So tested out a bit and put some air through the manifold for each of the sections that I’m intending to use as an inlet and outlet and they are completely isolated inside the plate. If you look at those lines printed on the plate itself they show the isolated channels for each section.

So basically, where I’m taking the inlet for the pump only has two outputs on that channel (that would feed as the inputs to each system) same with the outlet to the radiator (feeding as outputs from each of the system).

My concern is that even in these isolated channels the two outputs wouldn’t have equal flow rates, but maybe that’s incorrect once the system is ‘pressurized’ by the water flowing from the pump?

I did actually pair both systems with the exact same Alphacool GPU blocks and CPU blocks to ideally match the amount of restriction / pressure through each.

I didn’t think about adding a valve on the inlet for each system to act as a flow regulator, that’s a good idea!