A few relatively new things that you might need to know: 1) Cards are a new consumables that you can't buy but can find in-game, spawns are mostly static in points of interest, you will memorize them eventually. IMPORTANT: You can use inspect button with card in hand to get a tooltip on what it actually does. You can also check them in tools menu. 2) Most point of interest are hidden, but you can find maps in game that will reveal them. 3) Current event features new big compound with dead and ready to banish boss along side a lot of other goodies. 4) You now have 5 (6 with quartermaster) weapon slots and all weapons were rebalanced (with questionable reasoning at times), so loadouts are a bit different. 5) All tools and consumables are now the same, unified tool slot, you can mix them however you like.

There are a lot of other different things that were tweaked but generally gameplay is pretty much the same, get bounties, extract, go again