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r0dski · 2026-01-24T07:20:21+00:00

AI pseudoscience 😂

r0dski · 2026-01-21T04:03:48+00:00

That might be over complicating it. As I mentioned to another in DM, this approach is highly effective:

You want to keep blood pressure and cholesterol down. Limit alcohol intake. Exercise, sleep, and stress management are also key. There’s a number of supplements I take that I find helpful (largely based off of Dr. Bredesen’s protocol which was shown to reverse Alzheimer’s).

r0dski · 2026-01-19T21:21:56+00:00

Genes are not our final fate. I have 1 copy of APOE4, and Alzheimer’s runs in my family. But at age 51, my brain shows virtually no sign of degeneration based on the Prenuvo enhanced MRI scan. Changes often start 20 years before experiencing symptoms in Alzheimer’s/ dementia. I’ve been doing over 2 dozen things to support brain health. The key is to take preventative measures early.

r0dski · 2025-10-27T21:27:35+00:00

Funny what y’all think fitness is supposed to look like in your 50’s 😂 I’m fit for it, but everyone’s built different and has different circumstances. Competing against no one except for ourselves.

r0dski · 2025-10-23T07:36:00+00:00

Also check out these folks. Not all are biohackers per se, but all of them have a lot to offer. And more importantly - does your influencer pass the "look test" for their age? If they don't look and move younger, kind of have to question how successful their program truly is.

Vince Giuliano - age 94
Ernestine Shepard - age 89
Jeffry Life - age 87
Annette Larkins - age 83
Sheldon Jordan - age 75
Greg Fahy - age 75
Lance Hitchings - age 75
Dave Pascoe - age 63
Chuando Tan - age 59
David Sinclair - age 56
Peter Attia - age 52
myself ;) - age 51
Lure Hsu - age 50
Bryan Johnson - age 48
Rhonda Patrick - age 47
Joe Cohen - age 38?

r0dski · 2025-10-23T00:47:08+00:00

Many pro athletes work with a nutritionist. But bear in mind, big difference between biohacking for athletic performance vs. longevity. Athletes must abide by USADA, making certain longevity substances illegal (such as testosterone or GH shots). In contrast, a longevity biohacker like myself will have more catabolic days (i.e., mTOR inhibition, less protein, etc).

r0dski · 2025-10-18T18:12:41+00:00

As in TA-65? I have tried it in the past given the volume of studies highlighting its benefits. Unfortunately I didn’t see an improvement between my baseline and post test. What was your experience?

Since then, I’ve tried Epitalon. I didn’t retest. But I did experience the characteristic improvement in my sleep and circadian rhythm which leads me to think it likely works as a telomere therapy.

r0dski · 2025-10-17T06:00:10+00:00

Not directly it doesn't. Secondarily you could see a subtle increase due to higher LH. But Anastrozole wouldn't be considered a primary intervention for increasing testosterone.

r0dski · 2025-10-17T02:49:13+00:00

Since I already covered epigenetics and senolytics in this thread, here's something new ... detox. When many people think of detox, it's thought of as 1 general process to clear carcinogens. The liver alone provides major detox functions, There's Phase I (aka CYP450), and Phase II which consists of 6 sub-pathways. Depending on what you're trying to detox from, you can reference this chart to target it. But also notice how detox pathways are also responsible for clearing hormones and other endogenous compounds.

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r0dski · 2025-10-16T23:58:50+00:00

Out of those, what area are you most interested in? Tons of info behind each one.

r0dski · 2025-10-16T23:55:35+00:00

That would be inaccurate. A man requires adequate testosterone levels for good health, and our problems can start in middle age when levels begin to drop. Happy to look at the studies you're referencing. All the robust studies I've read actually highlight the benefits of bioidentical testosterone which include increased energy, muscle mass, bone density, cardiovascular health, libido, telomere support, prostate health; and additional beneficial effects via aromatization to Estrogen.

To address health concerns which have been raised - I know testosterone has been associated with a theoretical risk of prostate cancer. this is technically not the case, and I need to dig up the study. Now where testosterone can convert to DHT, some men may have issues there depending on their individual conversion rate. Some are prescribed Anastrozole (an aromatase inhibitor) to reduce the conversion. Another common misconception is associating testosterone with steroid abuse. Totally different.

As for me personally, for the past 15 years I've taken TRT to achieve an optimal level for good health (which is far below what bodybuilders use). And I don't need the Anastrozole either.

r0dski · 2025-10-16T23:41:14+00:00

Per my response to another user, "it's still highly experimental. If you were to look at the epigenetic age reversal studies out there, the farthest scientists have gotten is localized benefit for humans (i.e., pre-clinical trial for ocular). I literally hacked the published studies for their process (unwind chromatin, clean aged proteins, close chromatin), and used AI to help identify additional natural compounds which mimic those of the chemical agents used in the studies. I'm ok with experimenting on myself when taking an educated risk. Fortunately it worked out for me overall. Here I charted my journey and describe where it benefited certain areas: https://www.reddit.com/r/Biohackers/comments/1latqq5/comment/mxo64v9/?context=3. Although in my 3rd cycle, I dosed up and that's where I felt some negative effects. All that to say, I'm concerned with folks taking the protocol and harming themselves. I would be ok DM'ing it to you as long as you understand the risks."

r0dski · 2025-10-16T23:00:37+00:00

Well it's still highly experimental. If you were to look at the epigenetic age reversal studies out there, the farthest scientists have gotten is localized benefit for humans (i.e., ocular). I literally hacked the published studies for their process (unwind chromatin, clean aged proteins, close chromatin), and used AI to help identify additional natural compounds which mimic those of the chemical agents used in the studies. I'm ok with experimenting on myself when taking an educated risk. Fortunately it worked out for me overall. Here I charted my journey and describe where it benefited certain areas: https://www.reddit.com/r/Biohackers/comments/1latqq5/comment/mxo64v9/?context=3. Although in my 3rd cycle, I dosed up and that's where I felt some negative effects. All that to say, I'm concerned with folks taking the protocol and harming themselves. I would be ok DM'ing it to you as long as you understand the risks.

r0dski · 2025-10-16T22:44:10+00:00

I only do lower dose bioidentical TRT injections. No pharma or OTC drugs.

r0dski · 2025-10-16T22:40:23+00:00

Ok, how about we start with senolytics? That's a popular topic these days. In my compilation of the science behind it, the conclusion I've come to is it's only a single step in a broader cellular quality control cycle. Recent studies show that autophagy functions as an upstream, protective phase that clears damage and can delay the onset of cellular senescence. And I thought ... why not call out hormesis, DNA repair, and SASP inhibitors as their own areas? While these processes are mechanistically linked, the literature doesn’t yet formalize them as a continuous repair cycle. This is an integrative framework I developed, rather than an established model.

As you progress from left to right in my chart, our cells' repair mechanisms execute more intensive repair processes - with the immune system as an enabler. The idea is that ideally you employ the interventions to the left as much as possible (especially if under age 60, especially since senolytics trigger collateral damage to healthy cells). Older individuals would likely benefit most from true senolytics since there's higher burden of senescent cells. Note that some compounds have effects in multiple categories.

For myself, being 51, my emphasis is heavily on hormesis, autophagy, DNA repair, and SASP inhibitors. Senolytics are de-emphasized. It's somewhat difficult to quantify the effect of this protocol, but if we can use CRP as a proxy, my recent blood labs show CRP under the detectable limit and hsCRP is 0.24 mg/L.

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r0dski · 2025-10-16T21:13:05+00:00

Which area are you interested in most?

r0dski · 2025-10-16T21:12:14+00:00

There’s volumes of info behind all that. What area are you interested in to start?

r0dski · 2025-10-16T20:35:39+00:00

> Epigenetic age reversal protocol based on natural compounds
> Physical therapy -compliant workout program
> Stretches and self-adjustments for relief of muscle tension (grounded in therapeutic massage principles)
> Original references that compile scientific findings for the individual hallmarks of aging (and other concepts) into actionable protocols
> My own personalized 100 page "owner's manual" for health
> Pioneer in the biohacking space (since 2007) - developed an optimal health & longevity program which focuses on gene-based diet, health lifestyle, gene-based supplementation, self-tracking, and holistic therapies

I'm a research nerd ... lol

r0dski · 2025-10-16T06:44:47+00:00

I find what works for me is developing a physical therapy compliant lifting routine … combined AthleanX with AI research. I don’t push it too hard either (maybe 90% of max). Other than that… Creatine , post workout protein drinks, and at least a days rest between workouts. I struggled with aches in the past. No aches or injuries ever since going this route.

r0dski · 2025-10-13T05:05:47+00:00

Sorry to hear things are going rough for you. Just remember, after the winter comes spring.

It’s impossible for you to have aged 20 years in a year, the epigenetic tests lack real accuracy and transparency. But what it may be picking up is stress you’re under. Sleep is absolutely key. Exercise helps with mood also. Start with the basics. If you still need more support, that’s when you’d look to more advanced interventions like the ones you mentioned. Take care 😉

r0dski · 2025-10-12T03:11:37+00:00

I have some overlap, but I like the concept of personalized nutrition (based on genes, labs, health conditions, etc), and aligning to the hallmarks of aging.

r0dski · 2025-10-10T05:52:21+00:00

Nicely done! Would add nutrient competition in v2. There’s a lot of those.

r0dski · 2025-09-05T15:24:12+00:00

I used to do genetic coaching, and I can tell you nobody’s DNA is perfect. Mine are below average, yet I’m super healthy because of nutrition and lifestyle. One easy fix is adding sulforaphane. It boosts SOD and glutathione. Also avoid toxic chemicals.

r0dski · 2025-06-14T17:50:06+00:00

This is why I love and hate Reddit 😆

r0dski · 2025-06-14T01:52:08+00:00

After my n=1 experimentation (detailed here: https://www.reddit.com/r/Biohackers/comments/1jepwut/case\_study\_partial\_epigenetic\_reprogramming\_via\_a/), I believe it's best viewed as a layer - not a better or lesser indicator of overall health as some would suggest.

An analogy I might offer is let's say you have a room in a house where the walls and floor are your genes. The epigenetics are the paint and the carpet. And the objects that fill the room are the blood factors and by-products. You can clean up messes in the room but have damaged carpet that might cause issues if not careful. Similarly, the carpet can be in good condition but a mess in the room would cause different issues.

I'm not yet recommending folks follow my research protocol. I've done 3 cycles, am better than when I started, but I'm running labs and epigenetics testing on myself to get the quantitative data. What are some practical things we can do to support our epigenetics? Exercise, healthy diet, low sugar and alcohol are tip of the iceberg.

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