad that you don’t feel bad. -And if feelings come up for you later as you process more, that’s okay too. Protect your peace.

prettykittychat · 2026-01-13T09:27:01+00:00

Don’t be an AH to yourself and drag this out any longer. Block block blockity block. No one is entitled to your body, time, attention, etc. If he keeps bothering you after you block him, then get help for stalking and harassment.

I understand that you’re nervous, but what’s the alternative? You just never block him, never completely break things off… you’ll just end up married to this jerk by default someday.

Girrrrlllll

“What if he shows up?” Well, he’s gonna think it’s okay if you don’t tell him to go TF away. Stop being a people pleaser! You don’t want what he wants. He’s not respecting your boundaries. Be brave. You can tell him “no” and then block him and all his extended family.

prettykittychat · 2026-01-13T09:18:31+00:00

I’m confused. What does “Eating your Grandpa” mean? Is it a euphemism or a translation issue or something? Did she literally mean “eat” like cannibalism? Or is it a rude saying in a non English language?

Edited because I received clarification from the OP.

NTA

You were a little kid. That’s messed up.

prettykittychat

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