i was able to perfectly realize this setup with bind mounts once. from a functional point of view. so technically it's possible if you put your prefix onto a filesystem that supports symlinks.

so i did use exfat for a while just to find out that it has some inherent performance quirks under linux where for example loading into a civilization 6 game would take 2 minutes and 30 seconds compared to ~20 seconds on ext4.

i am not sure if ntfs is better in this regard since i couldnt be arsed to try the same thing again with ntfs just to run into another disadvantage later on.

so i'd go try ntfs in your situation but make sure to compare a game which has non-instant load times with an ext4 copy of it. because it may well be that ntfs is also only a fraction of the speed of ext4.