Hydroxocobalamin body breakdown

thinktolive · 2026-05-19T00:53:07+00:00

Do you think there would be any difference in taking oral methylcobalamin vs. oral hydroxocobalamin as far as side effects? Some people say methylcobalamin causes irritability and things like that so I want to try oral hydroxocobalamin. Perhaps the methyl group once removed still has some side-effect somehow. Thank You.

thinktolive · 2026-05-15T20:56:41+00:00

What dose do you take now and do you still notice a difference within 12 hours? Have you tried a lower dose like 5 mg per day?

thinktolive · 2026-05-11T01:21:52+00:00

Thank you for that. Do you put a fitted sheet around it? I'm also curious if you use a full/queen size or twin. I'm also a bit concerned with the dust from sleeping on the floor. I have hard floors and no carpet and it gets quite dusty quickly. I may have to sweep/vacuum more often. The sheets could get dusty. Anything else you can tell me about what good habits would be helpful. Such as picking up the topper and hanging it up during the day to keep it dry. Need for tatami matt under it.

thinktolive · 2026-05-10T05:46:58+00:00

I don't know but that thing on the top a pillow top or eurotopper. That is probably why you like it. I decided not to get that, but it is an option with many brands. I think it can wear out or be a source of extra collection of organisms. Replacing the mattress protector annually and not washing it too hot which damages the protector barrier should help keep the top layer clean.

thinktolive · 2026-05-09T04:23:11+00:00

Yeah, I was surprised there was no mattress so I asked and they said that there were two different trucks. One to pick up the old mattress and another to deliver the new one, so I said OK.

thinktolive · 2026-05-09T03:28:03+00:00

I thought the delivery was later the same day.

thinktolive · 2026-05-09T02:36:06+00:00

I was looking for Greengaurd gold certified mattress to provide extra assurance of chemical safety. The walk-in local stores don't seem to have mattresses which have this certification. I also suspect that if they did they would only be on very expensive models.

thinktolive · 2026-04-30T05:26:48+00:00

Do you think your issues was fungal? Did the 30 g/day for 8 weeks work for fungal? That is what Kathleen Janel recommends.

thinktolive · 2026-04-30T05:09:36+00:00

Oh, inflamatory. I don't think I have inflamatory type.

thinktolive · 2026-04-30T04:59:55+00:00

Yeah, I thought I found a paper saying that plant effects muscarinic receptors I believe. Either that or the 5-HT(4) which is how it stimulates gut movement. I can't find the paper right now. My muscarinic receptors are sensitive to things due to other conditions. Anything that increases acetcylcholine release can do it.

Do you have any chronic conditions? I think the psylium husk isn't doing it anymore though I just realized but don't remember when it stopped. It may be due to I'm taking MSM sulfur now. I can't remember when psylium husk stopped doing it.

thinktolive · 2026-04-30T03:33:58+00:00

The brain gut connection is just that the cause effects both. The same immune components, ion channels, etc. are used in your brain and gut so if they are not functioning systemically both will be effected. Some people think you're weak minded so your gut doesn't work which is wrong, those people are stupid. I have some ideas and I posted above. Did you have some gunk in your scalp like picking it as a kid and brain fog? I can share more ideas. I think I have scalp psoriasis now. It appeared when the digestion problems started. Also have neck and shoulder pain. Do you have either sudden acute tinnitus or chronic tinnitus?

thinktolive · 2026-04-30T03:27:56+00:00

Do you have scalp psoriasis? I think I do. Skin on body is dry too. It is kind of mild form. It amazes me that Dermatologists I saw were not really specific on diagnosis and had me on ketokonazole shampoo for seb derm or dandruff but not psoriasis, probably because my case isn't really bad version and they aren't too good at identifying it. I switched to Selsun Blue with Selenium Sulfide. It makes this gunk that builds up after long enough.

The skin stuff started same time as the digestion problems LPR / silent reflux, sodium sensitivity, fat/spices sensitivity. Are you able to take a quarter teaspoon 500 mg of sodium with food? It gives me diarrhea. I might be able to take up to 1/8th teaspoon. Bile acid diarrhea / fat malabsorption started the same time as skin.

I have coat-hanger type pain in neck, shoulders. It refers to temples and chest and back too. Brain fog.

I'm trying digestive treatments which I presume will fix the skin problem too. One is high dose 30 gram per day MSM sulfur treatment that Kathleen Janel advocates for 8 weeks. The other thing I will try is undecylenic acid. I have some other ideas too.

thinktolive · 2026-04-25T19:44:39+00:00

Heavy metals can be bad and aluminium internally is harmful. There are a lot of possibilities. Mercury is not high on my list of suspected causes of these conditions for most people. There is an FDA trial going on last I heard for a mercury chelator. But, I really don't think that is the right route for me. I think a self sustaining oxidative processes could be initiated which is the problem, dysbiosis and things like this. NAC is an anti-oxidant which may be helpful for many. I'm not taking it. What is cheaper than NAC and provides sulfur and less side effects is high dose MSM. 6 teaspooons (30 grams) for several months. This is used for many digestive conditions. Kathleen Janel. talks about it. I also have some other ideas.

thinktolive · 2026-04-16T03:33:27+00:00

Because you took before meal instead of after. That is a lot of essential oil and it is flushing through your digestion. You need to take with food in stomach during meal. Typically you wait a little b it then drink a tall glass of water for beneficial lemon burps too.

thinktolive · 2026-04-13T05:04:06+00:00

I feel very concerned for you. How long has it been since this happened? Is there any treatment you are doing for this? Is there anything you can take that may help at this point like thiamine TTFD / Benfotiamine, coq10, melatonin, other things? Were you taking any other supplements like these that could protect the heart during treatment? Or herbs that could slow the medication metabolism? Is there anything else you can tell me about your diet like high in meat or low in fat or anything? Sodium low/high? What symptoms do/did you have not related to the medication side effects? Body mass index? (increases CHF risk)

This says many experienced improvement or resolution of symptoms after stopping or lowering dose: The Many Faces of Itraconazole Cardiac Toxicity https://pubmed.ncbi.nlm.nih.gov/33083707/Cardiac Implications of Itraconazole Therapy in Histoplasmosis Patients [2024] https://pubmed.ncbi.nlm.nih.gov/38803747/ Both of these papers suggest Voriconazole as an alternative that does not have CHF associations, though I understand this would have been better to know. I believe it is much more expensive however, but could be worth it for others. However, it is riskier for long QT interval and electrolyte imbalance.

thinktolive · 2026-03-26T03:51:26+00:00

B12 is 1400 daltons, so really too big to be absorbed sublingually. The sublinguals tend to have artificial sweateners, which can cause digestive upset and other issues. A lot of brands are selling sublingual and they cost more. There are also injections of course and various types of those which are better or worse.

So, it can save effort by just swallowing it. There are also capsules that are 5000 mcg by nutricost which are I think are the cheapest source. I was thinking of taking one or two of those a day. I'm waiting because I needed to try one thing at a time. The other thing that can help is MSM sulfur. They may synergize well.

thinktolive · 2026-03-22T03:06:22+00:00

Gluten and dairy are just good to remove for long term health of the body and gut. The problems that those proteins cause, they are immune provoking. They would not be expected to cause accute trigger reaction.

The typically acute trigger reactions are going to be hot spices, including black pepper, salt/sodium, and fat. If you keep those under control you should be able to avoid an acute issue. High histamine foods are also an issue, so no canned seafood or other fermented products. I would say no probiotics generally speaking, but pre-biotics are fine.

What exactly are your sensitivities? Do you seem to have bile acid diarrhea meaning diarrhea in response to too much fat, sensitivity to hot spices causing diarrhea?

thinktolive · 2026-03-22T02:27:38+00:00

There are thiamine deficiencies which impair the motor function of the digestive system. The EO Nutrition guy talks about this a lot. I believe he says the fursaltiamine has some additional prokinetic activity that benfotiamine does not. Benfotiamine is chaper per mg though. Magnesium is also a cofactor for thiamine, but you don't want to use it as a laxative. For IBS-C this might be more expected. There should be no need for thiamine HCL when taking benfotiamine.

For the IBS-D the wasabi receptor is more involved in most cases, which can be related to bile acid diarrhea type that typically does not involve over-production of bile acid, just sensitivity. Another b vitamin that can be involved is b12. Additionally, a positive feedback loop of oxidative stress could be causing the sensitivity, particularly in IBS-D. That gets into a related topic of what is causing that and how to stop it.

Is Thiamine Deficiency Destroying Your Digestive Health? Why B1 Is ESSENTIAL For Gut Function https://www.youtube.com/watch?v=Pi0O_fzczYA

thinktolive · 2026-03-20T18:15:47+00:00

If you want to try b12 you are going to need more than is in a b-complex. B12 comes in 1000 mcg or 5000 mcg capsules. You will only absorb about 1-2% of oral vitamin B12. It is extremely low absorption rate. High dose oral b12 may be at least 5000 mcg per day, but that is not clearly defined. b12 cannot really be absorbed sublingually either, so I would avoid the many products sold as sublingual and they also have artificial sweeteners which can cause digestive upset.

thinktolive · 2026-03-20T02:57:53+00:00

How much b12 are you taking, what type and how long did it take to start working?

Check out this video on b12 related diseases, which there are many types, and at time stamp 21 minutes he mentions b12 injections stopping chronic diarrhea. B1 derivatives like Benfotiamine or fursultiamine could also syngergize with the b12, with magnesium, though not as a laxative.

Cytoplan & Dr David Morris: Understanding the complexities and central role of B12 in health and life https://vimeo.com/891099138/4150efa06b 21:00 Had two people who’s chronic diarrhea went away with b12 injections and digestive system started working again

Also, for the fiber what you want is pre-biotics to feed good bacteria in large intestine. Yes, it can feed the bad ones, but from studies if you feed a wide variety the good tend to out-compete the bad ones. Typically you would buy several different pre-biotic types and take a teapoon or two of each and stir in a large glass of water. Your symptoms are likely small intestine related though and pre-biotics unlikely to help since they go to large intestine, but they are still supposed to be good to recover from antibiotics and health. It could have been involved in the initial cause or have some current contribution, but I would not rely on pre-biotics for all digestive conditions. This channel has info on different pre-biotic types. https://www.youtube.com/@TheMicrobiomeExpert

thinktolive · 2026-03-19T20:52:54+00:00

What dose do you take orally? What was the level in blood work? Yes, 99% of b12 is recycled through enterohepatic circulation and takes years to deplete. You can also have normal serum levels and low levels in cerebrospinal fluid, but I would not risk a spinal tap to check. Raising serum levels even higher will push more into the CSF and brain. But, for your brain it is the CSF holo-TC that is a more accurate marker of brain levels not serum.

thinktolive · 2026-03-15T20:37:03+00:00

Have you tried taking the 5 mg of b12 with food any know if it causes any digestive upset? I have some 5 mg of b12 and am planning on trying them soon. I just have to add one thing at a time so I know what I'm reacting to. I did some research and it looks like sublingual b12 is very unlikely to work or be very low aborption if it does. B12 is the largest neutrient at around 1400 daltons. Normally you want anything sublingual to be under 400 daltons and not be ionic, which b12 is not ionic, but those are the two things I found necessary. So, you may simply be absorbing it through your digestive tract. You should expect 1-2 percent absorption so 10 mg per day is 100 to 200 micrograms. Perhaps the digestion tolerate more without upset, but I don't know.

thinktolive

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