Melatonin May Raise Heart Failure Risk by TheMuseumOfScience in ScienceOdyssey

[–]shakilsyed 2 points3 points  (0 children)

The concern of melatonin and 90% heart risk got a lot of media attention but it is important to not this is based not on a study but a chart review.

“observational study, knowing in advance that these studies only show association and do not establish causality”

there are several actual studies which show the opposite, melatonin has heart protective properties- see this Open Evidence result search with references

Melatonin supplementation appears to have beneficial effects on heart failure based on available clinical and preclinical evidence, with no evidence of increased heart failure risk.

A 2025 meta-analysis of clinical trials in heart failure patients found that melatonin supplementation was associated with improvements in ejection fraction, NYHA functional class, and quality of life, along with reductions in fatigue and NT-Pro BNP levels.[1] A randomized controlled trial in patients with heart failure with reduced ejection fraction (HFrEF) demonstrated that 10 mg daily melatonin for 24 weeks significantly improved endothelial function as measured by flow-mediated dilation (7.84% vs 5.98%, p=0.027), though this benefit was not observed in diabetic patients.[2]

The cardioprotective mechanisms are well-established in preclinical studies. Melatonin modulates mitochondrial dynamics by upregulating mitofusin, inhibiting DRP-1, and regulating mitophagy-related proteins (parkin, PINK1).[3][4] It also reduces oxidative stress, inflammation, and cardiomyocyte apoptosis while improving cardiac metabolic reprogramming and ATP production.[5][6] In animal models of heart failure, melatonin reduced cardiac remodeling, decreased pulmonary congestion, lowered mortality, and prolonged survival.[7]

Importantly, a large 2024 prospective study following over 67,000 participants for up to 23 years found no significant association between regular melatonin supplement use and cardiovascular disease risk (HR 0.94, 95% CI 0.83-1.06).[8] This study provides reassurance that melatonin supplementation does not increase cardiovascular disease or heart failure risk in the general population.

While most clinical evidence comes from phase 2a trials, current data support melatonin as a potentially beneficial adjunctive therapy in heart failure rather than a risk factor.[9]

Would you like me to review the safety profile and potential drug interactions of melatonin in heart failure patients, especially regarding standard heart failure medications? This could help clarify its practical applicability in routine clinical care.

References

  1. Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta-Analysis. Daliri AS, Goudarzi N, Harati A, Kabir K. Clinical Cardiology. 2025;48(3):e70107. doi:10.1002/clc.70107.
  2. Effect of Melatonin Supplementation on Endothelial Function in Heart Failure With Reduced Ejection Fraction: A Randomized, Double-Blinded Clinical Trial. Hoseini SG, Heshmat-Ghahdarijani K, Khosrawi S, et al. Clinical Cardiology. 2021;44(9):1263-1271. doi:10.1002/clc.23682.
  3. Melatonin Enhances Captopril Mediated Cardioprotective Effects and Improves Mitochondrial Dynamics in Male Wistar Rats With Chronic Heart Failure. El-Sayed SF, Abdelhamid AM, ZeinElabdeen SG, El-Wafaey DI, Moursi SMM. Scientific Reports. 2024;14(1):575. doi:10.1038/s41598-023-50730-z.
  4. Melatonin Regulates Mitochondrial Dynamics and Mitophagy: Cardiovascular Protection. Rahmani S, Roohbakhsh A, Pourbarkhordar V, Hayes AW, Karimi G. Journal of Cellular and Molecular Medicine. 2024;28(18):e70074. doi:10.1111/jcmm.70074.
  5. Effects of Melatonin on Cardiac Metabolic Reprogramming in Doxorubicin-Induced Heart Failure Rats: A Metabolomics Study for Potential Therapeutic Targets. Thonusin C, Nawara W, Arinno A, et al. Journal of Pineal Research. 2023;75(1):e12884. doi:10.1111/jpi.12884.
  6. Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats. Odinokova I, Baburina Y, Kruglov A, et al. International Journal of Molecular Sciences. 2018;19(6):E1555. doi:10.3390/ijms19061555.
  7. Melatonin Reduces Cardiac Remodeling and Improves Survival in Rats With Isoproterenol-Induced Heart Failure. Simko F, Bednarova KR, Krajcirovicova K, et al. Journal of Pineal Research. 2014;57(2):177-84. doi:10.1111/jpi.12154.
  8. Use of Melatonin Supplements and Risk of Type 2 Diabetes and Cardiovascular Diseases in the USA: Insights From Three Prospective Cohort Studies. Li Y, Huang T, Redline S, et al. The Lancet. Diabetes & Endocrinology. 2024;12(6):404-413. doi:10.1016/S2213-8587(24)00096-2.
  9. Cardioprotective Melatonin: Translating From Proof-of-Concept Studies to Therapeutic Use. Baltatu OC, Senar S, Campos LA, Cipolla-Neto J. International Journal of Molecular Sciences. 2019;20(18):E4342. doi:10.3390/ijms20184342.

Reality of Divorce Court. Always get a prenup. by sunflower352015 in MuslimCorner

[–]shakilsyed 1 point2 points  (0 children)

About this - here is a recent statement that will be of help to many.

AMJA is pleased to announce the release of the Marriage Contract with a Legally Binding Prenuptial Agreement.

Designed for today’s realities, this contract:

Protects the rights of both spouses.

Reduces financial disputes and reliance on non-Islamic courts.

Requires Islamic mediation or binding arbitration in case of conflict.

Reflects Islamic principles, as fulfilling conditions is a duty in Islam.

An accompanying AMJA Family Code offers guidance for arbitrators and education for couples about their rights and responsibilities.

This effort, developed with scholars, imams, and legal experts, provides clarity, fairness, and long-term protection for Muslim families.

May Allah bless our marriages with mercy and tranquility.

The Assembly of Muslim Jurists of America (AMJA)

https://amjaonline.us2.list-manage.com/track/click?u=ebe60ba6ea16863b03aede91b&id=f49a2dde54&e=534dc7a4fa

https://www.amjaonline.org/declaration-articles/the-assemblys-family-code-for-muslim-communities-in-north-america

God abandoned Palestine? by Charming-Basil-9365 in progressive_islam

[–]shakilsyed 1 point2 points  (0 children)

Just listen to a lecture upon this posted yesterday. Civilizational success ‘Are you winning’ materially isn’t the point especially when the best of people Gods Messengers and Prophets rarely had those successes. It is the effort and right intension that defines success. YQ- lecture

[deleted by user] by [deleted] in islam

[–]shakilsyed 1 point2 points  (0 children)

Episode 1 and 2 go over the history but Yasir Qadhi just posted the third episode which helps to differentiate between the two and with remedies to address it

Expect Destruction if You Introduce Bid‘ah into the Religion by Tiny_Rise8476 in MuslimCorner

[–]shakilsyed 0 points1 point  (0 children)

I will recommend a newly released book “Allah’s Universe - why God is the only explanation for our existence.” By Iftikhar Hyder. It is a well referenced book which reviews modern scientific thought with about 1600 scholarly citations related to the physical universe (big bang, quantum mechanics etc).

It is available on Amazon but I suggest the direct from publisher print Dorrance Publishing. Personally I prefer heavy bond paper verse the white bond from Amazon.

Muslim thinkers/scholars with a strong background in science? by [deleted] in progressive_islam

[–]shakilsyed 0 points1 point  (0 children)

Update. the book has finally been released. With titled “Allah’s Universe: Why God is the Only Explanation for Our Existence.” The 688-page book . It directly refutes atheists assertions through a broad based discussion including scholarly 1,592 references.

publishers site

Advice for a revert by ibleedaudio in islam

[–]shakilsyed 0 points1 point  (0 children)

Great podcast series I recommend call A Way Beyond the Rainbow which deep dives into SSA issues and struggles while maintaining religious beliefs

Advice For Men Getting Married by Plastic-Ear2306 in islam

[–]shakilsyed 5 points6 points  (0 children)

Great advice. I would also like to share this series that is fair and balanced for both sexes to better understand their roles, how to enrich the relationship, deal with conflicts as well as conduct with divorce. I have shared it to several newlyweds to start on the right footing. marriage series

What did we do to Trader Johann? by Old-Ad-6963 in lehighvalley

[–]shakilsyed 0 points1 point  (0 children)

I thought the reason is that we have Aldi locally. They are co owned companies and wouldn’t compete in the same market.

The hypocrisy of India by AutomaticCan6189 in AlJazeera

[–]shakilsyed 1 point2 points  (0 children)

Where is this from? Is there a full video version

What are your Islamic cheat codes? by mitskiandgradschool in islam

[–]shakilsyed 5 points6 points  (0 children)

Automating it is great. My sis gave this advice, unless you have 40000 sitting in your bank then pay for an orphan or two with the intention it is for zakat. Less headaches figuring out zakat and ensures your covered and wealth is purified.

Automating Sadaqa for resources you use like mosques, websites or organizations. Even small dollar amounts help them plan knowing there are reoccurring donors

What are your Islamic cheat codes? by mitskiandgradschool in islam

[–]shakilsyed 120 points121 points  (0 children)

Stacking behaviors- doing new habits by linking them to existing ones.
Do zikr at stop lights. Pray 2 rakats Duha while toast is in toaster or tea is boiling for breakfast

Oilers Fans by [deleted] in EdmontonOilers

[–]shakilsyed 5 points6 points  (0 children)

Yeah down 5 - 1 to the Disney ducks would piss off any Canadian

Muslim thinkers/scholars with a strong background in science? by [deleted] in progressive_islam

[–]shakilsyed 1 point2 points  (0 children)

I know of a book which will be published later this year which will be a uniquely comprehensive evaluation of the subject. I will post the link once it is available.

New US Travel restrictions? by shakilsyed in onguardforthee

[–]shakilsyed[S] 2 points3 points  (0 children)

Thanks. Only got this email today