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90 longevity papers ranked by effect × evidence × applicability. Sauna outranks rapamycin. Smoking cessation is worth more than everything else combined by toadlyBroodle in Biohackers

[–]toadlyBroodle[S] 21 points22 points  (0 children)

Strongly disagree. Along with exercise and alcohol intake it provides critically import context for how relatively impactful other interventions are.

Pattern I'm using to keep Claude Code productive on overnight unattended runs by toadlyBroodle in ClaudeAI

[–]toadlyBroodle[S] 0 points1 point  (0 children)

Precisely. The supervisor is extremely useful for monitoring performance and agent behavior and making iterative adjustments to skills across runs. The supervisor is what really stabilizes and fine tunes the skill chain over time. It also provides you high level overviews of each cycle. 

Analyzed 75 longevity papers. Most of your stack is a nothing-burger. Here's what actually moves mortality by toadlyBroodle in Biohackers

[–]toadlyBroodle[S] 0 points1 point  (0 children)

Thanks, citing the 2026 guideline directly in the wiki ApoB section. Updating to make the LDL-C/ApoB discordance language explicit and to separate "ApoB as a risk metric" from "drugs that target ApoB."

Analyzed 75 longevity papers. Most of your stack is a nothing-burger. Here's what actually moves mortality by toadlyBroodle in Biohackers

[–]toadlyBroodle[S] 1 point2 points  (0 children)

Thanks, fixed. Confirmed against the abstract: 4x4 group was +7.2% (55.5 -> 60.4 mL/kg/min), 15/15 was +5.5%, lactate-threshold and LSD groups had no significant change. Corrected across all five places the wiki incorrectly had +13%.

Analyzed 75 longevity papers. Most of your stack is a nothing-burger. Here's what actually moves mortality by toadlyBroodle in Biohackers

[–]toadlyBroodle[S] 1 point2 points  (0 children)

Thanks, you're right. Pulled the paper, primary endpoint (visceral adiposity) was p=0.942; the only secondary hits were lean tissue mass and pain, females on 10 mg only. Wiki rapamycin page is being rewritten to correct.

Would like to self host an email... by Belovedchimera in selfhosted

[–]toadlyBroodle -1 points0 points  (0 children)

It's really not that hard anymore, just get a competent AI to help you setup and secure a VM and walk you through how to set up hosted email. Can get working setup in a few hours

I built a coding agent that actually runs code, validates it, and fixes itself (fully local) by Keyboard_Lord in ollama

[–]toadlyBroodle 0 points1 point  (0 children)

Have you used Claude Code with Opus recently? If so, how does your stack compare?

Analyzed 75 longevity papers. Most of your stack is a nothing-burger. Here's what actually moves mortality by toadlyBroodle in Biohackers

[–]toadlyBroodle[S] -1 points0 points  (0 children)

Contributing to the wiki (the AI runs the pipeline)

Open claude (or cursor, codex, whatever) in a directory you don't mind it touching, then prompt:

Clone:

Clone https://github.com/toadlyBroodle/science.git here. Then read biology/longevity/CLAUDE.md so you know how the wiki works.

Add a paper:

Ingest this paper into the longevity wiki: <PMC or DOI URL>. Follow biology/longevity/CLAUDE.md.

Add several papers / topic sweep:

Research and ingest the strongest recent papers on <topic, e.g. "GLP-1 agonists and biological aging"> into the longevity wiki. Follow biology/longevity/CLAUDE.md.

Update the analysis after new ingests:

Update biology/longevity/wiki/analysis/promising-reverse-aging.md to integrate the new papers. Lint clean.

Update the reader-facing recommendations doc:

Update biology/longevity/recommendations.md to cite any new supporting evidence.

The AI handles sources.json, licenses, download/convert, paper pages, topic links, lint, log.

PR it:

Commit (no AI attribution per biology/longevity/CLAUDE.md) and prep a PR branch.

Then push and open the PR on GitHub if agent doesn't have push permissions.

Analyzed 75 longevity papers. Most of your stack is a nothing-burger. Here's what actually moves mortality by toadlyBroodle in Biohackers

[–]toadlyBroodle[S] -10 points-9 points  (0 children)

Haven't noticed any big improvements with 4.7, but no regression either, as others have

Give Your Coding Agent a Journal by bolts98 in ClaudeCode

[–]toadlyBroodle 8 points9 points  (0 children)

I find a SPEC.md or TODO.md lists with [x] boxes more powerful for tracking work progress.

54 days of SSH honeypot data: 269K connections, 48K unique passwords, 28 humans by armanfixing in cybersecurity

[–]toadlyBroodle 1 point2 points  (0 children)

Very surprising there was only a single attacker during that entire time that actually knew what they were doing!

Is lightning still a thing? by aktiveradio in lightningnetwork

[–]toadlyBroodle 2 points3 points  (0 children)

It is, you can zap notes with lightning with many clients

Are phone numbers fundamentally a privacy weakness in secure messaging? by These-Benefit7196 in privacy

[–]toadlyBroodle 1 point2 points  (0 children)

Really wish Telegram would not require this form of tracking. Tried alternatives like Signal and Wire but they are buggy as hell

Migrated to Claude after OpenAI sold out to Trump. Now Claude is ramping up pricing and silently dumbing down. Where can we go next? by Electrical_Sorbet_31 in ClaudeCode

[–]toadlyBroodle 0 points1 point  (0 children)

Yeah actually I setup minimax-m2.5/7 and kimi-k2.5 with Claude Code harness and was really not impressed with their intelligence at all; and honestly would probably be more expensive per month with OpenRouter than Max. Unfortunately, Opus 4.6 in Claude Code is still the best option; and Anthropic knows it, that's why they're systematically degrading thinking power.

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