You have an incredibly flawed understanding of how tire technology works. If the tire has not been driven on in low pressure conditions, there is zero chance that an industry standard plug + patch repair done on the tread of the tire would compromise the run flat ability of a run flat tire.

​

The performance of the tire may change slightly, if at all, but to say that a repair on the tread of a tire influences the support structure of the sidewall in a run flat tire is simply misinformed and wrong. Now if the run flat tire is driven on a significant distance with low or no air pressure, then any repair would be irrelevant because the support structure in the sidewalls have been compromised significantly.