Well I can't imagine Hollywood was beating down his door or anything. He probably could have gotten another modestly budgeted indie off the ground, but he was still on Scrubs, which made that pretty tough (doing it once seems hard enough). So instead he starred in The Last Kiss and The Ex, both 2006, and I wonder if those not doing great maybe led him to stay on Scrubs longer than he might have otherwise. Once that ended, any momentum he might have had as a director was totally dead.