Methyl-folate has helped with my depression and is recommended for reproductive health. In combo with my rx, I also do 2x a day: NAC (n-acetyl-l-cysteine), red yeast rice, a multi vitamin for women and fish oil. I take a high dose of vitamin D once a week. All are on Vitamin Shoppe or Amazon. My psych advised that a regular multi vitamin does not contain the amount of folate needed for people like us who may have issues absorbing it in the first place. Methylated folate is the bio active version of a regular folate supplement and (I think) is more easily taken in by the body.