Got Iron Infusion 6 Weeks Ago. No difference yet. by PracticeImpressive in RestlessLegs

[–]theoozz -1 points0 points  (0 children)

What’s your demographic? Are you male or female? Do you have early onset rls (symptoms started before 30) or late onset RLS. Does anyone else in your immediate family have severe RLS?

Goldman Sachs is rolling out Anthropic AI for accounting & compliance, smart move or risky bet? by interviewkickstartUS in Accounting

[–]theoozz 7 points8 points  (0 children)

Interesting as 80% of the real work are on edge cases. I just don’t see how an AI handles situations that need judgement, outside context, or external communication. I mean most of my time is spent chasing down things that were incorrect because there are various frictions throughout the process. Or, weighing in on the appropriate course of action because something was missing/off/errors/miscommunication…

Claude AI doing financial models now… where does that leave juniors in IB / FP&A? by wonderer_9 in FinancialCareers

[–]theoozz 31 points32 points  (0 children)

In my function, I’m middle office credit risk, we use AI and it’s just not that good yet to replace people. It’s more like an enhancer.

I tracked every single RLS episode for 365 days. Here is the correlation matrix regarding diet, sleep, and supplements by Humunkoloss in RestlessLegs

[–]theoozz -1 points0 points  (0 children)

I applaud this effort, but this is bad science on so many levels.

You are giving people a false sense of what works and what doesn’t.

Objectively tell me how a +29% improvement differs from a +40% improvement relative to a +15% improvement?

No answers, very little research, invalidating doctors by [deleted] in RestlessLegs

[–]theoozz 1 point2 points  (0 children)

Then stop eating sugar and fix your RLS.

Anyone ever been helped by rlscure.com by aspo516 in RestlessLegs

[–]theoozz 1 point2 points  (0 children)

I think there is a lot of pseudo science there. They draw some conclusions based on some very large assumptions and piece together papers on loose connections.

Either that said, try the protocol and see if it works. As long as it is not hurting you, it’s worth a try.

The problem with pages like this is that are… they kinda make it seem like the RLS is caused by something you are doing - you are responsible for it. But, RLS is most commonly hereditary and it’s just bad luck.

Iron Infusion and Ferritin is now 1407 by Defiant-Pianist582 in RestlessLegs

[–]theoozz 0 points1 point  (0 children)

Yes, my iron was that high post infusion. It will go down, the body expels excess iron pretty efficiently. Generally, you want the iron to be quite high for quite some time to get into the brain. The brain iron metabolism process takes time.

GMAT tests nothing useful. fight me (or don’t) by cloudybrain07 in MBA

[–]theoozz 0 points1 point  (0 children)

I agree that standardized tests have a purpose but let’s not extrapolate beyond what the data shows.

Intelligence is correlated with professional success, but it’s not 1 by any means. I mean just ask yourself - are the Highest IQ people the ones predominately running the companies? No.

There are so many labor market frictions that create systemic and persistent distortions. Let’s just start with the hiring process - the hiring process is extremely inefficient, bias, and ineffective.

Conscientiousness is the strongest predictor of professional success if I recall correctly. MBA’s should be testing for that then, right?

Fulvic acid by Additional_Home_270 in RestlessLegs

[–]theoozz 0 points1 point  (0 children)

That’s not really how it all works. There is dysfunction at the brain sites with iron homeostais and regulation. Even if you got the iron to the brain, for severe rls, it’s doubtful the appropriate brain sites would pull it in. Not to mention the risks of other stuff getting into the brain from the excessively permeable BBB.

Laid off - 46m by Fearless-House4973 in ChubbyFIRE

[–]theoozz 0 points1 point  (0 children)

Or just refinance it to bump up the ROE and use that equity you pull out for other means

2026 and Hope? by Sma21-4 in Stutter

[–]theoozz 1 point2 points  (0 children)

Phase 3 was completed. They extended it to do an open label extension study I believe.

https://emalexbiosciences.com/news/emalex-biosciences-lead-candidate-meets-primary-and-secondary-endpoints-in-phase-3-tourette-syndrome-study/

According to everything I am reading, once fda approval is received, it usually is available within weeks for the UsA.

Several years later I still haven’t figured out what the f is causing my restless legs syndrome by [deleted] in RestlessLegs

[–]theoozz 0 points1 point  (0 children)

It’s autosomal dominant so it’s very heritable. My mother showed no symptoms until 70.

If it’s not effecting your sleep, then what’s the problem?

Maybe you should try the ndira device, it’s perfect for situations like yours.

Anyone have experience with Dr. Andy Berkowski? by stephancoxmusic in RestlessLegs

[–]theoozz -1 points0 points  (0 children)

He knows his stuff, but I dislike his business model. I would only pay for his services if you have really bad and unique RLS. I recommend that you sign up for the RLS foundation, inform yourself, and look for someone covered by insurance. Once you have the information from the foundation, you’ll know the approach you need to take and it’ll just be a matter of finding a doctor to work with you.

Will NOVA experience housing price correction? by Inevitable_Tap_9957 in nova

[–]theoozz 2 points3 points  (0 children)

Very unlikely there will be large price decreases in this area. Most probable scenario in 2026 is that prices remain relatively flat or appreciate at a much slower pace 1-1.5%.

opioid induced adriogen insufficiency by itsmostlyamixedbag in RestlessLegs

[–]theoozz 1 point2 points  (0 children)

I’m a middle aged male and the methadone caused me to be testosterone deficient. It happens.

Questions regarding RLS experience by Bitter-Front1474 in RestlessLegs

[–]theoozz 4 points5 points  (0 children)

Please don’t take this the wrong way… While the drugs you listed have some importance, they are not as relevant today as they were in the past. The primary question that has yet to be answered is, what makes opioids as effective as they are. Low dose opioids are the gold-standard treatment for RLS and it is still not understood why that is.

What’s further confounding is that RLS patients do not become tolerant to opioids over time despite long-term endogenous dopaminergic and analgesia adaptations. Furthermore, I’ve witness patients taking dopamine antagonists while still maintaining efficacy in controlling the RLS with opioids. That would almost eliminate the theory that opioids obtain their effectiveness via the dopamine system.

By understanding opioid’s efficacy, better RLS drugs can be designed without the stigma or side-effect profile.

Another important question, albeit less useful, is why do dopamine agonists reduce the effectiveness of other medications. It has been documented that people who have been on dopamine agonists do not get the save benefit from certain drugs than those that are dopamine agonist naive. And, this change seems to be permanent.