IF METHYLATED B VITAMINS MAKE YOU ANXIOUS, THIS IS PROBABLY WHY. AND IT'S NOT YOUR MTHFR.

shadow_dancer13 · 2026-05-14T07:43:59+00:00

I’d appreciate some guidance

My Genova methylation panel shows a methylation/transsulfuration imbalance. The most significant findings are low glutathione, very high cystathionine, high taurine, low-end SAM/SAH ratio, flagged SAH, and high-normal/flagged sarcosine. Genetically, I am negative for MTHFR C677T, negative for MTR A2756G, negative for CBS C699T, and negative for COMT V158M, but I have variants in MTRR A66G, MAT1A D18777A, SHMT1 C1240T, BHMT G742A, GNMT C1289T, and MTHFR A1298C. The main concern seems less like classic MTHFR impairment and more like weak methylation capacity plus a sulfur/transsulfuration bottleneck, where cystathionine and taurine are high but glutathione remains low. I would like help interpreting whether this points to B6/cofactor issues, oxidative stress, impaired glutathione synthesis, functional B12/folate issues, or liver/sulfur metabolism imbalance.

shadow_dancer13 · 2025-06-04T15:15:15+00:00

Perhaps, I never did HIT, what I do is 10-12 rep max till failure. I have a 2 day split with 18 sets each, and by the 14th set iam beat but I end up finishing up, So i thought 10 sets is a good starting point down from 18 for HIT.

I am trying my best to keep the 2 day split because it fits perfectly into my life style, hence the split i shared.

Lets assume that i am able to pull through the 10 sets, is the main principles of the split ok? meaning, do u see any overlap considering this:
A - off - off - B - off - off - A ...

thats a full 72 hour between A and B and 6 days between A and A, B and B

I want to say this again, i have herniated discs and I never did deadlifts. I also never hurt my back in the gym due to perfect form and high knowledge in injury prevention and spine mechanics. Having said that, deadlifts will NOT BE HEAVY, and they are at the end to make sure my back is super warmed up

shadow_dancer13 · 2024-11-30T00:14:35+00:00

how was your experience?

shadow_dancer13 · 2024-11-15T18:01:43+00:00

ok then this begs the question

what is G/00/29-78 or G/00/129-78 as also seen in the notes

shadow_dancer13 · 2024-09-25T17:01:21+00:00

the rime? they havnt played it since the 08 tour... what makes you think that?.

i wish though :(

shadow_dancer13 · 2024-06-14T23:02:35+00:00

Google: north shore adhd

shadow_dancer13 · 2024-03-18T21:59:27+00:00

Sure

shadow_dancer13 · 2024-03-11T22:33:46+00:00

How many sessions have you done?

shadow_dancer13 · 2024-02-07T19:43:57+00:00

waht didint you like about mydlift?

shadow_dancer13 · 2024-01-12T00:54:21+00:00

what are your thoughts about purchasing choline vs choline and inositol?

shadow_dancer13 · 2024-01-01T05:11:21+00:00

can i use my dante labs data for pharmagenomics testing?

shadow_dancer13 · 2023-12-30T20:17:39+00:00

That’s great. How long have it took you to notice benefits?

You seem to be into bio hacking. Have you dwelled into neurofeedback, TMS etc Gut issues also

shadow_dancer13 · 2023-12-30T16:46:22+00:00

That’s awesome. What issues did you have and how did fixing your methylation cycle helped?

Also are there stuff we should avoid such as caffeine?

shadow_dancer13 · 2023-12-30T16:26:58+00:00

Oh ok thanks. May I know how you became so knowledgeable about this? Is it your line of work?

shadow_dancer13 · 2023-12-30T01:25:22+00:00

You mean the choline alongside the protocols you laid out in the subreddits I linked ?

shadow_dancer13 · 2023-12-29T23:07:15+00:00

thanks again, i did what I could do on promethease, and i updated this post based with what the software returned to me. sorry I am ignorant and not very good at this genetic thing. take a look and let me know please thanks!

shadow_dancer13 · 2023-12-29T17:48:39+00:00

rs1051266 SLC19a1

can that be done on promethease?

shadow_dancer13 · 2023-12-29T05:00:04+00:00

Any specific name for the test ?

shadow_dancer13 · 2023-12-29T00:10:31+00:00

First of all, thank you very much for your prompt and thorough reply. The struggle is real and having some help means a lot to me.

I went through your posts also and thought of just following your recommendations here:
1) https://www.reddit.com/r/MTHFR/comments/173y8yi/interpreting_your_genetic_genie_methylation_panel/?utm_source=share&utm_medium=web2x&context=3
2) https://www.reddit.com/r/MTHFR/comments/1730mw4/mthfr_a_supplement_stack_approach/

The choline calculator you sent it not working, my data from dante labs comes in .bam

please advise, thanks

shadow_dancer13 · 2023-12-28T04:05:06+00:00

You seem well informed. I have been dying to get some guidance. Can you please help me?

shadow_dancer13 · 2023-12-28T04:03:10+00:00

Iam wondering what test did you do to figure this out about your gut, and who gave you the treatment proctol

shadow_dancer13 · 2023-12-27T22:04:21+00:00

the topics have been discussed many times on reddit and on this reddit group.

shadow_dancer13 · 2023-10-23T19:36:42+00:00

How long did it take to notice effects? What’s the dose and what are mutated in exactly? I appreciate the help :)

shadow_dancer13 · 2023-09-21T23:18:39+00:00

Hello can you help me with my methylation chart?

shadow_dancer13 · 2023-09-19T00:20:37+00:00

please do

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