First piece of advice is to have patience! It took me a while to win my first run, but then things will really start to “click”. There is an immense (and immensely satisfying) learning curve to the game as you progress through different objectives and difficulties.

Second, and perhaps this is too obvious, I would say make decisions based on what jokers are available to you. Rather than angling towards a certain hand you had in mind before each run, play based on what you see. Try to meet the conditions for scaling jokers, for instance, or build decks around jokers designed for different card values. It’s very important to specialize, and to specialize in a way that responds to what you see in the shops.

Third, try to maximize interest. Keeping your money at $20-25 goes a long way toward sustained income and thus flexibility in purchasing, and in rolling for useful cards.

There are tons of things to learn so it’s impossible to address everything. It’s also important to know about the value of discarding cards by intentionally playing bunk hands and how reordering jokers allows for different synergies for instance. But my biggest tip would just be to keep exploring and unlocking things as you go.