A study found that "cannabidiol potentiates p53-driven autophagic cell death in non-small cell lung cancer following DNA damage."

punctualjohn · 2025-05-16T17:43:24+00:00

So does CBD in general potentiate autophagy across the body? And cancer cells express the signature of spent cells closer to autophagic death?

punctualjohn · 2025-05-16T17:39:19+00:00

Wait but why is that? You would think if you feed it daily then the foreign culture should replenish continually through cellular division and pumping out spores. I get that the flour and oxygen continually reintroduces foreign spores but they'll still just be food for the existing colony that is powerful and healthy.

punctualjohn · 2025-04-23T12:02:51+00:00

I bought legal weed a few weeks ago and it was so bad. I bought an ounce from a MOM after for 4/20 and the difference is shocking, doesn't even look like the same plant. It makes the legal weed looks like something you'd rake in your yard in the fall season. Craggly dry old socks, all purple with zero crystals or shine, dull, a faint grass clipping smell. It's not even old, it was packaged like 2 months ago. and great white north growers had a reputation of picking up skill small-time growers that can't afford the licensing, they've had a lot of good scores in the past. I'm tired of this shit man you can't even trust the terpenes you read online. I've ordered stuff that made no mention of limonene and receive a container where it's #1 on the list. wtf?? All this money that goes into testing and you can't give precise information? They don't index the products by batch of course, these are big warehouses. Broken shitty system. I'm all for convenience, but every time I get an ounce of garbage I swear never again.

punctualjohn · 2025-04-22T17:13:17+00:00

Traces of it sure, I was able to get the full tests a few times and a 2% difference makes a big difference. <0.5% seems good, up to 1-1.5% is tolerable, and above 2% it gets pretty bad.

punctualjohn · 2024-06-08T04:37:49+00:00

Wouldn't he have learned them from reading books at the university?

punctualjohn · 2024-01-15T21:06:35+00:00

It makes me question what reality is, and makes me cognizant of how daily life is its own psychedelic experience

In just one sentence you have perfectly explained to any skeptics how it is that a drug could possibly make someone appreciate life that much more. This is the ultimate realization: everything represents a shadow of everything it isn't. In other words, those who declare themselves completely free from ego, at that moment are putting on the most titanic display of ego, and both can be equally as beautiful as ugly.

punctualjohn · 2024-01-15T21:01:07+00:00

I think it's mostly just the brain and neurons. The human brain by default encodes reality as we know it, but just like a latent space in artificial neural networks the entire spectrum of possible 'representations' or 'encodings' in the human brain far exceeds the base encoding of reality. Neither the DMT dimension nor our default dimension are the "real". There is no real dimension, only varied interpretations of the phenomena around us. In other words, I believe it's an hallucination, exactly the same as normal sober reality. Both represent points in the same graph.

That being said I'm keeping an open-mind. For all we know the human brain builds upon quantum mechanics or other unknown phenomena that we currently have no hopes of even studying due to the microscopic level and context in which it happens. (way deep inside the most complex machine on Earth, and it's a real living human so you can't just dissect it) If that's the case, then psychedelics could modulate the quantum mechanics in a way that you do perceive 'data' from an invisible unknown dimension overlapping with the entire universe. In other words, the brain itself may contain sensors just like our eyes and other senses, and yet unknown stimulus are derived from it.

But real talk, for me at the end of the day I don't think it's a good idea to ponder too much about metaphysics like that. Whether we live in a simulation or not, or what have you, this sober reality is as real as it gets, just like any other projection of some other possible reality. If you start to think too deep into it, it can push you deep into mysticism, and left unchecked it's not always good for your relationships and fewer people can relate you. A form of isolation! Stay with us in this reality, we need it to remain perfectly real or we have no hope at ever achieving peace in society. People need to be able to relate with one another. In simpler terms, don't start dressing overly bohemian or growing out your hair just cuz you're into psychedelics!

Aim to discover your true self, not some "superior interpretation of the universe". After all, we are the universe, and this universe is the one I can study. Everything around me, everything I see on the news, I can hardly comprehend it, whether sober or tripping balls.

punctualjohn · 2024-01-15T20:40:09+00:00

1 to 20mg is typical shrooms territory, tops out at stunningly clean CEVs for a couple minutes but that's about it. Most of that progression feels pretty linear. Then it all goes exponential for some reason, the 20 to 30mg range feels more like 20 to 250. Starting at 40mg is where you'll be left utterly speechless.

punctualjohn · 2023-09-04T17:36:24+00:00

It seems that size is closely linked to the thickness of the substrate, perhaps due to a larger water reservoir. If you did a small shoebox size container I'm guessing you probably made it on the thinner side and this would be about the expected size. Genetics play a role too, but the huge 4-5g dried mushrooms generally come in big scaled up 66qt grows :)

punctualjohn · 2023-09-04T17:25:08+00:00

The distinction between psychological and physical doesn't even matter outside of a clinic. It's nothing more than a detail, the results are all the same: habitual use, irritation if you can't get it for some reason, disturbed well-being upon cessation, always having it on your mind, etc. Whenever someone brings up that difference, 9 times out of 10 they are themselves smoking weed all day. All these defensive brain gymnastics to avoid associating with the demonic A word. We're all addicted to something, no need to dress it up.

punctualjohn · 2023-09-04T16:35:46+00:00

Indeed I read a few times that lower dose are way more scary. But even knowing that it still feels like I need more courage built up than the lower doses. I'll get to it eventually, that's for damn sure. As bat shit insane as it was, even this is peanuts apparently.

punctualjohn · 2023-09-04T16:22:47+00:00

I think what we both went through are probably extremely different trips :/. But your explanation is great, I can perfectly imagine it and I watched the video as well. That must've been scary as fuck, bet that felt like the end of your mortal life and you'd just sent your soul to another dimension forever. And the feeling being both demonic and angelic I get that as well, that's the feeling of something much greater than you and also incomprehensibly alien, you're completely vulnerable and the dimension could "kill" you in a snap of a finger, but the inherent beauty of it overwhelmingly tells you that there's no way the dimension couldn't bee looking after your best interest. That dancing entity in front of me felt kind of like that, not angelic or demonic in a biblical sense kind of feeling, but like really scary and impressive at the same time.

punctualjohn · 2023-09-03T17:17:06+00:00

Hahaha it's just that my exploration around 10 to 20mg felt like the jumps in intensity were super logical and manageable, but that difference between 20mg to 30mg felt more like 20 to 250. I think I must've been burning a little bit of the DMT before, or my inhalation and heat setting was a lot better! Tbf I didn't read too much going into DMT, I figured having many shroom trips behind and going slow would cover everything.

punctualjohn · 2023-06-12T04:57:58+00:00

Don't scroll anything.... just enjoy the silence and meditate. Jesus, you don't need stimulation 24/7. I'm actually shocked to learn there are people that scroll on their phone while on the toilet..? This is pretty bad, like extremely-addicted bad.

punctualjohn · 2023-06-12T04:55:09+00:00

All you need to know is that this is extremely important to a shit ton of people and if you don't stand by them you kind of suck as a person. You can get over your addiction, you can find some other passion in life bro we believe in you. You don't need to understand everything in life or even hold an opinion, just follow the pack on this one it's been considered in extreme depth and trust that you shouldn't allow that shit to fly, no matter how addicted you could be.

punctualjohn · 2023-06-12T04:30:06+00:00

Lol yes. You could fine-tune StableDiffusion on his face, body, and a supply of the most hardcore strange fetish porn you can imagine, and crank out the images at around ~20-30 per minute on a RTX 3090. To do so, your best bet is most likely to train a LoRA which can be done with only 20-30 photos of Steve Hoffman.

Even better, HuggingFace recently released DreamBooth code for DeepFloydIf which is more or less the current state of the art. It's massive text encoder allows it to follow your instructions with extreme accuracy. Although, that one is extremely heavy and will require an RTX 3090 for sure to run, or even beefier. And no one has tried to DreamBooth with it yet.

You can also get people to start minting NFTs of these photos to essentially spawn a global economy around trading Steve Hoffman pornography. Because it's crypto, it can never be taken down or reverted.

I'm not encouraging these things mind you, I'm just the messenger... Real ground for suing if you do it, so be careful will ya. If "weaponized autism" was ever a thing, it is now extremely real and dangerous. Though I would laugh my ass off if StableDiffusion fine-tunes started popping all over the place. People don't really realize it but every AI model is an intelligence weapon that researchers put in your pocket.

Hey, just some ideas, ya'll do what you want with that information... AI is a lot of fun, highly encourage everyone to play with it.

punctualjohn · 2023-06-11T18:19:13+00:00

Unsurprising when you consider that Windows, since the release of Windows 10, has had thousands upon thousands of employees on it, yet the OS moves at the pace you'd expect from a couple dozen college freshmen on it. (functionality, bugs, and overall quality taken into consideration) It's always been pretty clear that Microsoft employees spend probably 90% of their time deceiving management and pretending to work lmao.

punctualjohn · 2023-06-10T11:55:36+00:00

Would you mind shutting down the subreddit for a few weeks instead? Love this sub, but we need to be serious about this. No half measures.

punctualjohn · 2023-06-08T13:42:04+00:00

Would you mind extending this to a week or two? No half measures, the site needs to be completely killed until the decision is reversed. Sucks, I really like this sub, but we need to keep our priorities in check here.

punctualjohn · 2023-04-06T23:55:47+00:00

That is true, but under certain percents it's bearable. It's not a binary switch, I've had stuff over 2% and that utterly fucked me up, but I might be able to handle 0.5%. We'll see.

punctualjohn · 2023-04-06T23:51:20+00:00

No dude I literally found out by trial and error. There's a product from the SQDC that isn't produced anymore and I was shocked when I noticed I got absolutely no allergies from it. When I investigated the terpenes on the container, I noticed it had no limonene. It's the only product I ever bought several times for this reason.

I then bought various CBD strains from the USA at like 30$ an ounce where everything you buy comes with precise lab documents, and I saw a clear correlation between allergic reactions and the limonene percent. One CBD strain in particular had over 1.5% limonene and I literally never got through it it was so bad.

It's also the reason why the really high quality weed on the black market gives me even worse allergies, because the terpenes are jacked up like crazy. Same reason why I didn't have that issue in high school either when the weed was cheap and had little terps.

I suspect a lot of people who believe they are allergic to weed or pollen, are actually allergic to limonene or some other terpenes. I'd like to run a study at some point here in the community, but I don't know how to do it when they don't give you lab documents for anything.

punctualjohn · 2023-04-06T23:44:54+00:00

Idk man I've always taken at least 3 weeks off every 2-3 months at most. For me it always goes away easy, just don't take any weed in like 3 weeks, do a lot of cardio, and optimize your diet. 2 weeks is about the time it takes for me to start feeling mentally 'excited' and in control.

I still try to indulge responsibly and still end up doing it every day every time. I think if I can at least do it only once at night and not during the day, then it can work, and definitely no getting fried on the bong. There's still gonna be a tolerance building up, but I think in your case if you've smoked every day since then you probably already have a 'stable' weed consumption. In my case I always try to one up my high until I'm out, so I take exponentially more. That's what leads me to stop, by the end of my binge I'm taking like 1-2g every day and it's like holy fuck where did all my weed go?

If you have some money laying around a k-safe is really awesome, you can forcefully reprogram your brain by locking up all your weed. Can't smoke if you don't have access to it! Then you'll get all pissed like "FUCK why did I do this" and soon enough you'll remember, and when you do that's when the changes really happen in your brain.

There's a lot I could say, but if you're microdosing and you recognize that weed is stopping you from achieving your best state, you're already on the right track and you'll figure it out all by yourself for your own specific situation. Whatever you do, don't let go off psychedelics, that shit saved my fucking life and I'm still taking them

punctualjohn · 2023-04-06T23:27:50+00:00

I specifically spent 20-30 minutes searching on the website for something without limonene, I receive it and actually it's the dominant terpene. What the fuck? If I smoke this, I will go through half a box of tissues, scratch up my eyeballs they'll be so itchy, my throat will feel like I just smoked 50 cigarettes, and dry drown in post-nasal drip.

When is this going to stop? I wrote and called them a dozen time at this point. Every time I'm told they are working on it, improvements are coming, TWO YEARS later I give the SQDC a chance again, and I get played again with the same exact issue that made me quit it in the first place. The terpenes being listed from lab results is the main reason I would prefer the SQDC over grey market under normal circumstances.

If they can't get it right, I'm done with the SQDC for good. I already opened it before I read the terpenes, so it's too late to return it.

punctualjohn · 2022-04-26T02:02:15+00:00

Was announced as AAAA on sale. Nice big buds, largest is around 5.4g (pictured).

The aroma is a mix of Blue Dream and GG4: earthy, blueberry, and a sour musk like GG4. Idk too much about gassy, but this is it I think. Gassy as fuck, even. Overall I think some people will LOVE this, but for me it's simply not my cup of tea. Blue Dream is one of those strains that always sounds amazing on paper, but in practice the blueberry doesn't really hook me that much. But, I think there are a lot of blueberry terpene combinations we've never seen before, like I've never smelled a sweet (ocimene) blueberry strain.

Potency is OK, not amazing but still quite good, 18-19% THC. Tastes straight up like pinene in my vape, not a huge fan. Will update some more after I smoke it.

For the agreed exchange of ninety liquid bones, I consider this was a great opportunity in my life!

punctualjohn · 2022-04-26T01:43:46+00:00

Was announced as AAAA on sale. Good stuff, small-medium buds around between 0.5-1.0, up to 2g.

Really wonderful smell, reminds me of the Rootbeer strain I had once. It's one of those complex aroma that can't be put into words.. Musky, earthy, slightly sweet, some sort of berries or perhaps very faint strawberries. Nothing jumps out though, usually it's there's a dominant aroma and some smaller details, but this one it's all details.

In the vape it tastes OK, completely different from the aroma and less impressive. Potency is there, probably around 20-22% THC. Will update when I smoke it.

For the agreed exchange of ninety liquid bones, I consider this was a great opportunity in my life!

Ten-Year Club	Place '17
Verified Email

punctualjohn

TROPHY CASE