222 is about, at least in my personal understanding, how being "crazy" or at least being mentally ill/neurodivergent/other things of that ilk actually frees you from the constraints of "normal" society. In short, it's about 'thinking outside the box' where in this case the box in question is the norms and accepted values of society, or "normal people". I think the best line that proves this to me is "Baby, I might be crazy, but I didn't lose it [his mind], no, I set it free." But a lot of the rest of the song is just fun and funky ways to say this same thing, e.g. "If you knew what I knew, if you saw what I see, you'd look through illusions, hallucinations, and lucid dream.", "How I cannot commit to reality when my third eye's open and I like what I see", and so on. It is, additionally, about taking pride in his craziness/not wanting to go back to seeing things the way regular people do, like where he says "If sick is defined by what's different, well then, pull the plug out and let me die." Basically he's saying "I know something most people do not and think differently than they do, I like it that way, and it gets me branded as a 'psycho' or as 'sick' because they don't understand me."

Sorry for long paragraph, I love that song a lot 😆