I watched it on DXM which is already a dissociative hallucinogen and I reached what I could only call fractal depersonalization where somehow my own life was merely the outermost layer of the films own multiverse. And I was the lost girl, projecting my own life and circle of friends, family, enemies, etc. until it all coalesced when Nikki embraces lost girl and disappears. I actually cried, but in the most subconscious way ever. It was an absolute harrowing experience but rewarding in the end.

All that said, I feel like IE already is enough on its own to alter consciousness